Alida M Gertz1, Ian J Bishop2, Boikhutso Simon3, Kwana Lechiile4, Opelo Badubi3, Aamirah Mussa3, Carolyn L Westhoff2, Chelsea Morroni5. 1. Botswana-University of Pennsylvania Partnership, University of Botswana Main, Campus 244G - Room 103, Gaborone, Botswana; Afya Bora Consortium Fellowship Program, United States; Botswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana. 2. Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, United States. 3. Botswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana. 4. Botswana-University of Pennsylvania Partnership, University of Botswana Main, Campus 244G - Room 103, Gaborone, Botswana. 5. Botswana-University of Pennsylvania Partnership, University of Botswana Main, Campus 244G - Room 103, Gaborone, Botswana; Botswana Harvard Partnership, Private Bag BO 320, Gaborone, Botswana; Liverpool School of Tropical Medicine, Pembroke Pl, Liverpool L3 5QA, United Kingdom. Electronic address: chelsea.morroni@lstmed.ac.uk.
Abstract
OBJECTIVE: To compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm. STUDY DESIGN: Sub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples. RESULTS: Plasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.99; p < 0.0001). Bland-Altman analysis of agreement showed that etonogestrel levels were on average 5.9 pg/mL higher (2.1%) in ipsilateral compared to contralateral specimens (95% confidence interval: -4.1, 15.9 pg/mL). CONCLUSIONS: We found no meaningful differences in plasma etonogestrel concentrations between samples taken from the contralateral- versus ipsilateral-to-implant arm. IMPLICATIONS: Our data suggest that etonogestrel plasma concentrations are unlikely to be meaningfully different between samples drawn from the ipsilateral- versus the contralateral-to-implant arms in etonogestrel contraceptive implant users.
OBJECTIVE: To compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm. STUDY DESIGN: Sub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples. RESULTS: Plasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.99; p < 0.0001). Bland-Altman analysis of agreement showed that etonogestrel levels were on average 5.9 pg/mL higher (2.1%) in ipsilateral compared to contralateral specimens (95% confidence interval: -4.1, 15.9 pg/mL). CONCLUSIONS: We found no meaningful differences in plasma etonogestrel concentrations between samples taken from the contralateral- versus ipsilateral-to-implant arm. IMPLICATIONS: Our data suggest that etonogestrel plasma concentrations are unlikely to be meaningfully different between samples drawn from the ipsilateral- versus the contralateral-to-implant arms in etonogestrel contraceptive implant users.
Authors: Catherine A Chappell; Mohammed Lamorde; Shadia Nakalema; Beatrice A Chen; Hope Mackline; Sharon A Riddler; Susan E Cohn; Kristin M Darin; Sharon L Achilles; Kimberly K Scarsi Journal: AIDS Date: 2017-09-10 Impact factor: 4.177
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