Literature DB >> 32014464

Through a glass, darkly: Human digit ratios reflect prenatal androgens, imperfectly.

Ashlyn Swift-Gallant1, Brandon A Johnson2, Victor Di Rita2, S Marc Breedlove3.   

Abstract

On average, the length of the index finger (digit 2) divided by the length of the ring finger (digit 4) on the right hand, is greater in women than in men. Converging evidence makes it clear that prenatal androgens affect the development of digit ratios in humans and so are likely responsible for this sex difference. Thus, differences in 2D:4D between groups within a sex may be due to average differences between those groups in prenatal androgen exposure. There have been many reports that lesbians, on average, have a smaller (more masculine) digit ratio than straight women, which has been confirmed by metaanalysis. These findings indicate that lesbians were, on average, exposed to greater prenatal androgen than straight women, which further indicates that greater levels of prenatal androgen predispose humans to be attracted to women in adulthood. Nevertheless, these results only apply to group differences between straight women and lesbians; digit ratios cannot be used to classify individual women as gay or straight.
Copyright © 2020. Published by Elsevier Inc.

Entities:  

Keywords:  2D:4D; Androgen; Digit ratios; Humans; Lesbians; Organizational hypothesis; Sexual orientation

Year:  2020        PMID: 32014464     DOI: 10.1016/j.yhbeh.2020.104686

Source DB:  PubMed          Journal:  Horm Behav        ISSN: 0018-506X            Impact factor:   3.587


  16 in total

1.  Overexpression of Androgen Receptors Masculinizes 2D:4D Digit Ratios in Mice.

Authors:  Ashlyn Swift-Gallant; Victor Di Rita; Lindsay A Coome; D Ashley Monks
Journal:  Arch Sex Behav       Date:  2021-10-08

2.  Can Digit Ratio (2D:4D) Be Indicative of Predispositions to Autoimmune Thyroid Diseases in Women - Hashimoto Thyroiditis and Graves' Disease?

Authors:  Barbara Święchowicz; Anna Kasielska-Trojan; John T Manning; Bogusław Antoszewski
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-30       Impact factor: 6.055

3.  Second to fourth digit ratio (2D:4D) is associated with dementia in women.

Authors:  Joanne Jiang; Katherine Young; Christian J Pike
Journal:  Early Hum Dev       Date:  2020-08-06       Impact factor: 2.079

4.  Digit Ratio (2D:4D) and Physical Performance in Female Olympic Athletes.

Authors:  Emma Eklund; Lena Ekström; John-Olof Thörngren; Magnus Ericsson; Bo Berglund; Angelica Lindén Hirschberg
Journal:  Front Endocrinol (Lausanne)       Date:  2020-05-12       Impact factor: 5.555

5.  Depression, neuroticism and 2D:4D ratio: evidence from a large, representative sample.

Authors:  Leopold Maria Lautenbacher; Levent Neyse
Journal:  Sci Rep       Date:  2020-07-07       Impact factor: 4.379

6.  No credible evidence for links between 2D:4D and COVID-19 outcomes: A probabilistic perspective on digit ratio, ACE variants, and national case fatalities.

Authors:  Alex L Jones; Bastian Jaeger; Christoph Schild
Journal:  Early Hum Dev       Date:  2020-11-17       Impact factor: 2.079

7.  Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen.

Authors:  Ashlyn Swift-Gallant; Victor Di Rita; Christina A Major; Christopher J Breedlove; Cynthia L Jordan; S Marc Breedlove
Journal:  Sci Rep       Date:  2021-04-14       Impact factor: 4.379

Review 8.  The evolutionary biology of endometriosis.

Authors:  Natalie Dinsdale; Pablo Nepomnaschy; Bernard Crespi
Journal:  Evol Med Public Health       Date:  2021-03-12

9.  Investigating the reliability and sex differences of digit lengths, ratios, and hand measures in infants.

Authors:  Luisa Ernsten; Lisa M Körner; Martin Heil; Gareth Richards; Nora K Schaal
Journal:  Sci Rep       Date:  2021-05-26       Impact factor: 4.379

10.  Masculinized Second-to-Fourth Digit Ratio (2D:4D Ratio) Is Associated With Lower Cortisol Response in Infant Female Rhesus Monkeys (Macaca mulatta).

Authors:  Elizabeth K Wood; Parker Jarman; Elysha Cash; Alexander Baxter; John P Capitanio; J Dee Higley
Journal:  Front Behav Neurosci       Date:  2020-09-03       Impact factor: 3.558

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