| Literature DB >> 32969551 |
Tom A R Price1, Nikolai Windbichler2, Robert L Unckless3, Andreas Sutter4, Jan-Niklas Runge5, Perran A Ross6, Andrew Pomiankowski7, Nicole L Nuckolls8, Catherine Montchamp-Moreau9, Nicole Mideo10, Oliver Y Martin11, Andri Manser1, Mathieu Legros12,13, Amanda M Larracuente14, Luke Holman15, John Godwin16, Neil Gemmell17, Cécile Courret9,13, Anna Buchman18,19, Luke G Barrett12, Anna K Lindholm5.
Abstract
Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.Entities:
Keywords: zzm321990Wolbachiazzm321990; CRISPR-Cas9; fitness costs; meiotic drive; population suppression; selfish genetic elements; sex ratio distorter; transposable element
Mesh：
Year: 2020 PMID： 32969551 PMCID： PMC7796552 DOI： 10.1111/jeb.13693
Source DB: PubMed Journal: J Evol Biol ISSN： 1010-061X Impact factor: 2.411