Ji-Hye Roh1, Sangjin Lee2, Jeong-Hyun Yoon1. 1. Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea. 2. Department of Statistics, College of Natural Science, Pusan National University, Busan, Republic of Korea.
Abstract
Background: Metabolic syndrome (MetS) and Parkinson's disease (PD) share common pathophysiological mechanisms. This study aimed to investigate the influence of MetS on PD incidence. Materials and Methods: A propensity score-matched cohort study was conducted using the National Health Insurance Service-National Health Screening Cohort (NHIS-HealS) data (2002-2015) from the Korean National Health Insurance Service. Individuals with MetS were identified from those who underwent a health checkup in 2009-2010 and were 1:1 matched to individuals without MetS (non-MetS) using the propensity score method. Among 314,737 eligible individuals, 85,530 MetS and non-MetS pairs were selected. Results: During a mean follow-up of 7.23 years, 819 (0.48%) PD cases occurred. Individuals with MetS exhibited 1.23 times greater PD incidence (95% confidence interval [CI], 1.06-1.43; P = 0.006). The risk of PD increased with the number of MetS components, with the presence of five MetS components altogether doubling the incidence of PD (odds ratio [OR], 2.00; 95% CI, 1.30-3.04; P = 0.001). High blood pressure, low high-density lipoprotein cholesterol, and high fasting blood glucose increased PD incidence by 1.34 times (95% CI, 1.15-1.58; P < 0.001), 1.31 times (95% CI, 1.13-1.52; P < 0.001), and 1.20 times (95% CI, 1.04-1.38; P = 0.013), respectively. Elevated waist circumference was not associated with PD incidence (OR, 1.11; 95% CI, 0.96-1.28; P = 0.176). High triglycerides exerted a protective effect against PD incidence especially in men (OR, 0.66; 95% CI, 0.54-0.81; P < 0.001). Conclusions: MetS may be a risk factor for PD incidence, and individual components of MetS exert different effects depending on sex.
Background: Metabolic syndrome (MetS) and Parkinson's disease (PD) share common pathophysiological mechanisms. This study aimed to investigate the influence of MetS on PD incidence. Materials and Methods: A propensity score-matched cohort study was conducted using the National Health Insurance Service-National Health Screening Cohort (NHIS-HealS) data (2002-2015) from the Korean National Health Insurance Service. Individuals with MetS were identified from those who underwent a health checkup in 2009-2010 and were 1:1 matched to individuals without MetS (non-MetS) using the propensity score method. Among 314,737 eligible individuals, 85,530 MetS and non-MetS pairs were selected. Results: During a mean follow-up of 7.23 years, 819 (0.48%) PD cases occurred. Individuals with MetS exhibited 1.23 times greater PD incidence (95% confidence interval [CI], 1.06-1.43; P = 0.006). The risk of PD increased with the number of MetS components, with the presence of five MetS components altogether doubling the incidence of PD (odds ratio [OR], 2.00; 95% CI, 1.30-3.04; P = 0.001). High blood pressure, low high-density lipoprotein cholesterol, and high fasting blood glucose increased PD incidence by 1.34 times (95% CI, 1.15-1.58; P < 0.001), 1.31 times (95% CI, 1.13-1.52; P < 0.001), and 1.20 times (95% CI, 1.04-1.38; P = 0.013), respectively. Elevated waist circumference was not associated with PD incidence (OR, 1.11; 95% CI, 0.96-1.28; P = 0.176). High triglycerides exerted a protective effect against PD incidence especially in men (OR, 0.66; 95% CI, 0.54-0.81; P < 0.001). Conclusions: MetS may be a risk factor for PD incidence, and individual components of MetS exert different effects depending on sex.
Authors: Ana Patrícia da Silva Souza; Waleska Maria Almeida Barros; José Maurício Lucas Silva; Mariluce Rodrigues Marques Silva; Ana Beatriz Januário Silva; Matheus Santos de Sousa Fernandes; Maria Eduarda Rodrigues Alves Dos Santos; Mayara Luclécia da Silva; Taciane Silva do Carmo; Roberta Karlize Pereira Silva; Karollainy Gomes da Silva; Sandra Lopes de Souza; Viviane de Oliveira Nogueira Souza Journal: Clinics (Sao Paulo) Date: 2021-12-13 Impact factor: 2.365