Evaluation of Fear in Idiopathic Epilepsy Using Population-Based Survey and Bhalla-Gharagozli Fear in Epilepsy Questionnaire (BG-FEQ).

INTRODUCTION: The primary objective of this study was to evaluate fear related to epilepsy and its treatment among those with idiopathic epilepsy. Our secondary objective was to estimate the psychometric properties of a brief Bhalla-Gharagozli Fear in epilepsy Questionnaire (BG-FEQ).
METHODS: We conducted patient-finding exercise in our study areas through various means to obtain subjects with idiopathic epilepsy. We carefully examined each patient through a detailed case-history examination. Following that, we evaluated fear related to epilepsy by using Bhalla-Gharagozli Fear in Epilepsy Questionnaire (BG-FEQ) across two broad domains: epilepsy and pharmacotherapy.
RESULTS: The study obtained 52 subjects (39.0 years; 45.0% males, 70.0% married, 35.0% unqualified, 85.0% active epilepsy, 80.0% generalized seizures) with idiopathic epilepsy. The alpha coefficient was 92.8, with no item-specific coefficient of ≤0.91. The alpha coefficient was 0.90 and 0.93 for reporting a "yes" and "no" to the items, respectively. We obtained a two-factor structure of BG-FEQ that provided a cumulative variance of 83.6%. The majority (65.0%) reported at least one fear. The per-patient mean number of the fear element was 2.1 (95% CI 1.1-3.3), which differed significantly for males and females (1.1, 95% CI 0.4-2.6 and 3.0, 95% CI 1.4-4.6, respectively, p=0.03). The most frequent fear was that of addiction and the bad effects of anti-seizure medications (both 45.0%). Upon bootstrap regression after constraining gender, the fear elements were associated with illiteracy, difficulty in understanding epilepsy and sleeping in a prone position. The sample power was 99.0%.
CONCLUSION: There was a significant representation of fear among those with idiopathic epilepsy, especially among the females, particularly the fear of brain tumour, premature death and more frequent/severe seizures over time. At least 65.0% of idiopathic subjects are likely to be affected by at least one fear. The essential mitigating approach should be the education of practitioners towards better identification and therapeutic handling of comorbid constructs, and also for the education of patients and their caregivers towards better awareness and prevention. There is also a need for formal Epilepsy Educators towards better awareness, therapeutic support and prevention of epilepsy.

Introduction

Those with epilepsy are “more than their mere illness”. By this, we mean that satisfactory therapeutic outcome and social and physical wellbeing of those with epilepsy also depend upon timely identification and mitigation of comorbid cognitive, behavioural, emotional or psychosocial issues that inadvertently arise due to epilepsy.1 One such issue is the element of fear related to epilepsy or its treatment. Fear is an important parameter to assess in general, and it has both positive and negative connotations. For instance, the perceived fear of untoward consequences from the illness may lead patients to espouse health-promoting actions. But, on the other hand, the perceived fear of adverse effect from medications may keep patients away from up taking them adequately, etc.2 Overall, fear has an association with medication compliance, parasuicidal behaviour, aggression, lower quality of life, tenuous relationships with peers, poor education and low income.3,4

In epilepsy, fear is one of the forgotten comorbid psychopathological constructs that is rarely recognized. However, it is seen that epilepsy patients commonly fear death and brain damage resulting from their seizures.3 Among those with epilepsy, the elements of fear may arise due to many reasons. For instance, the unpredictable and sudden onset nature of seizures may lead to anxious anticipation or distress of the consequences from a feared situation (ie, epilepsy), which may, in turn, interfere with one’s physical, mental and social functioning. Since epilepsy is a chronic ailment and requires uptake of treatment over a long period, the fear may also arise due to the pervasive effects of epilepsy as a long-term illness. Some epilepsy patients are seen to develop an actual phobic anxiety state relating to their seizures.4 Fear is also important in the diagnosis of epilepsy because the patients could be considered as having panic attacks, which may delay the diagnosis of epilepsy.5 Apart from the brief mention, fear in epilepsy does not appear much in the literature.4

Thus, with such a vision, the primary objective of our study was to estimate fear related to epilepsy and identify its sociodemographic and clinical correlates among those with idiopathic epilepsy. Our secondary objective was to measure the psychometric parameters of a brief fear in epilepsy questionnaire. We consider that our work would provide a reason to seek better identification of comorbid psychopathologies, which, in turn, may support mental health, therapeutic optimization and outcomes among affected epilepsy subjects.

