Literature DB >> 32895543

A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data.

Javier de la Fuente1,2, Gail Davies3,4, Andrew D Grotzinger1, Elliot M Tucker-Drob5,6, Ian J Deary7,8.   

Abstract

It has been known since 1904 that, in humans, diverse cognitive traits are positively intercorrelated. This forms the basis for the general factor of intelligence (g). Here, we directly test whether there is a partial genetic basis for individual differences in g using data from seven different cognitive tests (n = 11,263-331,679) and genome-wide autosomal single-nucleotide polymorphisms. A genetic g factor accounts for an average of 58.4% (s.e. = 4.8%) of the genetic variance in the cognitive traits considered, with the proportion varying widely across traits (range, 9-95%). We distil genetic loci that are broadly relevant for many cognitive traits (g) from loci associated specifically with individual cognitive traits. These results contribute to elucidating the aetiology of a long-known yet poorly understood phenomenon, revealing a fundamental dimension of genetic sharing across diverse cognitive traits.

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Year:  2020        PMID： 32895543      PMCID： PMC9346507          DOI： 10.1038/s41562-020-00936-2

Source DB:  PubMed          Journal:  Nat Hum Behav        ISSN： 2397-3374


  43 in total

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Authors:  Jian Yang; S Hong Lee; Michael E Goddard; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2010-12-17       Impact factor: 11.025

2.  A dynamical model of general intelligence: the positive manifold of intelligence by mutualism.

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Journal:  Psychol Rev       Date:  2006-10       Impact factor: 8.934

3.  Coupled cognitive changes in adulthood: A meta-analysis.

Authors:  Elliot M Tucker-Drob; Andreas M Brandmaier; Ulman Lindenberger
Journal:  Psychol Bull       Date:  2019-01-24       Impact factor: 17.737

4.  Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

Authors:  Jeanne E Savage; Philip R Jansen; Sven Stringer; Kyoko Watanabe; Julien Bryois; Christiaan A de Leeuw; Mats Nagel; Swapnil Awasthi; Peter B Barr; Jonathan R I Coleman; Katrina L Grasby; Anke R Hammerschlag; Jakob A Kaminski; Robert Karlsson; Eva Krapohl; Max Lam; Marianne Nygaard; Chandra A Reynolds; Joey W Trampush; Hannah Young; Delilah Zabaneh; Sara Hägg; Narelle K Hansell; Ida K Karlsson; Sten Linnarsson; Grant W Montgomery; Ana B Muñoz-Manchado; Erin B Quinlan; Gunter Schumann; Nathan G Skene; Bradley T Webb; Tonya White; Dan E Arking; Dimitrios Avramopoulos; Robert M Bilder; Panos Bitsios; Katherine E Burdick; Tyrone D Cannon; Ornit Chiba-Falek; Andrea Christoforou; Elizabeth T Cirulli; Eliza Congdon; Aiden Corvin; Gail Davies; Ian J Deary; Pamela DeRosse; Dwight Dickinson; Srdjan Djurovic; Gary Donohoe; Emily Drabant Conley; Johan G Eriksson; Thomas Espeseth; Nelson A Freimer; Stella Giakoumaki; Ina Giegling; Michael Gill; David C Glahn; Ahmad R Hariri; Alex Hatzimanolis; Matthew C Keller; Emma Knowles; Deborah Koltai; Bettina Konte; Jari Lahti; Stephanie Le Hellard; Todd Lencz; David C Liewald; Edythe London; Astri J Lundervold; Anil K Malhotra; Ingrid Melle; Derek Morris; Anna C Need; William Ollier; Aarno Palotie; Antony Payton; Neil Pendleton; Russell A Poldrack; Katri Räikkönen; Ivar Reinvang; Panos Roussos; Dan Rujescu; Fred W Sabb; Matthew A Scult; Olav B Smeland; Nikolaos Smyrnis; John M Starr; Vidar M Steen; Nikos C Stefanis; Richard E Straub; Kjetil Sundet; Henning Tiemeier; Aristotle N Voineskos; Daniel R Weinberger; Elisabeth Widen; Jin Yu; Goncalo Abecasis; Ole A Andreassen; Gerome Breen; Lene Christiansen; Birgit Debrabant; Danielle M Dick; Andreas Heinz; Jens Hjerling-Leffler; M Arfan Ikram; Kenneth S Kendler; Nicholas G Martin; Sarah E Medland; Nancy L Pedersen; Robert Plomin; Tinca J C Polderman; Stephan Ripke; Sophie van der Sluis; Patrick F Sullivan; Scott I Vrieze; Margaret J Wright; Danielle Posthuma
Journal:  Nat Genet       Date:  2018-06-25       Impact factor: 38.330

5.  Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.

