Giannicola Iannella1,2, Giuseppe Magliulo3, Antonino Maniaci4, Giuseppe Meccariello5, Salvatore Cocuzza4, Giovanni Cammaroto5, Riccardo Gobbi5, Rossella Sgarzani6, Elisabetta Firinu5, Ruggero Massimo Corso7, Annalisa Pace3, Giampiero Gulotta3, Irene Claudia Visconti3, Milena Di Luca4, Stefano Pelucchi8, Giulia Bianchi8, Michela Melegatti8, Pietro Abita9, Carmen Solito3, Ignazio La Mantia4, Calogero Grillo4, Claudio Vicini3,8. 1. Otolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy. giannicola.iannella@uniroma1.it. 2. Department of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy. giannicola.iannella@uniroma1.it. 3. Department of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy. 4. ENT Section, Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 78, 95125, Catania, Italy. 5. Otolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy. 6. Department of Emergency, Burn Center, Bufalini Hospital, Azienda USL Della Romagna, viale Giovanni Ghirotti, 286, 47521, Cesena, Italy. 7. Intensive Care Unit, Morgagni-Pierantoni Hospital, AUSL of Romagna, Via Carlo Forlanini, 34, 47121, Forlì, Italy. 8. Department ENT and Audiology, University of Ferrara, Via Savonarola, 9, 44121, Ferrara, Italy. 9. Unit of Otorhinolaryngology, Department of Adult and Development Age Human Pathology "Gaetano Barresi", University of Messina, Messina, Italy.
Abstract
PURPOSE: This meta-analysis study was designed to analyze the olfactory function in obstructive sleep apnea patients (OSA). METHODS: A comprehensive review of the English language literature regarding OSA patients and olfactory function/dysfunction was performed. The papers assessing olfactory dysfunction with Sniffin' Sticks test were taken into consideration. RESULTS: A total of 420 OSA patients were judged eligible for the study. The average TDI score was found to be 24.3 ± 5.6. The olfactory identification (OD), the olfactory discrimination (OD), and the olfactory threshold (OT) average values were calculated resulting 9.9 ± 2.1, 9.8 ± 1.5, and 5.3 ± 2, respectively. There were 161 healthy control subjects in this meta-analysis. The average TDI of the control group was 30.7 ± 6.0 showing a statistical difference with the group of OSA patients (p = 0.03). A linear correlation between Apnea-Hypopnea Index (AHI) increase and TDI decrease (R2 = 0.1, p = 0.05) was detected. Finally, the average values of TDI of 151 patients classified as mild-moderate OSA and 159 patients considered as severe OSA were calculated. The difference between these two groups resulted not statistically significant (p = 0.3). CONCLUSION: The comparison between OSA patients and healthy subjects using Sniffin' Sticks test showed lower values of the various olfactory parameters. Although a linear correlation between AHI increase and olfactory dysfunction was observed, no statistical difference between mild-moderate and severe OSA patients in terms of the severity of olfactory dysfunction could be proved.
PURPOSE: This meta-analysis study was designed to analyze the olfactory function in obstructive sleep apneapatients (OSA). METHODS: A comprehensive review of the English language literature regarding OSA patients and olfactory function/dysfunction was performed. The papers assessing olfactory dysfunction with Sniffin' Sticks test were taken into consideration. RESULTS: A total of 420 OSA patients were judged eligible for the study. The average TDI score was found to be 24.3 ± 5.6. The olfactory identification (OD), the olfactory discrimination (OD), and the olfactory threshold (OT) average values were calculated resulting 9.9 ± 2.1, 9.8 ± 1.5, and 5.3 ± 2, respectively. There were 161 healthy control subjects in this meta-analysis. The average TDI of the control group was 30.7 ± 6.0 showing a statistical difference with the group of OSA patients (p = 0.03). A linear correlation between Apnea-Hypopnea Index (AHI) increase and TDI decrease (R2 = 0.1, p = 0.05) was detected. Finally, the average values of TDI of 151 patients classified as mild-moderate OSA and 159 patients considered as severe OSA were calculated. The difference between these two groups resulted not statistically significant (p = 0.3). CONCLUSION: The comparison between OSA patients and healthy subjects using Sniffin' Sticks test showed lower values of the various olfactory parameters. Although a linear correlation between AHI increase and olfactory dysfunction was observed, no statistical difference between mild-moderate and severe OSA patients in terms of the severity of olfactory dysfunction could be proved.
Authors: Süleyman Emre Karakurt; Mehmet Fatih Karakuş; Mustafa Çolak; Şeyda Akbal; Mehmet Ali Çetin; Aykut İkincioğulları; Hacı Hüseyin Dere Journal: Sleep Breath Date: 2019-12-16 Impact factor: 2.816
Authors: Giannicola Iannella; Antonino Maniaci; Giuseppe Magliulo; Salvatore Cocuzza; Ignazio La Mantia; Giovanni Cammaroto; Antonio Greco; Claudio Vicini Journal: Pol Arch Intern Med Date: 2020-04-06
Authors: G Magliulo; M De Vincentiis; G Iannella; A Ciofalo; B Pasquariello; A Manno; D Angeletti; A Polimeni Journal: Acta Otorhinolaryngol Ital Date: 2018-08 Impact factor: 2.124
Authors: Antonino Maniaci; Milena Di Luca; Jerome René Lechien; Giannicola Iannella; Calogero Grillo; Caterina Maria Grillo; Federico Merlino; Christian Calvo-Henriquez; Andrea De Vito; Giuseppe Magliulo; Annalisa Pace; Claudio Vicini; Salvatore Cocuzza; Vittoria Bannò; Isabella Pollicina; Giovanna Stilo; Alberto Bianchi; Ignazio La Mantia Journal: Sleep Breath Date: 2022-01-03 Impact factor: 2.816
Authors: Eddie W Fakhouri; Jeremy A Weingarten; Shailendra P Singh; Purvi Shah; Stephen J Peterson Journal: Oxid Med Cell Longev Date: 2021-11-24 Impact factor: 6.543
Authors: Giannicola Iannella; Giuseppe Magliulo; Antonio Greco; Marco de Vincentiis; Massimo Ralli; Antonino Maniaci; Annalisa Pace; Claudio Vicini Journal: Int J Environ Res Public Health Date: 2022-02-21 Impact factor: 3.390