Methods

We identified all adult subjects (15+ years of age) of both gender with idiopathic epilepsy,6 who were interested in participating, were resident (for at least six months), otherwise able and belonged to any of the 26 health house areas of Demavend. Throughout the villages of the entire country, health houses maintain a structured household file for every household that comes under their jurisdiction to record every health-related event through regular and continuous contact with their concerned population. This kind of patient identification remains continuous.

The health houses are run by trained local employees, who are attached to concerned district hospitals. As additional patient-finding measures, we implemented supplementary verbal information campaigns through health houses for those who may be interested in taking cost-free convenient consultation at home by city specialists. We also made additional inquiries from the village residents and fellow patients upon domestic health visits.7–9

All patients were re-examined and re-diagnosed with the help of a structured and detailed case-history examination. This examination included capturing details on sociodemographic aspects, past medical history, the natural history of epilepsy and seizures, risk factor exposure, precipitating factors, clinical examination, electroencephalogram (EEG) and CT/MRI results, and treatment aspects (both traditional and modern). The criterion for the diagnosis of epilepsy was a clear description of the recurrent and paroxysmal time-limited change in motor activity or behaviour. The inclusion did not have acute symptomatic seizures (ie, a clinical seizure with a close temporal association with a documented brain or systemic insult), febrile seizures (ie, seizures occurring in association with febrile illness), or a single isolated seizure. As per convention, EEG was not the basis for diagnosing epilepsy. The consciousness was the main discriminator. We categorized seizures based on “best fit” seizure classification from the information that we collected from each subject.10

Also, we categorized our patients based on the etiological type as idiopathic. These are the ones for whom no conventional underlying etiological factor was confirmed or suspected to be present, either currently or in the past. Those with symptomatic and cryptogenic epilepsies were discarded and not processed further.

We evaluated fear related to epilepsy by using Bhalla-Gharagozli Fear in epilepsy Questionnaire (BG-FEQ). We structured our questionnaire under two broad components related to plausible representation and perception of the consequences of epilepsy and anti-seizure medications (ASMs). These included the fear of (a) brain tumour, (b) premature death, (c) more frequent/severe seizures over time, (d) suffocation during seizure attacks, (e) addiction with ASMs, (f) adverse effects with long-term use of ASMs. Upon a review of possible literature2–5 and hands-on experience with epilepsy, we prepared a pool of items that possibly represent fear. After that, a series of discussions took place, and we selected those items that were deemed to be most relevant in describing the perceptions of fear in epilepsy while respecting the requirement in terms of relevance, brevity, feasibility, readability, consistency of style and formatting, and clarity of the language. An expert panel comprising of specialists from neurology, mental health, and public health evaluated content validity. We used the responses from this panel to improve the items. The content validity index (CVI) was measured, and a CVI score higher than 0.75 was considered acceptable.11 The responses to each of the six epilepsy-related elements of fear were dichotomous based on the patient’s subjective perception about the absence (score zero) or presence (score one) of those elements. Each patient’s fear score was the sum of the total number of fear elements that were reportedly present among them, which were then averaged for the entire sample population as well as for the males and females.

All data were systematically analyzed. Wherever required, the data were summarized descriptively in terms of mean, number, frequency, proportion, 95% confidence interval (CI). We determined the psychometric properties of our questionnaire by measuring the alpha coefficient for all items together and for individual items. Those items that had a low (<0.3) item-test correlation were deleted. Alpha coefficient was also measured group-wise, ie, separately for yes or no to an item. We did exploratory factor analysis (EFA) to determine the possible number of latent factors that items altogether could be categorized into, by using eigenvalue ≥1.0 and factor loadings ≥0.40. We used the scree plot for EFA. For confirmatory factor analysis (CFA), we estimated fit indices, size of residual, and coefficient of determination.

After that, by using logistic regression, we determined the association of individual fear elements with all possible independent variables separately, after constraining the effects of gender. Later, the bootstrap method was used with 100x replication of our sample to determine the odds ratio. In a posthoc manner, we estimated the required sample size and power by using the mean fear obtained as against the ideal situation of no fear. The sample power was estimated after accounting for an alpha of 0.05, a standard deviation of 3.0, sample size, and the mean number of fear elements obtained. Lastly, we received informed consent from all subjects before permitting their participation. We obtained ethics approval from the Institutional Review Board of Shahid Beheshti University of Medical Sciences. This study was conducted in accordance with the Declaration of Helsinki.

