Literature DB >> 32977059

Fight to the bitter end: DNA repair and aging.

Yu Chen1, Anke Geng1, Weina Zhang1, Zhen Qian1, Xiaoping Wan1, Ying Jiang1, Zhiyong Mao2.   

Abstract

DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.
Copyright © 2020 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aging; DNA repair; DNA repair reporter cassette; Inflammation; Rejuvenation; Senescence

Mesh：

Year:  2020        PMID： 32977059     DOI： 10.1016/j.arr.2020.101154

Source DB:  PubMed          Journal:  Ageing Res Rev        ISSN： 1568-1637            Impact factor:   10.895


  7 in total

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Authors:  Hao Wang; Amit K Saha; Xuming Sun; Neal D Kon; Carlos M Ferrario; Leanne Groban
Journal:  Curr Opin Anaesthesiol       Date:  2021-04-01       Impact factor: 2.706

2.  DNA repair in cancer development and aging.

Authors:  Hua Zhao; Bernard F Fuemmeler; Jie Shen
Journal:  Aging (Albany NY)       Date:  2021-10-26       Impact factor: 5.682

3.  BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates.

Authors:  Chuqian Liang; Qiong Ke; Zunpeng Liu; Jie Ren; Weiqi Zhang; Jianli Hu; Zehua Wang; Hong Chen; Kai Xia; Xingqiang Lai; Qiaoran Wang; Kuan Yang; Wei Li; Zeming Wu; Chao Wang; Haoteng Yan; Xiaoyu Jiang; Zhejun Ji; Miyang Ma; Xiao Long; Si Wang; Huating Wang; Hao Sun; Juan Carlos Izpisua Belmonte; Jing Qu; Andy Peng Xiang; Guang-Hui Liu
Journal:  Nucleic Acids Res       Date:  2022-04-08       Impact factor: 16.971

Review 4.  The landscape of aging.

Authors:  Yusheng Cai; Wei Song; Jiaming Li; Ying Jing; Chuqian Liang; Liyuan Zhang; Xia Zhang; Wenhui Zhang; Beibei Liu; Yongpan An; Jingyi Li; Baixue Tang; Siyu Pei; Xueying Wu; Yuxuan Liu; Cheng-Le Zhuang; Yilin Ying; Xuefeng Dou; Yu Chen; Fu-Hui Xiao; Dingfeng Li; Ruici Yang; Ya Zhao; Yang Wang; Lihui Wang; Yujing Li; Shuai Ma; Si Wang; Xiaoyuan Song; Jie Ren; Liang Zhang; Jun Wang; Weiqi Zhang; Zhengwei Xie; Jing Qu; Jianwei Wang; Yichuan Xiao; Ye Tian; Gelin Wang; Ping Hu; Jing Ye; Yu Sun; Zhiyong Mao; Qing-Peng Kong; Qiang Liu; Weiguo Zou; Xiao-Li Tian; Zhi-Xiong Xiao; Yong Liu; Jun-Ping Liu; Moshi Song; Jing-Dong J Han; Guang-Hui Liu
Journal:  Sci China Life Sci       Date:  2022-09-02       Impact factor: 10.372

5.  Blood transcriptome analysis revealing aging gene expression profiles in red panda.

Authors:  Jing Luo; Liang Zhang; Fujun Shen; Li Luo; Lei Chen; Zhenxin Fan; Rong Hou; Bisong Yue; Xiuyue Zhang
Journal:  PeerJ       Date:  2022-07-22       Impact factor: 3.061

6.  Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis.

Authors:  Michaela E Copp; Susan Chubinskaya; Daniel N Bracey; Jacqueline Shine; Garrett Sessions; Richard F Loeser; Brian O Diekman
Journal:  Aging Cell       Date:  2022-08-22       Impact factor: 11.005

Review 7.  Aging conundrum: A perspective for ovarian aging.

Authors:  Jiachen Wu; Yang Liu; Yinhua Song; Lingjuan Wang; Jihui Ai; Kezhen Li
Journal:  Front Endocrinol (Lausanne)       Date:  2022-08-19       Impact factor: 6.055
  7 in total

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