| Literature DB >> 36066811 |
Yusheng Cai1,2,3, Wei Song4, Jiaming Li5,6, Ying Jing6,7, Chuqian Liang1,2,3, Liyuan Zhang5, Xia Zhang8, Wenhui Zhang6,9, Beibei Liu5, Yongpan An10, Jingyi Li1,2,3, Baixue Tang11, Siyu Pei8, Xueying Wu12, Yuxuan Liu13, Cheng-Le Zhuang14, Yilin Ying15,16, Xuefeng Dou8, Yu Chen17, Fu-Hui Xiao18,19, Dingfeng Li20, Ruici Yang21, Ya Zhao22, Yang Wang23, Lihui Wang24, Yujing Li1,2,3, Shuai Ma25,26,27, Si Wang28,29,30, Xiaoyuan Song31, Jie Ren32,33,34, Liang Zhang35,36, Jun Wang37,38, Weiqi Zhang39,40,41,42, Zhengwei Xie43, Jing Qu44,45,46, Jianwei Wang47, Yichuan Xiao48, Ye Tian49,50, Gelin Wang51, Ping Hu52,53,54, Jing Ye55,56, Yu Sun57,58, Zhiyong Mao59, Qing-Peng Kong60,61, Qiang Liu62,63, Weiguo Zou64, Xiao-Li Tian65, Zhi-Xiong Xiao66, Yong Liu67, Jun-Ping Liu68,69,70, Moshi Song71,72,73,74, Jing-Dong J Han75, Guang-Hui Liu76,77,78,79,80,81.
Abstract
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on "healthy aging" raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.Entities:
Keywords: aging; intervention; mechanism
Year: 2022 PMID： 36066811 PMCID： PMC9446657 DOI： 10.1007/s11427-022-2161-3
Source DB: PubMed Journal: Sci China Life Sci ISSN： 1674-7305 Impact factor: 10.372