Literature DB >> 3290653

Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.

L E Diamond1, I Guerrero, A Pellicer.   

Abstract

We have surveyed a panel of induced murine lymphomas for c-ras gene mutations. The K-ras gene seems to be preferentially activated in our system, and there are at least two examples of concomitant K- and N-ras gene mutations in the same tumor. This indicates that in some cases additional ras mutations may contribute to tumorigenesis and is evidence for a role of ras activation in tumor progression.

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Year:  1988        PMID： 3290653      PMCID： PMC363408          DOI： 10.1128/mcb.8.5.2233-2236.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  20 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

Authors:  C I Bargmann; M C Hung; R A Weinberg
Journal:  Cell       Date:  1986-06-06       Impact factor: 41.582

3.  A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

Authors:  H Saito; D M Kranz; Y Takagaki; A C Hayday; H N Eisen; S Tonegawa
Journal:  Nature       Date:  1984 Nov 1-7       Impact factor: 49.962

4.  Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.

Authors:  S Sukumar; V Notario; D Martin-Zanca; M Barbacid
Journal:  Nature       Date:  1983 Dec 15-21       Impact factor: 49.962

5.  Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.

Authors:  J L Bos; D Toksoz; C J Marshall; M Verlaan-de Vries; G H Veeneman; A J van der Eb; J H van Boom; J W Janssen; A C Steenvoorden
Journal:  Nature       Date:  1985 Jun 27-Jul 3       Impact factor: 49.962

6.  A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.

Authors:  I Guerrero; P Calzada; A Mayer; A Pellicer
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

7.  Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.

Authors:  I Guerrero; A Villasante; V Corces; A Pellicer
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

8.  Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene.

Authors:  A Balmain; I B Pragnell
Journal:  Nature       Date:  1983 May 5-11       Impact factor: 49.962

9.  Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.

Authors:  H Zarbl; S Sukumar; A V Arthur; D Martin-Zanca; M Barbacid
Journal:  Nature       Date:  1985 May 30-Jun 5       Impact factor: 49.962

10.  alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene.

Authors:  V J Kidd; R B Wallace; K Itakura; S L Woo
Journal:  Nature       Date:  1983 Jul 21-27       Impact factor: 49.962
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  16 in total

1.  Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.

Authors:  K Inokuchi; N Amuro; M Futaki; K Dan; T Shinohara; S Kuriya; T Okazaki; T Nomura
Journal:  Ann Hematol       Date:  1991-06       Impact factor: 3.673

2.  Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation.

Authors:  S R Sloan; E W Newcomb; A Pellicer
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

3.  Wild type N-ras displays anti-malignant properties, in part by downregulating decorin.

Authors:  Marta Benet; Robin Yates Dulman; Raffi Suzme; Eleazar Vega-Saenz de Miera; Martha E Vega; Thuy Nguyen; Jiri Zavadil; Angel Pellicer
Journal:  J Cell Physiol       Date:  2012-06       Impact factor: 6.384

4.  Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

Authors:  S E Andrew; M McKinnon; B S Cheng; A Francis; J Penney; A H Reitmair; T W Mak; F R Jirik
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-03       Impact factor: 11.205

5.  Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors.

Authors:  M Souyri; I Vigon; M Charon; P Tambourin
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

6.  Oncogene cooperation in lymphocyte transformation: malignant conversion of E mu-myc transgenic pre-B cells in vitro is enhanced by v-H-ras or v-raf but not v-abl.

Authors:  W S Alexander; J M Adams; S Cory
Journal:  Mol Cell Biol       Date:  1989-01       Impact factor: 4.272

7.  T-cell receptor gene rearrangement in primary tumors: effect of genetic background and inducing agent.

Authors:  L E Diamond; S R Sloan; A Pellicer; A C Hayday
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

8.  Analysis of RAS oncogene mutations in human lymphoid malignancies.

Authors:  A Neri; D M Knowles; A Greco; F McCormick; R Dalla-Favera
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

9.  Oncogene activation in human benign tumors of the skin (keratoacanthomas): is HRAS involved in differentiation as well as proliferation?

Authors:  M Corominas; H Kamino; J Leon; A Pellicer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

10.  Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice.

Authors:  E R Richie; J M Angel; M W Cloyd
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103
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