Authors:  Ditte Demontis; Raymond K Walters; Joanna Martin; Manuel Mattheisen; Thomas D Als; Esben Agerbo; Gísli Baldursson; Rich Belliveau; Jonas Bybjerg-Grauholm; Marie Bækvad-Hansen; Felecia Cerrato; Kimberly Chambert; Claire Churchhouse; Ashley Dumont; Nicholas Eriksson; Michael Gandal; Jacqueline I Goldstein; Katrina L Grasby; Jakob Grove; Olafur O Gudmundsson; Christine S Hansen; Mads Engel Hauberg; Mads V Hollegaard; Daniel P Howrigan; Hailiang Huang; Julian B Maller; Alicia R Martin; Nicholas G Martin; Jennifer Moran; Jonatan Pallesen; Duncan S Palmer; Carsten Bøcker Pedersen; Marianne Giørtz Pedersen; Timothy Poterba; Jesper Buchhave Poulsen; Stephan Ripke; Elise B Robinson; F Kyle Satterstrom; Hreinn Stefansson; Christine Stevens; Patrick Turley; G Bragi Walters; Hyejung Won; Margaret J Wright; Ole A Andreassen; Philip Asherson; Christie L Burton; Dorret I Boomsma; Bru Cormand; Søren Dalsgaard; Barbara Franke; Joel Gelernter; Daniel Geschwind; Hakon Hakonarson; Jan Haavik; Henry R Kranzler; Jonna Kuntsi; Kate Langley; Klaus-Peter Lesch; Christel Middeldorp; Andreas Reif; Luis Augusto Rohde; Panos Roussos; Russell Schachar; Pamela Sklar; Edmund J S Sonuga-Barke; Patrick F Sullivan; Anita Thapar; Joyce Y Tung; Irwin D Waldman; Sarah E Medland; Kari Stefansson; Merete Nordentoft; David M Hougaard; Thomas Werge; Ole Mors; Preben Bo Mortensen; Mark J Daly; Stephen V Faraone; Anders D Børglum; Benjamin M Neale
Journal:  Nat Genet       Date:  2018-11-26       Impact factor: 38.330

6.  METAL: fast and efficient meta-analysis of genomewide association scans.

Authors:  Cristen J Willer; Yun Li; Gonçalo R Abecasis
Journal:  Bioinformatics       Date:  2010-07-08       Impact factor: 6.937

7.  Functional mapping and annotation of genetic associations with FUMA.

Authors:  Kyoko Watanabe; Erdogan Taskesen; Arjen van Bochoven; Danielle Posthuma
Journal:  Nat Commun       Date:  2017-11-28       Impact factor: 14.919