Results

We recruited a total of 52 subjects with idiopathic epilepsy. The clinical and sociodemographic description is as follows: median age (39.0, 95% CI 33.3–44.7), 45.0% males, 70.0% married and 35.0% illiterate. The average frequency and duration (onset to recovery) of seizures in the last 30 days were 1.5 seizures (95% CI 0.7–2.3) and 0.9 (95% CI 0.2–1.7) minutes, respectively. Active epilepsy was present in 85.0% of subjects, 80.0% had generalized seizures (68.7% tonic-clonic, 25.0% myoclonic, 6.2% absence), 65.0% had an EEG, of which only 25.0% had abnormal EEG findings including generalized spike-wave complex and polyspikes, and focal slowing with or without spikes. Eighty percent of subjects had a CT/MRI scan, of which none had a structural lesion or any other abnormality.

Psychometric Properties

The alpha coefficient was estimated to be 92.8, while none of the items had this coefficient lesser than 0.91. For individual items, the item-test correlation was no less than 0.79. By group, the alpha coefficient was 0.90 and 0.93 for those reporting a yes and those reporting a no to the questionnaire items, respectively. Upon EFA, we found a two-factor structure for our questionnaire with a cumulative variance of 83.6%, Figure 1. The KMO for sampling adequacy was 0.80. Upon CFA, we found a 97.0% coefficient of determination, 0.80 fit indices, and a small (0.05) standardized residual. In a posthoc measure, we estimated the required sample size and power for the mean fear of 2.1 as against the ideal situation of no fear, and the required sample was 22. The power of our sample was 99.0% at an alpha of 0.05, a standard deviation of 3.0, a sample size of 52, and a mean number of fear elements of 2.1.

Figure 1

A scree plot that shows a two-factor latent structure of the Bhalla-Gharagozli Fear in Epilepsy Questionnaire (BG-FEQ) regarding fear related to epilepsy and anti-seizure medications.

Fear Assessment

The majority (65.0%) of subjects reported having at least one fear element. The mean per-patient number of fear elements for the overall population was 2.1 (95% CI 1.1–3.3, range 0–6), which, by gender, was 1.1, 95% CI 0.39–2.6 and 3.0, 95% CI 1.4–4.6, respectively, p=0.03 for the males and females, respectively. Among the entire sample population, the most common fear present was the fear of addiction and adverse effects of ASMs over the long term, which was reported by 45.0% subjects, each. Other fear elements were the fear of having more frequent/severe seizures over time (35.0%), fear of brain tumour (35.0%), fear of premature death (30.0%), and the fear of suffocation during seizure attack (25.0%).

We found that the mean grade of individual fear elements differed between males and females over a scale of zero to one. These elements were the: fear of: brain tumour (0.1, 95% CI 0.01–0.4 and 0.5, 95% CI 0.2–0.9, p=0.02), premature death (0.1, 95% CI 0.01–0.4 and 0.4, 95% CI 0.1–0.8, p=0.05), and more frequent/severe seizures over time (0.1, 95% CI 0.01–0.4 and 0.5, 95% CI 0.2–0.9, p=0.02). There was no such gender difference regarding the fear of suffocation, fear of addiction or the fear of adverse effects with the use of ASMs, Table 1. Upon logistic regression after constraining the impact of gender and bootstrapping of our sample the 100 times, the fear elements were associated with several factors, Table 2.

