| Literature DB >> 20934413 |
Jenna C Carroll1, Emily R Rosario, Sara Kreimer, Angela Villamagna, Elisabet Gentzschein, Frank Z Stanczyk, Christian J Pike.
Abstract
The risk of Alzheimer's disease (AD) is higher in women than in men, a sex difference that likely results from the effects of sex steroid hormones. To investigate this relationship, we first compared progression of β-amyloid (Aβ) pathology in male and female triple transgenic (3xTg-AD) mice. We found that female 3xTg-AD mice exhibit significantly greater Aβ burden and larger behavioral deficits than age-matched males. Next, we evaluated how the organizational effects of sex steroid hormones during postnatal development may affect adult vulnerability to Aβ pathology. We observed that male 3xTg-AD mice demasculinized during early development exhibit significantly increased Aβ accumulation in adulthood. In contrast, female mice defeminized during early development exhibit a more male-like pattern of Aβ pathology in adulthood. Taken together, these results demonstrate significant sex differences in pathology in 3xTg-AD mice and suggest that these differences may be mediated by organizational actions of sex steroid hormones during development.Entities:
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Year: 2010 PMID： 20934413 PMCID： PMC2993873 DOI： 10.1016/j.brainres.2010.10.009
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252