BACKGROUND: Palmar-plantar erythrodysesthesia (PPE) is a common adverse event seen with many chemotherapeutic agents as well as targeted therapies which is very debilitating for the patient. To the best of our knowledge there are only a few cases of PPE reported with methotrexate infusion to date. CASE AND CONCLUSION: We report a case of Burkitt Lymphoma, who developed severe PPE with methotrexate infusion and responded very well with conservative management and dose reduction in subsequent cycles.
BACKGROUND:Palmar-plantar erythrodysesthesia (PPE) is a common adverse event seen with many chemotherapeutic agents as well as targeted therapies which is very debilitating for the patient. To the best of our knowledge there are only a few cases of PPE reported with methotrexate infusion to date. CASE AND CONCLUSION: We report a case of Burkitt Lymphoma, who developed severe PPE with methotrexate infusion and responded very well with conservative management and dose reduction in subsequent cycles.
Authors: Seth E Karol; Wenjian Yang; Colton Smith; Cheng Cheng; Clinton F Stewart; Sharyn D Baker; John T Sandlund; Jeffrey E Rubnitz; Michael W Bishop; Alberto S Pappo; Sima Jeha; Ching-Hon Pui; Mary V Relling Journal: Cancer Date: 2017-05-11 Impact factor: 6.860
Authors: L Hueso; O Sanmartín; E Nagore; R Botella-Estrada; C Requena; B Llombart; C Serra-Guillén; A Alfaro-Rubio; C Guillén Journal: Actas Dermosifiliogr Date: 2008-05