Table 1

The Representation of Fear in Idiopathic Epilepsy

Parameter	Result
Mean per-patient number of fear elements present (overall)	2.1 (1.1–3.3), range 0–6
Mean per-patient number of fear elements (by gender, p value from group comparison)	Males: 1.1 (0.4–2.6), range 0–6 Females: 3.0 (1.4–4.6), range 0–6, p=0.03, Effect size (r): 0.4
Frequency of fear elements (overall population)	Fear of addiction: 45.0%, Bad effects over the long term: 45.0% Fear of having more frequent/severe seizures over time: 35.0%, Fear of brain tumor: 35.0%, Fear of premature death: 30.0%, and Fear of suffocation during seizure attack: 25.0%
Mean grade by which fear elements are present (overall population)	Fear of suffocation during seizure attack: 0.8 (0.5–0.9)a, range 0–1 Fear of premature death: 0.7 (0.5–0.8)a, range 0–1 Fear of brain tumor: 0.6 (0.4–0.8)a, range 0–1 Fear of more frequent/severe seizures over time: 0.6 (0.4–0.8)a, range 0–1 Fear of addiction: 0.4 (0.2–0.7)a, range 0–1 Fear of bad effects over the long term: 0.4 (0.2–0.7)a, range 0–1
Gender-wise comparison of mean grade by which the fear elements are present (fear type, males, females, score range and p value, respectively)	Brain tumor	0.1 (0.01–0.4)a	0.5 (0.2–0.9)a	Range 0–1, p=0.02
	Premature death	0.1 (0.01–0.4)a	0.4 (0.1–0.8)a	Range 0–1, p=0.05
	More frequent/severe seizures over time	0.1 (0.01–0.4)a	0.5 (0.2–0.9)a	Range 0–1, p=0.02
No gender difference (ie p>0.05) in the mean grade by which fear elements are present	Suffocation during seizure attacks, Fear of addiction, and Bad effects over long-term use of ASMs
Group comparison of those with and without fear element	Risk of injury/accident: 14.0 (1.2–26.8)a, p=0.03 Difficulty in understanding why seizures start and stop: 9.6 (1.9–17.3)a, p=0.03

Note: aRange in the bracket refers to 95% confidence interval.

Table 2

The Representation of Fear and Their Association with Sociodemographic Parameters in Idiopathic Epilepsy

Fear Representation, Fear of ….	Independent Variable	100x Bootstrapped Odds Ratio (95% CI), p-Value
Premature death	Difficulty in understanding the nature of epilepsy	26.0, 95% CIa 3.3–48.7, p=0.002
Suffocation during seizure attacks	Illiteracy	16.0, 95% CIa 3.1–28.9, p=0.001
	Sleep in prone position	35.0, 95% CIa 6.9–63.1, p=0.001
	Generalized seizures	20.0, 95% CIa 3.6–36.4, p=0.001
	Last seizure ≥5 minutes	9.3, 95% CIa 1.3–17.3, p=0.02

Abbreviation: aCI, confidence interval.

Discussion

It was necessary to conduct this study for many reasons. For instance, the lay beliefs about epilepsy may help to understand the patient’s cognitive or emotional response to their illness,12 which may pave a way to influence their coping strategies and in turn their therapeutic outcomes.13 As an example, many subjects with epilepsy never achieve clinical remission despite numerous therapeutic options,14 due to which, their routine life continues to remain affected. So, focusing on the patient’s comorbid psychopathological constructs may provide treating physicians the ways to deliver results beyond mere symptomatic control, which may, in turn, normalize patient’s lives.15

Moreover, there are reasonable reasons for enquiring about the elements of fear among those with epilepsy because, unlike many other chronic diseases, the onset of symptoms (ie, seizures) in epilepsy is sudden and unexpected. This sudden onset is against, for instance, the theory of locus of control, which is closely linked to the risk of poor psychopathological states.16 Likewise, we included only those with idiopathic epilepsy as they are unique in the sense that, by definition, the underlying cause of their epilepsy is not known,6 which goes against the theory of causal inference. For example, the fear elements were related to the difficulty in understanding the nature of epilepsy and why do seizures start and stop (Table 2).

The methods of our study were adequately robust. For instance, we derived our sample from the general population, and the participants were resident and of both genders. Thus, we did not have selective patients that are otherwise possible with other study designs. We used the bootstrap method with 100 times replication, which means that we derived our results after replicating the application of our sample 100 times. We provided our results in terms of effect size, which does not depend upon the sample size, unlike other measures of association. Our sample had high statistical power.17 Furthermore, our questionnaire relates well to many common representations of fear that patients may have about their epilepsy or its treatment. For instance, the fear of death or brain damage3 or poor general perception about the safety of ASMs.2 Our questionnaire also relates well to many theoretical frameworks, such as the appraisal theory of emotion or cognitive-mediational theory. These theories assert that our emotions (ie, fear) are determined by our appraisal of the fear stimulus (ie, epilepsy or its treatment).

