Literature DB >> 3280976

DNA sequence analysis of spontaneous mutations in the SUP4-o gene of Saccharomyces cerevisiae.

C N Giroux1, J R Mis, M K Pierce, S E Kohalmi, B A Kunz.   

Abstract

A collection of 196 spontaneous mutations in the SUP4-o gene of the yeast Saccharomyces cerevisiae was analyzed by DNA sequencing. The classes of mutation identified included all possible types of base-pair substitution, deletions of various lengths, complex alterations involving multiple changes, and insertions of transposable elements. Our findings demonstrate that at least several different mechanisms are responsible for spontaneous mutagenesis in S. cerevisiae.

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Year:  1988        PMID： 3280976      PMCID： PMC363231          DOI： 10.1128/mcb.8.2.978-981.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  18 in total

1.  Transcription and processing of intervening sequences in yeast tRNA genes.

Authors:  G Knapp; J S Beckmann; P F Johnson; S A Fuhrman; J Abelson
Journal:  Cell       Date:  1978-06       Impact factor: 41.582

2.  Protein synthesis directed by DNA phage messengers.

Authors:  G N Gussin; M R Capecchi; J M Adams; J E Argetsinger; J Tooze; K Weber; J D Watson
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1966

3.  Transposable elements (Ty) in yeast.

Authors:  G Fink; P Farabaugh; G Roeder; D Chaleff
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1981

4.  The yeast transposon Ty1 generates duplications of target DNA on insertion.

Authors:  J Gafner; P Philippsen
Journal:  Nature       Date:  1980-07-24       Impact factor: 49.962

5.  Unique self-complementarity of palindromic sequences provides DNA structural intermediates for mutation.

Authors:  L S Ripley; B W Glickman
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1983

Review 6.  Mutagenesis in Saccharomyces cerevisiae.

Authors:  C W Lawrence
Journal:  Adv Genet       Date:  1982       Impact factor: 1.944

7.  Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression.

Authors:  V M Williamson; D Cox; E T Young; D W Russell; M Smith
Journal:  Mol Cell Biol       Date:  1983-01       Impact factor: 4.272

8.  Development of a yeast system to assay mutational specificity.

Authors:  M K Pierce; C N Giroux; B A Kunz
Journal:  Mutat Res       Date:  1987-04       Impact factor: 2.433

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Mutations at the yeast SUP4 tRNATyr locus: DNA sequence changes in mutants lacking suppressor activity.

Authors:  J Kurjan; B D Hall; S Gillam; M Smith
Journal:  Cell       Date:  1980-07       Impact factor: 41.582
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  31 in total

1.  Ectopic recombination between Ty elements in Saccharomyces cerevisiae is not induced by DNA damage.

Authors:  A Parket; M Kupiec
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

2.  A tester system for detecting each of the six base-pair substitutions in Saccharomyces cerevisiae by selecting for an essential cysteine in iso-1-cytochrome c.

Authors:  M Hampsey
Journal:  Genetics       Date:  1991-05       Impact factor: 4.562

Review 3.  The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions.

Authors:  D N Cooper; M Krawczak
Journal:  Hum Genet       Date:  1990-06       Impact factor: 4.132

4.  Frameshift errors initiated by nucleotide misincorporation.

Authors:  K Bebenek; T A Kunkel
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

5.  Ty1 transposition in Saccharomyces cerevisiae is nonrandom.

Authors:  G Natsoulis; W Thomas; M C Roghmann; F Winston; J D Boeke
Journal:  Genetics       Date:  1989-10       Impact factor: 4.562

6.  Analysis of yeast retrotransposon Ty insertions at the CAN1 locus.

Authors:  C M Wilke; S H Heidler; N Brown; S W Liebman
Journal:  Genetics       Date:  1989-12       Impact factor: 4.562

7.  The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance.

Authors:  N Vaisman; A Tsouladze; K Robzyk; S Ben-Yehuda; M Kupiec; Y Kassir
Journal:  Mol Gen Genet       Date:  1995-04-20

8.  Single-step selection for Ty1 element retrotransposition.

Authors:  M J Curcio; D J Garfinkel
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

9.  Disruption of the RAD52 gene alters the spectrum of spontaneous SUP4-o mutations in Saccharomyces cerevisiae.

Authors:  B A Kunz; M G Peters; S E Kohalmi; J D Armstrong; M Glattke; K Badiani
Journal:  Genetics       Date:  1989-07       Impact factor: 4.562

10.  Enhanced canavanine uptake is associated with nucleotide permeability in a thymidylate auxotroph of Saccharomyces cerevisiae.

Authors:  S E Kohalmi; B A Kunz
Journal:  Curr Genet       Date:  1989-02       Impact factor: 3.886
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