8.  Generalist genes: implications for the cognitive sciences.

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9.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Authors:  J C Lambert; C A Ibrahim-Verbaas; D Harold; A C Naj; R Sims; C Bellenguez; A L DeStafano; J C Bis; G W Beecham; B Grenier-Boley; G Russo; T A Thorton-Wells; N Jones; A V Smith; V Chouraki; C Thomas; M A Ikram; D Zelenika; B N Vardarajan; Y Kamatani; C F Lin; A Gerrish; H Schmidt; B Kunkle; M L Dunstan; A Ruiz; M T Bihoreau; S H Choi; C Reitz; F Pasquier; C Cruchaga; D Craig; N Amin; C Berr; O L Lopez; P L De Jager; V Deramecourt; J A Johnston; D Evans; S Lovestone; L Letenneur; F J Morón; D C Rubinsztein; G Eiriksdottir; K Sleegers; A M Goate; N Fiévet; M W Huentelman; M Gill; K Brown; M I Kamboh; L Keller; P Barberger-Gateau; B McGuiness; E B Larson; R Green; A J Myers; C Dufouil; S Todd; D Wallon; S Love; E Rogaeva; J Gallacher; P St George-Hyslop; J Clarimon; A Lleo; A Bayer; D W Tsuang; L Yu; M Tsolaki; P Bossù; G Spalletta; P Proitsi; J Collinge; S Sorbi; F Sanchez-Garcia; N C Fox; J Hardy; M C Deniz Naranjo; P Bosco; R Clarke; C Brayne; D Galimberti; M Mancuso; F Matthews; S Moebus; P Mecocci; M Del Zompo; W Maier; H Hampel; A Pilotto; M Bullido; F Panza; P Caffarra; B Nacmias; J R Gilbert; M Mayhaus; L Lannefelt; H Hakonarson; S Pichler; M M Carrasquillo; M Ingelsson; D Beekly; V Alvarez; F Zou; O Valladares; S G Younkin; E Coto; K L Hamilton-Nelson; W Gu; C Razquin; P Pastor; I Mateo; M J Owen; K M Faber; P V Jonsson; O Combarros; M C O'Donovan; L B Cantwell; H Soininen; D Blacker; S Mead; T H Mosley; D A Bennett; T B Harris; L Fratiglioni; C Holmes; R F de Bruijn; P Passmore; T J Montine; K Bettens; J I Rotter; A Brice; K Morgan; T M Foroud; W A Kukull; D Hannequin; J F Powell; M A Nalls; K Ritchie; K L Lunetta; J S Kauwe; E Boerwinkle; M Riemenschneider; M Boada; M Hiltuenen; E R Martin; R Schmidt; D Rujescu; L S Wang; J F Dartigues; R Mayeux; C Tzourio; A Hofman; M M Nöthen; C Graff; B M Psaty; L Jones; J L Haines; P A Holmans; M Lathrop; M A Pericak-Vance; L J Launer; L A Farrer; C M van Duijn; C Van Broeckhoven; V Moskvina; S Seshadri; J Williams; G D Schellenberg; P Amouyel
Journal:  Nat Genet       Date:  2013-10-27       Impact factor: 38.330

10.  Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia.

Authors:  S P Hagenaars; S E Harris; G Davies; W D Hill; D C M Liewald; S J Ritchie; R E Marioni; C Fawns-Ritchie; B Cullen; R Malik; B B Worrall; C L M Sudlow; J M Wardlaw; J Gallacher; J Pell; A M McIntosh; D J Smith; C R Gale; I J Deary
Journal:  Mol Psychiatry       Date:  2016-01-26       Impact factor: 15.992
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  4 in total

1.  Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits.

Authors:  Andrew D Grotzinger; Javier de la Fuente; Gail Davies; Michel G Nivard; Elliot M Tucker-Drob
Journal:  Nat Commun       Date:  2022-10-21       Impact factor: 17.694

2.  Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.

Authors:  Richard Karlsson Linnér; Travis T Mallard; Peter B Barr; Sandra Sanchez-Roige; James W Madole; Morgan N Driver; Holly E Poore; Ronald de Vlaming; Andrew D Grotzinger; Jorim J Tielbeek; Emma C Johnson; Mengzhen Liu; Sara Brin Rosenthal; Trey Ideker; Hang Zhou; Rachel L Kember; Joëlle A Pasman; Karin J H Verweij; Dajiang J Liu; Scott Vrieze; Henry R Kranzler; Joel Gelernter; Kathleen Mullan Harris; Elliot M Tucker-Drob; Irwin D Waldman; Abraham A Palmer; K Paige Harden; Philipp D Koellinger; Danielle M Dick
Journal:  Nat Neurosci       Date:  2021-08-26       Impact factor: 24.884

3.  Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region.

Authors:  Javier de la Fuente; Andrew D Grotzinger; Riccardo E Marioni; Michel G Nivard; Elliot M Tucker-Drob
Journal:  PLoS Genet       Date:  2022-06-03       Impact factor: 6.020

Review 4.  Intelligence, health and death.

Authors:  Ian J Deary; W David Hill; Catharine R Gale
Journal:  Nat Hum Behav       Date:  2021-04-01
  4 in total

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