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Literature DB >> 32781308

Second to fourth digit ratio (2D:4D) is associated with dementia in women.

Joanne Jiang¹, Katherine Young¹, Christian J Pike².

Abstract

Alzheimer's disease is characterized by sex differences that may involve sex hormone exposure during development. Finger length ratios, an indirect measure of prenatal androgen exposure, were found to significantly differ in women with and without dementia. This finding links a relatively feminine in utero development with vulnerability to dementia in women.

Entities: Chemical Disease Gene Species

Keywords: Alzheimer's disease; Dementia; Prenatal androgens; Sex differences; Sexual differentiation

Year: 2020 PMID： 32781308 PMCID： PMC7484057 DOI： 10.1016/j.earlhumdev.2020.105152

Source DB: PubMed Journal: Early Hum Dev ISSN： 0378-3782 Impact factor: 2.079

34 in total

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Authors: M M McCarthy
Journal: J Neuroendocrinol Date: 2010-07 Impact factor: 3.627

Review 2. Why sex matters for neuroscience.

Authors: Larry Cahill
Journal: Nat Rev Neurosci Date: 2006-06 Impact factor: 34.870

Review 3. Through a glass, darkly: Human digit ratios reflect prenatal androgens, imperfectly.

Authors: Ashlyn Swift-Gallant; Brandon A Johnson; Victor Di Rita; S Marc Breedlove
Journal: Horm Behav Date: 2020-02-06 Impact factor: 3.587

Review 4. Sex and the development of Alzheimer's disease.

Authors: Christian J Pike
Journal: J Neurosci Res Date: 2017-01-02 Impact factor: 4.164

Review 5. Sex differences in Alzheimer disease - the gateway to precision medicine.

Authors: Maria Teresa Ferretti; Maria Florencia Iulita; Enrica Cavedo; Patrizia Andrea Chiesa; Annemarie Schumacher Dimech; Antonella Santuccione Chadha; Francesca Baracchi; Hélène Girouard; Sabina Misoch; Ezio Giacobini; Herman Depypere; Harald Hampel
Journal: Nat Rev Neurol Date: 2018-08 Impact factor: 42.937

6. Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.

Authors: Jenna C Carroll; Emily R Rosario; Sara Kreimer; Angela Villamagna; Elisabet Gentzschein; Frank Z Stanczyk; Christian J Pike
Journal: Brain Res Date: 2010-10-08 Impact factor: 3.252

7. Developmental basis of sexually dimorphic digit ratios.

Authors: Zhengui Zheng; Martin J Cohn
Journal: Proc Natl Acad Sci U S A Date: 2011-09-06 Impact factor: 11.205

8. Sex modifies the APOE-related risk of developing Alzheimer disease.

Authors: Andre Altmann; Lu Tian; Victor W Henderson; Michael D Greicius
Journal: Ann Neurol Date: 2014-04-14 Impact factor: 10.422

Review 9. Early Life Epidemiology of Alzheimer's Disease--A Critical Review.

Authors: Alon Seifan; Matthew Schelke; Yaa Obeng-Aduasare; Richard Isaacson
Journal: Neuroepidemiology Date: 2015-10-27 Impact factor: 3.282

10. Low digit ratio (2D:4D) is associated with early natural menopause.

Authors: Sylvia Kirchengast; Elisabeth Dottolo; Elisa Praxmarer; Johannes Huber
Journal: Am J Hum Biol Date: 2019-12-13 Impact factor: 1.937

1 in total

1. Construction of a risk prediction model for Alzheimer's disease in the elderly population.

Authors: Lingling Wang; Ping Li; Ming Hou; Xiumin Zhang; Xiaolin Cao; Hongyan Li
Journal: BMC Neurol Date: 2021-07-07 Impact factor: 2.474

1 in total