Literature DB >> 32790898

A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase.

Catherine H Freudenreich1.   

Abstract

How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G-quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.
© 2020 The Author.

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Year:  2020        PMID： 32790898      PMCID： PMC7507315          DOI： 10.15252/embj.2020106305

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  14 in total

1.  Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins.

Authors:  Irina Voineagu; Vidhya Narayanan; Kirill S Lobachev; Sergei M Mirkin
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-15       Impact factor: 11.205

2.  A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase.

Authors:  Catherine H Freudenreich
Journal:  EMBO J       Date:  2020-08-13       Impact factor: 11.598

Review 3.  On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.

Authors:  Alexandra N Khristich; Sergei M Mirkin
Journal:  J Biol Chem       Date:  2020-02-14       Impact factor: 5.157

4.  Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability.

Authors:  Guoqi Liu; Xiaomi Chen; Yanzhe Gao; Todd Lewis; Joanna Barthelemy; Michael Leffak
Journal:  Mol Cell Biol       Date:  2012-02-21       Impact factor: 4.272

5.  Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.

Authors:  Irina Voineagu; Christine F Surka; Alexander A Shishkin; Maria M Krasilnikova; Sergei M Mirkin
Journal:  Nat Struct Mol Biol       Date:  2009-01-11       Impact factor: 15.369

6.  How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication.

Authors:  Joseph T P Yeeles; Agnieska Janska; Anne Early; John F X Diffley
Journal:  Mol Cell       Date:  2016-12-15       Impact factor: 17.970

7.  Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.

Authors:  Julien N Bianco; Valérie Bergoglio; Yea-Lih Lin; Marie-Jeanne Pillaire; Anne-Lyne Schmitz; Julia Gilhodes; Amelie Lusque; Julien Mazières; Magali Lacroix-Triki; Theodoros I Roumeliotis; Jyoti Choudhary; Jérôme Moreaux; Jean-Sébastien Hoffmann; Hélène Tourrière; Philippe Pasero
Journal:  Nat Commun       Date:  2019-02-22       Impact factor: 14.919

8.  Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function.

Authors:  Lionel Gellon; Simran Kaushal; Jorge Cebrián; Mayurika Lahiri; Sergei M Mirkin; Catherine H Freudenreich
Journal:  Nucleic Acids Res       Date:  2019-01-25       Impact factor: 16.971

9.  Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.

Authors:  Leticia K Lerner; Sandro Holzer; Mairi L Kilkenny; Saša Šviković; Pierre Murat; Davide Schiavone; Cara B Eldridge; Alice Bittleston; Joseph D Maman; Dana Branzei; Katherine Stott; Luca Pellegrini; Julian E Sale
Journal:  EMBO J       Date:  2020-07-23       Impact factor: 11.598

10.  Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.

Authors:  Federica Calì; Sanjay Kumar Bharti; Roberta Di Perna; Robert M Brosh; Francesca M Pisani
Journal:  Nucleic Acids Res       Date:  2015-10-25       Impact factor: 16.971
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  1 in total

1.  A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase.

Authors:  Catherine H Freudenreich
Journal:  EMBO J       Date:  2020-08-13       Impact factor: 11.598
  1 in total

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