Ernst S Kooreman1, Petra J van Houdt1, Rick Keesman1, Floris J Pos1, Vivian W J van Pelt1, Marlies E Nowee1, Andreas Wetscherek2, Rob H N Tijssen3, Marielle E P Philippens3, Daniela Thorwarth4, Jihong Wang5, Amita Shukla-Dave6, William A Hall7, Eric S Paulson7, Uulke A van der Heide8. 1. Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. 2. Joint Department of Physics, The Institute of Cancer Research, and The Royal Marsden NHS Foundation Trust, London, United Kingdom. 3. Department of Radiotherapy, University Medical Center Utrecht, The Netherlands. 4. Section for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Germany. 5. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, United States. 6. Departments of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, United States. 7. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, United States. 8. Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: u.vd.heide@nki.nl.
Abstract
BACKGROUND AND PURPOSE: Diffusion-weighted imaging (DWI) for treatment response monitoring is feasible on hybrid magnetic resonance linear accelerator (MR-linac) systems. The MRI scanner of the Elekta Unity system has an adjusted design compared to diagnostic scanners. We investigated its impact on measuring the DWI-derived apparent diffusion coefficient (ADC) regarding three aspects: the choice of b-values, the spatial variation of the ADC, and scanning during radiation treatment. The aim of this study is to give recommendations for accurate ADC measurements on Unity systems. MATERIALS AND METHODS: Signal-to-noise ratio (SNR) measurements with increasing b-values were done to determine the highest bvalue that can be measured reliably. The spatial variation of the ADC was assessed on six Unity systems with a cylindrical phantom of 40 cm diameter. The influence of gantry rotation and irradiation was investigated by acquiring DWI images before and during treatment of 11 prostate cancer patients. RESULTS: On the Unity system, a maximum b-value of 500 s/mm2 should be used for ADC quantification, as a trade-off between SNR and diffusion weighting. Accurate ADC values were obtained within 7 cm from the iso-center, while outside this region ADC values deviated more than 5%. The ADC was not influenced by the rotating linac or irradiation during treatment. CONCLUSION: We provide Unity system specific recommendations for measuring the ADC. This will increase the consistency of ADC values acquired in different centers on the Unity system, enabling large cohort studies for biomarker discovery and treatment response monitoring.
BACKGROUND AND PURPOSE: Diffusion-weighted imaging (DWI) for treatment response monitoring is feasible on hybrid magnetic resonance linear accelerator (MR-linac) systems. The MRI scanner of the Elekta Unity system has an adjusted design compared to diagnostic scanners. We investigated its impact on measuring the DWI-derived apparent diffusion coefficient (ADC) regarding three aspects: the choice of b-values, the spatial variation of the ADC, and scanning during radiation treatment. The aim of this study is to give recommendations for accurate ADC measurements on Unity systems. MATERIALS AND METHODS: Signal-to-noise ratio (SNR) measurements with increasing b-values were done to determine the highest bvalue that can be measured reliably. The spatial variation of the ADC was assessed on six Unity systems with a cylindrical phantom of 40 cm diameter. The influence of gantry rotation and irradiation was investigated by acquiring DWI images before and during treatment of 11 prostate cancerpatients. RESULTS: On the Unity system, a maximum b-value of 500 s/mm2 should be used for ADC quantification, as a trade-off between SNR and diffusion weighting. Accurate ADC values were obtained within 7 cm from the iso-center, while outside this region ADC values deviated more than 5%. The ADC was not influenced by the rotating linac or irradiation during treatment. CONCLUSION: We provide Unity system specific recommendations for measuring the ADC. This will increase the consistency of ADC values acquired in different centers on the Unity system, enabling large cohort studies for biomarker discovery and treatment response monitoring.
Authors: Ernst S Kooreman; Petra J van Houdt; Marlies E Nowee; Vivian W J van Pelt; Rob H N Tijssen; Eric S Paulson; Oliver J Gurney-Champion; Jihong Wang; Folkert Koetsveld; Laurens D van Buuren; Leon C Ter Beek; Uulke A van der Heide Journal: Radiother Oncol Date: 2019-01-28 Impact factor: 6.280
Authors: Rob H N Tijssen; Marielle E P Philippens; Eric S Paulson; Markus Glitzner; Brige Chugh; Andreas Wetscherek; Michael Dubec; Jihong Wang; Uulke A van der Heide Journal: Radiother Oncol Date: 2018-12-31 Impact factor: 6.280
