| Literature DB >> 32895515 |
Mengdi Han1, Lin Chen2,3, Kedar Aras4, Cunman Liang5, Xuexian Chen6, Hangbo Zhao1,7, Kan Li2,8,9,10, Ndeye Rokhaya Faye4, Bohan Sun1,11, Jae-Hwan Kim12,13, Wubin Bai1,9, Quansan Yang8, Yuhang Ma1,14, Wei Lu1, Enming Song1, Janice Mihyun Baek15, Yujin Lee15, Clifford Liu1, Jeffrey B Model1, Guanjun Yang3, Roozbeh Ghaffari1,16, Yonggang Huang17,18,19,20, Igor R Efimov21, John A Rogers22,23,24,25,26,27,28,29.
Abstract
The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes.Entities:
Mesh：
Year: 2020 PMID： 32895515 PMCID： PMC8021456 DOI： 10.1038/s41551-020-00604-w
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671