Literature DB >> 32792144

Atomic Structures of Amyloid-β Oligomers Illuminate a Neurotoxic Mechanism.

April L Darling1, James Shorter2.   

Abstract

Amyloid-β (Aβ) accumulation in the brain is a cardinal event in Alzheimer's disease (AD), but the structural basis of Aβ-elicited neurotoxicity is unknown. In a recent paper, Ciudad et al. elucidate the first atomic structures of Aβ oligomers, which reveal how they form lipid-stabilized pores that might disrupt neuronal membranes and ion homeostasis.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; amyloid-β; pore-forming oligomer

Mesh：

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Year:  2020        PMID： 32792144      PMCID： PMC7935414          DOI： 10.1016/j.tins.2020.07.006

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  10 in total

1.  Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity.

Authors:  Ali Reza A Ladiwala; Jeffrey Litt; Ravi S Kane; Darryl S Aucoin; Steven O Smith; Swarnim Ranjan; Judianne Davis; William E Van Nostrand; Peter M Tessier
Journal:  J Biol Chem       Date:  2012-04-30       Impact factor: 5.157

Review 2.  Cryo-EM structures of tau filaments.

Authors:  Sjors Hw Scheres; Wenjuan Zhang; Benjamin Falcon; Michel Goedert
Journal:  Curr Opin Struct Biol       Date:  2020-06-27       Impact factor: 6.809

3.  The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Authors:  Jeff Sevigny; Ping Chiao; Thierry Bussière; Paul H Weinreb; Leslie Williams; Marcel Maier; Robert Dunstan; Stephen Salloway; Tianle Chen; Yan Ling; John O'Gorman; Fang Qian; Mahin Arastu; Mingwei Li; Sowmya Chollate; Melanie S Brennan; Omar Quintero-Monzon; Robert H Scannevin; H Moore Arnold; Thomas Engber; Kenneth Rhodes; James Ferrero; Yaming Hang; Alvydas Mikulskis; Jan Grimm; Christoph Hock; Roger M Nitsch; Alfred Sandrock
Journal:  Nature       Date:  2016-09-01       Impact factor: 49.962

4.  Kinetic diversity of amyloid oligomers.

Authors:  Alexander J Dear; Thomas C T Michaels; Georg Meisl; David Klenerman; Si Wu; Sarah Perrett; Sara Linse; Christopher M Dobson; Tuomas P J Knowles
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-15       Impact factor: 11.205

Review 5.  The ability of amyloid beta-protein [A beta P (1-40)] to form Ca2+ channels provides a mechanism for neuronal death in Alzheimer's disease.

Authors:  N Arispe; H B Pollard; E Rojas
Journal:  Ann N Y Acad Sci       Date:  1994-12-15       Impact factor: 5.691

6.  Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments.

Authors:  Montserrat Serra-Batiste; Martí Ninot-Pedrosa; Mariam Bayoumi; Margarida Gairí; Giovanni Maglia; Natàlia Carulla
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-12       Impact factor: 11.205

7.  Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

Authors:  N Arispe; E Rojas; H B Pollard
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

Review 8.  Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.

Authors:  Fuyuki Kametani; Masato Hasegawa
Journal:  Front Neurosci       Date:  2018-01-30       Impact factor: 4.677

Review 9.  The amyloid hypothesis of Alzheimer's disease at 25 years.

Authors:  Dennis J Selkoe; John Hardy
Journal:  EMBO Mol Med       Date:  2016-06-01       Impact factor: 12.137

10.  Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.

Authors:  Sonia Ciudad; Eduard Puig; Thomas Botzanowski; Moeen Meigooni; Andres S Arango; Jimmy Do; Maxim Mayzel; Mariam Bayoumi; Stéphane Chaignepain; Giovanni Maglia; Sarah Cianferani; Vladislav Orekhov; Emad Tajkhorshid; Benjamin Bardiaux; Natàlia Carulla
Journal:  Nat Commun       Date:  2020-06-15       Impact factor: 14.919
  10 in total
  4 in total

1.  Gastrointestinal (GI)-Tract Microbiome Derived Neurotoxins and their Potential Contribution to Inflammatory Neurodegeneration in Alzheimer's Disease (AD).

Authors:  Walter J Lukiw; Lisa Arceneaux; Wenhong Li; Taylor Bond; Yuhai Zhao
Journal:  J Alzheimers Dis Parkinsonism       Date:  2021-05-25

Review 2.  Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms.

Authors:  Katiuscia Pagano; Simona Tomaselli; Henriette Molinari; Laura Ragona
Journal:  Front Neurosci       Date:  2020-12-22       Impact factor: 4.677

3.  Side Chain Geometry Determines the Fibrillation Propensity of a Minimal Two-Beads-per-Residue Peptide Model.

Authors:  Beata Szała-Mendyk; Andrzej Molski
Journal:  J Phys Chem B       Date:  2022-08-02       Impact factor: 3.466

4.  Novel Peptide-Calix[4]arene Conjugate Inhibits Aβ Aggregation and Rescues Neurons from Aβ's Oligomers Cytotoxicity In Vitro.

Authors:  Grazia Maria Letizia Consoli; Rita Tosto; Ausilia Baglieri; Salvatore Petralia; Tiziana Campagna; Giuseppe Di Natale; Stefania Zimbone; Maria Laura Giuffrida; Giuseppe Pappalardo
Journal:  ACS Chem Neurosci       Date:  2021-04-12       Impact factor: 5.780
  4 in total

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