Cindy H Nabuurs1,2, Wietske Kievit1,2,3, Nilou Labbé1, C René Leemans4, Conrad F G M Smit4, Michiel W M van den Brekel5, Robert J Pauw6, Bernard F A M van der Laan7, Jeroen C Jansen8, Martin Lacko9, Weibel W Braunius10, Shinya Morita11, Małgorzata Wierzbicka12, Takuma Matoba13,14, Nobuhiro Hanai14, Robert P Takes1,2, Henricus P M Kunst1,2,9. 1. Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. 2. Rare Cancers, Radboud Institute for Health Sciences, Nijmegen, The Netherlands. 3. Department of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands. 4. Department of Otolaryngology-Head and Neck Surgery, Amsterdam University Medical Centers, VU University, Amsterdam, The Netherlands. 5. Department of Head and Neck Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands. 6. Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. 7. Department of Otorhinolaryngology and Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 8. Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands. 9. Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. 10. Department of Head and Neck Surgical Oncology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands. 11. Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 12. ENT Department, Medical University, Pozna'n, Poland. 13. Department of Otorhinolaryngology and Head and Neck Surgery, Nagoya City University Hospital, Nagoya, Aichi, Japan. 14. Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
Abstract
BACKGROUND: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). METHODS: We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. RESULTS: A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. CONCLUSION: The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.
BACKGROUND:Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). METHODS: We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. RESULTS: A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. CONCLUSION: The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.
Authors: Michael G Moore; Daniel G Deschler; Michael J McKenna; Mark A Varvares; Derrick T Lin Journal: Otolaryngol Head Neck Surg Date: 2007-12 Impact factor: 3.497
Authors: Conrad F Smit; Niels de Boer; Birgit I Lissenberg-Witte; Paul Merkus; Erik F Hensen; C René Leemans Journal: Acta Otorhinolaryngol Ital Date: 2021-08 Impact factor: 2.124
Authors: Cindy H Nabuurs; Wietske Kievit; Nilou Labbé; C René Leemans; Conrad F G M Smit; Michiel W M van den Brekel; Robert J Pauw; Bernard F A M van der Laan; Jeroen C Jansen; Martin Lacko; Weibel W Braunius; Shinya Morita; Małgorzata Wierzbicka; Takuma Matoba; Nobuhiro Hanai; Robert P Takes; Henricus P M Kunst Journal: Head Neck Date: 2020-08-13 Impact factor: 3.147