Literature DB >> 19136957

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.

Irina Voineagu1, Christine F Surka, Alexander A Shishkin, Maria M Krasilnikova, Sergei M Mirkin.   

Abstract

Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, the fork-stabilizing role of Mrc1 does not involve its checkpoint function. Thus, chromosomal fragility might occur when forks stalled at expanded CGG repeats escape the S-phase checkpoint.

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Year:  2009        PMID： 19136957      PMCID： PMC2837601          DOI： 10.1038/nsmb.1527

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  20 in total

1.  Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

Authors:  Alexander J Osborn; Stephen J Elledge
Journal:  Genes Dev       Date:  2003-07-15       Impact factor: 11.361

2.  Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases.

Authors:  Catherine H Freudenreich; Mayurika Lahiri
Journal:  Cell Cycle       Date:  2004-11-15       Impact factor: 4.534

3.  S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

Authors:  Yuki Katou; Yutaka Kanoh; Masashige Bando; Hideki Noguchi; Hirokazu Tanaka; Toshihiko Ashikari; Katsunori Sugimoto; Katsuhiko Shirahige
Journal:  Nature       Date:  2003-08-28       Impact factor: 49.962

4.  CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.

Authors:  K Usdin; K J Woodford
Journal:  Nucleic Acids Res       Date:  1995-10-25       Impact factor: 16.971

5.  Trinucleotide repeats that expand in human disease form hairpin structures in vitro.

Authors:  A M Gacy; G Goellner; N Juranić; S Macura; C T McMurray
Journal:  Cell       Date:  1995-05-19       Impact factor: 41.582

6.  Association of fragile X syndrome with delayed replication of the FMR1 gene.

Authors:  R S Hansen; T K Canfield; M M Lamb; S M Gartler; C D Laird
Journal:  Cell       Date:  1993-07-02       Impact factor: 41.582

7.  Trinucleotide repeats affect DNA replication in vivo.

Authors:  G M Samadashwily; G Raca; S M Mirkin
Journal:  Nat Genet       Date:  1997-11       Impact factor: 38.330

8.  Role of replication and CpG methylation in fragile X syndrome CGG deletions in primate cells.

Authors:  Kerrie Nichol Edamura; Michelle R Leonard; Christopher E Pearson
Journal:  Am J Hum Genet       Date:  2004-12-29       Impact factor: 11.025

9.  Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes.

Authors:  S Kang; K Ohshima; M Shimizu; S Amirhaeri; R D Wells
Journal:  J Biol Chem       Date:  1995-11-10       Impact factor: 5.157

10.  The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.

Authors:  M Fry; L A Loeb
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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  79 in total

1.  Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.

Authors:  Taku Tanaka; Mika Yokoyama; Seiji Matsumoto; Rino Fukatsu; Zhiying You; Hisao Masai
Journal:  J Biol Chem       Date:  2010-10-05       Impact factor: 5.157

2.  Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.

Authors:  Motoshi Hayano; Yutaka Kanoh; Seiji Matsumoto; Hisao Masai
Journal:  Mol Cell Biol       Date:  2011-04-25       Impact factor: 4.272

3.  Rif1 is a global regulator of timing of replication origin firing in fission yeast.

Authors:  Motoshi Hayano; Yutaka Kanoh; Seiji Matsumoto; Claire Renard-Guillet; Katsuhiko Shirahige; Hisao Masai
Journal:  Genes Dev       Date:  2012-01-15       Impact factor: 11.361

4.  Timeless preserves telomere length by promoting efficient DNA replication through human telomeres.

Authors:  Adam R Leman; Jayaraju Dheekollu; Zhong Deng; Seung Woo Lee; Mukund M Das; Paul M Lieberman; Eishi Noguchi
Journal:  Cell Cycle       Date:  2012-06-15       Impact factor: 4.534

5.  Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats.

Authors:  Aarthy C Vallur; Nancy Maizels
Journal:  J Biol Chem       Date:  2010-07-19       Impact factor: 5.157

6.  Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia.

Authors:  Daman Kumari; Bruce Hayward; Asako J Nakamura; William M Bonner; Karen Usdin
Journal:  Mutat Res       Date:  2015-08-30       Impact factor: 2.433

7.  Chromatin assembly controls replication fork stability.

Authors:  Marta Clemente-Ruiz; Félix Prado
Journal:  EMBO Rep       Date:  2009-05-22       Impact factor: 8.807

8.  G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.

Authors:  Mridula Nambiar; Mrinal Srivastava; Vidya Gopalakrishnan; Sritha K Sankaran; Sathees C Raghavan
Journal:  Mol Cell Biol       Date:  2013-09-03       Impact factor: 4.272

9.  The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells.

Authors:  Jeannine Gerhardt; Mark J Tomishima; Nikica Zaninovic; Dilek Colak; Zi Yan; Qiansheng Zhan; Zev Rosenwaks; Samie R Jaffrey; Carl L Schildkraut
Journal:  Mol Cell       Date:  2013-11-27       Impact factor: 17.970

10.  Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions.

Authors:  Cindy Follonier; Judith Oehler; Raquel Herrador; Massimo Lopes
Journal:  Nat Struct Mol Biol       Date:  2013-03-03       Impact factor: 15.369
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