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Literature DB >> 3294857

Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum.

Abstract

The distribution of acetylated alpha-tubulin in rat cerebellum was examined and compared with that of total alpha-tubulin and tyrosinated alpha-tubulin. From immunoperoxidase-stained vibratome sections of rat cerebellum it was found that acetylated alpha-tubulin, detectable with monoclonal 6-11B-1, was preferentially enriched in axons compared with dendrites. Parallel fiber axons, in particular, were labeled with 6-11B-1 yet unstained by an antibody recognizing tyrosinated alpha-tubulin, indicating that parallel fibers contain alpha-tubulin that is acetylated and detyrosinated. Axonal microtubules are known to be highly stable and the distribution of acetylated alpha-tubulin in other classes of stable microtubules suggests that acetylation and possibly detyrosination may play a role in the maintenance of stable populations of microtubules.

Entities: Chemical Species

Mesh：

Substances：
Tubulin
Tyrosine

Year: 1987 PMID： 3294857 PMCID： PMC2114518 DOI： 10.1083/jcb.104.6.1569

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

33 in total

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Authors: K M Yamada; B S Spooner; N K Wessells
Journal: Proc Natl Acad Sci U S A Date: 1970-08 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 1970-05 Impact factor: 11.205

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Journal: J Biol Chem Date: 1981-07-25 Impact factor: 5.157

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Journal: Eur J Cell Biol Date: 1983-09 Impact factor: 4.492

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Authors: W C Thompson
Journal: Methods Cell Biol Date: 1982 Impact factor: 1.441

6. An improved method for the bulk isolation of viable perikarya from postnatal cerebellum.

Authors: G R Dutton; D N Currie; K Tear
Journal: J Neurosci Methods Date: 1981-04 Impact factor: 2.390

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Journal: Neurosci Lett Date: 1982-07-20 Impact factor: 3.046

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Journal: Experientia Date: 1979-03-15

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Authors: J V Kilmartin; B Wright; C Milstein
Journal: J Cell Biol Date: 1982-06 Impact factor: 10.539

10. Immunocytochemical localization of microtubule-associated protein 1 in rat cerebellum using monoclonal antibodies.

Authors: G Huber; A Matus
Journal: J Cell Biol Date: 1984-02 Impact factor: 10.539

47 in total

Review 1. Organization and slow axonal transport of cytoskeletal proteins under normal and regenerating conditions.

Authors: T Tashiro; Y Komiya
Journal: Mol Neurobiol Date: 1992 Summer-Fall Impact factor: 5.590

Review 2. Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions.

Authors: Carsten Janke; Jeannette Chloë Bulinski
Journal: Nat Rev Mol Cell Biol Date: 2011-11-16 Impact factor: 94.444

3. Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.

Authors: Haruka Sudo; Peter W Baas
Journal: Hum Mol Genet Date: 2010-11-30 Impact factor: 6.150

4. Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts.

Authors: Haruka Sudo; Peter W Baas
Journal: J Neurosci Date: 2010-05-26 Impact factor: 6.167

5. Tyrosinated, detyrosinated and acetylated tubulin isotypes in rat brain membranes. Their proportions in comparison with those in cytosol.

Authors: D M Beltramo; A C Alonso; H S Barra
Journal: Mol Cell Biochem Date: 1992-06-26 Impact factor: 3.396