We performed a psychometric assessment of our questionnaire; a tool that was not available earlier for assessing the elements of fear in epilepsy and for those from a non-westernized context. A lack of valid intervening tools is one of the reasons for many critical comorbidities to remain undetected on time,18 even though effective solutions are available for mitigating them in epilepsy.15 The alpha coefficient of internal consistency was considerably higher than the usual criteria of 0.70. The high alpha coefficient means that all our elements were in line with each other to measure a common underlying construct. Also, our questionnaire was not biased to raise one particular type of participant response since the group alpha coefficient for responding a yes to an item (α0.90), and no to an item (α0.93) was sufficiently high and similar to each other. Besides these, our factor structure was also adequate, for instance, 97.0% coefficient of determination, 83.6% cumulative variance, and 0.05 as the standardized residual. For factor analyses, we used conventional parameters, such as eigenvalue ≥1.0 and factor loading ≥0.40. Moreover, the anticipated two-factor structure (ie, fear related to epilepsy and fear related to epilepsy treatment) of our questionnaire also got confirmed.

The majority (65.0%) of our subjects reported having at least one element of fear. Those who did not report any element of fear may have undergone a cognitive process of conditioning. For example, accepting therapeutic value from the uptake of ASMs could be a way people with epilepsy attempt to cure/control their negative emotions [10]. The most frequent fear was related to addiction and untoward effect from the prolonged use of ASMs, Table 1. Fear about ASMs is not unfounded since ASMs are widely perceived as unfavourable among all, be it the physicians,19,20 health system actors,21 or the patients.2 This unfortunate impression of ASMs is there, even though the safety of ASMs has never been adequately and appropriately assessed.22–24 So, from these results, we may infer the need for treating physicians to discuss upfront such gaps in the knowledge that we currently have regarding the safety profile of ASMs. If done, such discussions may help patients overcome their apprehension or fear about ASMs, and possibly, to have improved adherence and therapeutic outcomes.15 Similarly, from these results, we may also infer yet another reason for the imminent need to adequately assess the safety of ASMs to help have conclusive evidence about the potential risks of using ASMs for epilepsy in different populations.22–24

Further, we found that females had a 92.6% higher per-patient mean number of fear elements than males, p=0.03, particularly the fear of brain tumour, premature death and more frequent or severe seizures over time, Table 2. There can be many possible reasons for this gender difference. For instance, the difference in neurotic personality trait between males and females25 and the difference in how the process of fear is perceived by them.26 So, we may infer that the assessment of personality trait, especially among female epilepsy subjects, could usefully become a part of regular epilepsy care. The evaluation of personality is meaningful since one’s personality type can be modified with therapy,27 which may, in turn, help to improve one’s attitude and practice regarding day-to-day self-management of epilepsy.28 A neurotic trait is one of the most studied traits, and its relation to medication compliance is not unexpected.29 Another reason we anticipate for the gender difference in fear could be related to the fact that idiopathic epilepsies are more frequent among females, something we observed as well since 55.0% of our subjects were female.

We also identified factors that were associated with different elements of fear. For instance, the fear of premature death was related to the difficulty in understanding the nature of epilepsy, and, similarly, illiteracy was associated with the fear of suffocation during seizure attack, Table 2. Literacy is an apparent protective factor because it exposes the patients to different channels of information, which may help to reduce one’s negative emotional perception about their illness.30 Although literacy is not a factor that can be modified at the patient level, others have shown that health literacy31 instead may translate into less harmful psychological elements.30 For instance, in our study, the fear of premature death was related to the difficulty in understanding the nature of epilepsy. Moreover, those with and without fear differed in terms of difficulty in understanding why seizures start and stop, Table 2.

There are plenty of valid ways by which the patient’s (or their caregivers) health literacy, and therefore, their apprehension and misrepresentation on epilepsy could be improved, for instance, through domestic health visiting.7–9 This multi-purpose approach of domestic health visiting provides home-based convenient services of treatment, follow-up and consistent and repeated message delivery through local intermediaries. The other ways to improve health literacy among the patients are educational interventions that can improve the patient’s coping skills and their social and physical wellbeing.15 Also, information exchange by treating physicians with their patients (or caregivers) is also critical to improve health literacy, but, something that is rarely done,32 even though there are obvious benefits of doing that.33,34 For instance, my sister was hospitalized and was to be operated. I was worried and asked her physician many questions. He said why do you ask so many questions? I said I wanted to know about her disease. He said he did not have time to spend an hour to answer my silly questions.35 Others have also shown that medical staff is usually unaware of patients’ ideas about their condition.36 Another way by which health literacy needs and mitigation of negative apprehension of the patients about their illness could be addressed is by setting up entirely novel system of Epilepsy Educators. As an example, there are about 20,000 unemployed nurses in Iran.37 Such unemployed health personnel, ex-patients, or general unemployed youths could be trained as Epilepsy Educators for providing their services at home, in the local community, or at dedicated epilepsy care institutions.