Authors: Stan J Hoogcarspel; Stefan E Zijlema; Rob H N Tijssen; Linda G W Kerkmeijer; Ina M Jürgenliemk-Schulz; Jan J W Lagendijk; Bas W Raaymakers Journal: Phys Med Biol Date: 2018-01-11 Impact factor: 3.609
Authors: James P B O'Connor; Eric O Aboagye; Judith E Adams; Hugo J W L Aerts; Sally F Barrington; Ambros J Beer; Ronald Boellaard; Sarah E Bohndiek; Michael Brady; Gina Brown; David L Buckley; Thomas L Chenevert; Laurence P Clarke; Sandra Collette; Gary J Cook; Nandita M deSouza; John C Dickson; Caroline Dive; Jeffrey L Evelhoch; Corinne Faivre-Finn; Ferdia A Gallagher; Fiona J Gilbert; Robert J Gillies; Vicky Goh; John R Griffiths; Ashley M Groves; Steve Halligan; Adrian L Harris; David J Hawkes; Otto S Hoekstra; Erich P Huang; Brian F Hutton; Edward F Jackson; Gordon C Jayson; Andrew Jones; Dow-Mu Koh; Denis Lacombe; Philippe Lambin; Nathalie Lassau; Martin O Leach; Ting-Yim Lee; Edward L Leen; Jason S Lewis; Yan Liu; Mark F Lythgoe; Prakash Manoharan; Ross J Maxwell; Kenneth A Miles; Bruno Morgan; Steve Morris; Tony Ng; Anwar R Padhani; Geoff J M Parker; Mike Partridge; Arvind P Pathak; Andrew C Peet; Shonit Punwani; Andrew R Reynolds; Simon P Robinson; Lalitha K Shankar; Ricky A Sharma; Dmitry Soloviev; Sigrid Stroobants; Daniel C Sullivan; Stuart A Taylor; Paul S Tofts; Gillian M Tozer; Marcel van Herk; Simon Walker-Samuel; James Wason; Kaye J Williams; Paul Workman; Thomas E Yankeelov; Kevin M Brindle; Lisa M McShane; Alan Jackson; John C Waterton Journal: Nat Rev Clin Oncol Date: 2016-10-11 Impact factor: 66.675
Authors: Amita Shukla-Dave; Nancy A Obuchowski; Thomas L Chenevert; Sachin Jambawalikar; Lawrence H Schwartz; Dariya Malyarenko; Wei Huang; Susan M Noworolski; Robert J Young; Mark S Shiroishi; Harrison Kim; Catherine Coolens; Hendrik Laue; Caroline Chung; Mark Rosen; Michael Boss; Edward F Jackson Journal: J Magn Reson Imaging Date: 2018-11-19 Impact factor: 5.119
Authors: Ulrik Ringborg; Anton Berns; Julio E Celis; Manuel Heitor; Josep Tabernero; Joachim Schüz; Michael Baumann; Rui Henrique; Matti Aapro; Partha Basu; Regina Beets-Tan; Benjamin Besse; Fátima Cardoso; Fátima Carneiro; Guy van den Eede; Alexander Eggermont; Stefan Fröhling; Susan Galbraith; Elena Garralda; Douglas Hanahan; Thomas Hofmarcher; Bengt Jönsson; Olli Kallioniemi; Miklós Kásler; Eva Kondorosi; Jan Korbel; Denis Lacombe; José Carlos Machado; José M Martin-Moreno; Francoise Meunier; Péter Nagy; Paolo Nuciforo; Simon Oberst; Júlio Oliveiera; Maria Papatriantafyllou; Walter Ricciardi; Alexander Roediger; Bettina Ryll; Richard Schilsky; Grazia Scocca; Raquel Seruca; Marta Soares; Karen Steindorf; Vincenzo Valentini; Emile Voest; Elisabete Weiderpass; Nils Wilking; Amanda Wren; Laurence Zitvogel Journal: Mol Oncol Date: 2021-09-13 Impact factor: 6.603
Authors: Travis C Salzillo; Nicolette Taku; Kareem A Wahid; Brigid A McDonald; Jarey Wang; Lisanne V van Dijk; Jillian M Rigert; Abdallah S R Mohamed; Jihong Wang; Stephen Y Lai; Clifton D Fuller Journal: Semin Radiat Oncol Date: 2021-10 Impact factor: 5.421
Authors: Ernst S Kooreman; Vivian van Pelt; Marlies E Nowee; Floris Pos; Uulke A van der Heide; Petra J van Houdt Journal: Front Oncol Date: 2022-06-07 Impact factor: 5.738
Authors: Paul J Keall; Caterina Brighi; Carri Glide-Hurst; Gary Liney; Paul Z Y Liu; Suzanne Lydiard; Chiara Paganelli; Trang Pham; Shanshan Shan; Alison C Tree; Uulke A van der Heide; David E J Waddington; Brendan Whelan Journal: Nat Rev Clin Oncol Date: 2022-04-19 Impact factor: 65.011
Authors: Adham Hijab; Boris Tocco; Ian Hanson; Hanneke Meijer; Christina Junker Nyborg; Anders Smedegaard Bertelsen; Robert Jan Smeenk; Gillian Smith; Jeff Michalski; Brian C Baumann; Shaista Hafeez Journal: Front Oncol Date: 2021-02-25 Impact factor: 6.244
Authors: Catherine Coolens; Matt N Gwilliam; Paula Alcaide-Leon; Isabella Maria de Freitas Faria; Fabio Ynoe de Moraes Journal: Cancers (Basel) Date: 2021-05-23 Impact factor: 6.639
Authors: Petra J van Houdt; Hina Saeed; Daniela Thorwarth; Clifton D Fuller; William A Hall; Brigid A McDonald; Amita Shukla-Dave; Ernst S Kooreman; Marielle E P Philippens; Astrid L H M W van Lier; Rick Keesman; Faisal Mahmood; Catherine Coolens; Teodor Stanescu; Jihong Wang; Neelam Tyagi; Andreas Wetscherek; Uulke A van der Heide Journal: Eur J Cancer Date: 2021-06-15 Impact factor: 10.002
Authors: Enrica Seravalli; Petra S Kroon; John M Buatti; Matthew D Hall; Henry C Mandeville; Karen J Marcus; Cem Onal; Enis Ozyar; Arnold C Paulino; Frank Paulsen; Daniel Saunders; Derek S Tsang; Suzanne L Wolden; Geert O Janssens Journal: Clin Transl Radiat Oncol Date: 2021-06-04