Antonino Maniaci1,2, Salvatore Ferlito3, Jerome Rene Lechien4,5, Milena Di Luca3, Giannicola Iannella6, Giovanni Cammaroto4,7, Angelo Cannavicci7, Isabella Pollicina3, Giovanna Stilo3, Paola Di Mauro3, Giuseppe Magliulo6, Annalisa Pace6, Claudio Vicini7. 1. Department of Medical, Surgical and Advanced Technologies G.F. Ingrassia, ENT Section, University of Catania, Via Santa Sofia, 95100, Catania, Italy. tnmaniaci29@gmail.com. 2. Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France. tnmaniaci29@gmail.com. 3. Department of Medical, Surgical and Advanced Technologies G.F. Ingrassia, ENT Section, University of Catania, Via Santa Sofia, 95100, Catania, Italy. 4. Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France. 5. Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. 6. Department of Sensory Organs, "Sapienza" University of Rome, 00100, Rome, Italy. 7. Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, 47121, Forli, Italy.
Abstract
PURPOSE: To evaluate the efficacy of barbed reposition pharyngoplasty (BRP) on sleepiness, anxiety, and depression o adult patients with obstructive sleep apnea (OSA). METHODS: We performed a prospective multicentric study to assess functional outcomes in 20 OSA patients treated with BRP and compare the results with an observational group of 20 subjects. All recruited subjects performed at baseline and 6-months postoperative follow-up Polysomnography (PSG), daytime sleepiness scoring using the Epworth Sleepiness Scale (ESS), and anxiety and depression evaluation via the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory-II (BDI-II) questionnaires. RESULTS: At follow-up the BRP demonstrated greater improvements in AHI (8.92 ± 2.29 vs. 30.66 ± 2.56; p < 0.001) and ODI (7.65 ± 2.39 vs. 24.55 ± 3.20; p < 0.001) than control at intergroup analysis. Surgical group reported significant data in daytime sleepiness (5.15 ± 1.19 vs. 13.15 ± 1.35; p < 0.001), anxiety (12.65 ± 3.11 vs. 24.2 ± 2.37; p < 0.001), and depression domains (5.85 ± 1.19 vs. 17.55 ± 3.24; p < 0.001). AHI, ODI, and advanced age have been shown to multiple regression as independent predictors of treatment response for mood domains (p < 0.001; p = 0.02; p = 0.041, respectively). CONCLUSIONS: Patients with OSA may benefit from palate surgery, reducing not only the apnea and hypopnea index, daytime sleepiness but also associated mood comorbidities. However, further studies are needed to confirm our preliminary results to validate the evidence to date reported.
PURPOSE: To evaluate the efficacy of barbed reposition pharyngoplasty (BRP) on sleepiness, anxiety, and depression o adult patients with obstructive sleep apnea (OSA). METHODS: We performed a prospective multicentric study to assess functional outcomes in 20 OSA patients treated with BRP and compare the results with an observational group of 20 subjects. All recruited subjects performed at baseline and 6-months postoperative follow-up Polysomnography (PSG), daytime sleepiness scoring using the Epworth Sleepiness Scale (ESS), and anxiety and depression evaluation via the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory-II (BDI-II) questionnaires. RESULTS: At follow-up the BRP demonstrated greater improvements in AHI (8.92 ± 2.29 vs. 30.66 ± 2.56; p < 0.001) and ODI (7.65 ± 2.39 vs. 24.55 ± 3.20; p < 0.001) than control at intergroup analysis. Surgical group reported significant data in daytime sleepiness (5.15 ± 1.19 vs. 13.15 ± 1.35; p < 0.001), anxiety (12.65 ± 3.11 vs. 24.2 ± 2.37; p < 0.001), and depression domains (5.85 ± 1.19 vs. 17.55 ± 3.24; p < 0.001). AHI, ODI, and advanced age have been shown to multiple regression as independent predictors of treatment response for mood domains (p < 0.001; p = 0.02; p = 0.041, respectively). CONCLUSIONS: Patients with OSA may benefit from palate surgery, reducing not only the apnea and hypopnea index, daytime sleepiness but also associated mood comorbidities. However, further studies are needed to confirm our preliminary results to validate the evidence to date reported.
Authors: Giannicola Iannella; Claudio Vicini; Andrea Colizza; Giuseppe Meccariello; Antonella Polimeni; Antonio Greco; Marco de Vincentiis; Andrea de Vito; Giovanni Cammaroto; Riccardo Gobbi; Chiara Bellini; Elisabetta Firinu; Stefano Pelucchi; Giampiero Gulotta; Irene Claudia Visconti; Milena di Luca; Giuseppe Magliulo Journal: Eur Arch Otorhinolaryngol Date: 2019-11-09 Impact factor: 2.503
Authors: Milada Hobzova; Jan Prasko; Jakub Vanek; Marie Ociskova; Samuel Genzor; Michaela Holubova; Ales Grambal; Klara Latalova Journal: Neuro Endocrinol Lett Date: 2017-10 Impact factor: 0.765
Authors: Claudio Vicini; Andrea De Vito; Giannicola Iannella; Riccardo Gobbi; Ruggero Massimo Corso; Filippo Montevecchi; Antonella Polimeni; Marco De Vincentiis; Giuseppe Meccariello; Giovanni D'agostino; Giovanni Cammaroto; Francesco Stomeo; Giuseppe Magliulo Journal: Eur Arch Otorhinolaryngol Date: 2018-10-13 Impact factor: 2.503
Authors: Giannicola Iannella; Antonino Maniaci; Giuseppe Magliulo; Salvatore Cocuzza; Ignazio La Mantia; Giovanni Cammaroto; Antonio Greco; Claudio Vicini Journal: Pol Arch Intern Med Date: 2020-04-06
Authors: Vishesh K Kapur; Dennis H Auckley; Susmita Chowdhuri; David C Kuhlmann; Reena Mehra; Kannan Ramar; Christopher G Harrod Journal: J Clin Sleep Med Date: 2017-03-15 Impact factor: 4.062