Another set of factors that were associated with the elements of fear, particularly the fear of suffocation during seizure attack, were often sleeping in a prone position or when seizures are intense, long-lasting, and generalized.33 These are also the patient characteristics that are more likely to die suddenly and unexpectedly,33 which shows that different fear elements may not have isolated origins. One example that supports this premise is that for the majority of subjects with epilepsy who die unexpectedly, the immediate event before death would be the difficulty in breathing.33 So, based on these results, we may infer that patient’s apprehensions could be mitigated by providing them with distinctive characteristics (such as those just above) to, in turn, help them distinguish better their risk for untoward consequences from epilepsy. For instance, there is a risk of unexpected premature death among those with epilepsy, but that risk is pretty low.33 Similarly, the long-term use of ASMs may render a fear of addiction and adverse effects, Table 1. Still, existing data does not indicate any considerable change in the craving for ASMs.22 So, it all comes down to providing the patients (or their caregivers) with right, specific, timely and adequate information based on particular features of their illness.

Our work brings forth new information; for instance, the systematic assessment of fear in epilepsy hardly appears in the literature4 even though epilepsy patients commonly fear death and brain damage from their seizures.3 Assessing fear in itself is indispensable because the fear may diminish the quality of life, may cause panic, anxiety or phobic disorders, or may even be a deterrent to effective self-management and psychological wellbeing of the patients.4 In addition, our study provides a brief, validated instrument for assessing fear, which was not currently available as far as we are aware of. The absence of such intervention tools is one of the reasons that many critical comorbidities may remain undetected,18 which is unfortunate since those can otherwise be effectively mitigated through psychotherapies.15 Thus, we expect that timely detection and appropriate management of comorbid psychopathological constructs like fear may not only shorten the duration of suffering for those with epilepsy but may also improve their quality of life and social impairment in the long term.38 Others have also shown that targeting epilepsy patient’s perceptions and misrepresentation may help to reduce their anxiety and help them adjust to their illness.15

The application of our study also remains for those of the many epilepsy patients who never achieve clinical remission despite several pharmacotherapeutic options.14 Furthermore, our work calls treating physicians to discuss adequately upfront with the patients from early-on the distinctive characteristics of epilepsy. Our work also calls to consider personality assessment and default psychotherapy among female subjects as part of their usual epilepsy care.39 Our work also proposes the entirely new concept of Epilepsy Educators which may open professional avenues for unemployed professionals, youths and ex-patients.

We estimated the power of our sample by using sample size and standard deviation as the input,17 and we found that our sample power to be adequately high. Lastly, as usual, our work has a few limitations. For instance, there are other possible variables that we did not assess for this work, such as the neurotic trait, etc., that may otherwise help in better understanding of the patient’s fear related to their illness. Similarly, our questionnaire had a few elements of fear, and there can be a few other elements, depending upon the cultural context of the patients and opinion of the intervening practitioners. As is the situation with other published studies, our work is also based on self-reports.

Moreover, our study did not have a control group that may have helped to compare the results. All subjects were assessed during a clinical interview for possible psychiatric disturbances, as it is done in a usual clinical set-up. However, we did not use a separate detailed instrument for that to avoid the burden on the participants and possible loss of their participation.

Conclusions

There was a significant element of fear related to epilepsy and its treatment among our patients, especially among the females, particularly the fear of brain tumour, premature death, and more frequent/severe seizures over time. The gender difference appears to be a sheer biological distinction between males and females on how they perceive and process fear emotion. If our work can do nothing else, at least it can become a reason to call for the additional education of practitioners towards active identification and therapeutic handling of comorbid psychopathological constructs in epilepsy. There is also a need to call for adequate education of patients and their caregivers about the very specific and distinctive characteristics of epilepsy and its treatment, which may help to reduce their undue apprehensions. There is also a need for establishing formal Epilepsy Educators to achieve better awareness, therapeutic support and prevention of epilepsy. Lastly, we think that suitable female subjects with epilepsy would benefit from epilepsy care integrated with a psychotherapy.