Wei Xian1,2,3,4, Jiayi Shen4, Huaqiang Zhou1,2,3, Jiaqing Liu1,2,3, Yaxiong Zhang1,2,3, Zhonghan Zhang1,2,3, Ting Zhou1,2,3, Shaodong Hong1,2,3, Yunpeng Yang1,2,3, Wenfeng Fang1,2,3, Hongyun Zhao1,2,3, Yan Huang1,2,3, Li Zhang5,6,7. 1. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China. 2. State Key Laboratory of Oncology in South China, Guangzhou, 510060, China. 3. Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China. 4. Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. 5. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China. zhangli6@mail.sysu.edu.cn. 6. State Key Laboratory of Oncology in South China, Guangzhou, 510060, China. zhangli6@mail.sysu.edu.cn. 7. Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China. zhangli6@mail.sysu.edu.cn.
Abstract
BACKGROUND: Previous researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer. METHODS: We analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two-sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancer patients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer. RESULTS: According to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88-1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method. CONCLUSION: Our mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer.
BACKGROUND: Previous researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer. METHODS: We analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two-sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancerpatients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer. RESULTS: According to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88-1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method. CONCLUSION: Our mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer.
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