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Literature DB >> 6208487

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

H Saito, D M Kranz, Y Takagaki, A C Hayday, H N Eisen, S Tonegawa.

Abstract

In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the alpha-subunit of the heterodimeric antigen receptor of this T-cell clone.

Entities: Chemical Gene

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Year: 1984 PMID： 6208487 DOI： 10.1038/312036a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

137 in total

1. Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily.

Authors: R K Wilson; E Lai; L D Kim; L Hood
Journal: Immunogenetics Date: 1990 Impact factor: 2.846

2. Identification of a mouse T-cell antigen receptor alpha-chain polymorphism by a V alpha 3.2 chain-specific monoclonal antibody.

Authors: Y Utsunomiya; J Bill; E Palmer; O Kanagawa
Journal: Immunogenetics Date: 1991 Impact factor: 2.846

3. Evolving concepts of specificity in immune reactions.

Authors: Herman N Eisen; Arup K Chakraborty
Journal: Proc Natl Acad Sci U S A Date: 2010-12-20 Impact factor: 11.205

4. Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia. V gamma gene usage differs in mature and immature T cells.

Authors: J Hara; S H Benedict; K Yumura; K Ha-Kawa; E W Gelfand
Journal: J Clin Invest Date: 1989-04 Impact factor: 14.808

5. Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.

Authors: H Saito; T Koyama; K Georgopoulos; H Clevers; W G Haser; T LeBien; S Tonegawa; C Terhorst
Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205

10. A murine retrovirus induces proliferation of unique lymphoid cell lines expressing T-cell-receptor structures utilizing common variable region alpha and beta chain genes.

Authors: H C O'Neill
Journal: Proc Natl Acad Sci U S A Date: 1993-04-01 Impact factor: 11.205

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

1. Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily.

2. Identification of a mouse T-cell antigen receptor alpha-chain polymorphism by a V alpha 3.2 chain-specific monoclonal antibody.

3. Evolving concepts of specificity in immune reactions.

4. Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia. V gamma gene usage differs in mature and immature T cells.

5. Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.

6. Characterization of a single-chain T-cell receptor expressed in Escherichia coli.

7. Sequence and diversity of bovine T-cell receptor beta-chain genes.

8. T cell receptors and immunoregulation.

9. Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity.

10. A murine retrovirus induces proliferation of unique lymphoid cell lines expressing T-cell-receptor structures utilizing common variable region alpha and beta chain genes.