Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 [Pharmacotherapy of alcohol withdrawal: update and new developments].

Literature DB >> 32696076

[Pharmacotherapy of alcohol withdrawal: update and new developments].

Abstract

So far few medications are approved for prophylactic treatment of alcohol dependence relapse. Apart from disulfiram, which is no longer marketed in Germany, the opioid antagonists naltrexone, nalmefene and the putative glutamate antagonist acamprosate are approved. In some other countries, baclofen and gamma-hydroxybutyrate (GHB) are licensed. Possible other drugs of interest for prophylaxis of alcohol dependence relapse are vareniclin, gabapentin, and topiramate, but so far none of them have received approval. In the light of the currently running revision of the German guidelines for the diagnosis and treatment of alcohol related disorders, an update on the pharmacotherapy of alcohol dependence is presented.

Entities: Chemical Disease Gene Mutation Species

Keywords: Acamprosate; Alcohol use disorders; Anti-Craving-Drugs; Naltrexone; Relapse

Mesh：

Substances：

Year: 2021 PMID： 32696076 DOI： 10.1007/s00115-020-00954-5

Source DB: PubMed Journal: Nervenarzt ISSN： 0028-2804 Impact factor: 1.214

85 in total

1. Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial.

Authors: Giovanni Addolorato; Lorenzo Leggio; Anna Ferrulli; Silvia Cardone; Giorgio Bedogni; Fabio Caputo; Giovanni Gasbarrini; Raffaele Landolfi
Journal: Alcohol Alcohol Date: 2011-03-17 Impact factor: 2.826

2. Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial.

Authors: Esther M Beraha; Elske Salemink; Anna E Goudriaan; Abraham Bakker; David de Jong; Natasha Smits; Jan Willem Zwart; Dick van Geest; Pieter Bodewits; Tom Schiphof; Harma Defourny; Mirjam van Tricht; Wim van den Brink; Reinout W Wiers
Journal: Eur Neuropsychopharmacol Date: 2016-11-11 Impact factor: 4.600

3. Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician.

Authors: Olivier Ameisen
Journal: Alcohol Alcohol Date: 2004-12-13 Impact factor: 2.826

4. A meta-analysis of topiramate's effects for individuals with alcohol use disorders.

Authors: Janet C Blodgett; A C Del Re; Natalya C Maisel; John W Finney
Journal: Alcohol Clin Exp Res Date: 2014-05-05 Impact factor: 3.455

5. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.

Authors: Raymond F Anton; Stephanie S O'Malley; Domenic A Ciraulo; Ron A Cisler; David Couper; Dennis M Donovan; David R Gastfriend; James D Hosking; Bankole A Johnson; Joseph S LoCastro; Richard Longabaugh; Barbara J Mason; Margaret E Mattson; William R Miller; Helen M Pettinati; Carrie L Randall; Robert Swift; Roger D Weiss; Lauren D Williams; Allen Zweben
Journal: JAMA Date: 2006-05-03 Impact factor: 56.272

6. Measuring outcome in interventions for alcohol dependence and problem drinking: executive summary of a conference sponsored by the national institute on alcohol abuse and alcoholism.

Authors: John P Allen
Journal: Alcohol Clin Exp Res Date: 2003-10 Impact factor: 3.455

7. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study.

Authors: Giovanni Addolorato; Lorenzo Leggio; Anna Ferrulli; Silvia Cardone; Luisa Vonghia; Antonio Mirijello; Ludovico Abenavoli; Cristina D'Angelo; Fabio Caputo; Antonella Zambon; Paul S Haber; Giovanni Gasbarrini
Journal: Lancet Date: 2007-12-08 Impact factor: 79.321

[Pharmacotherapy of alcohol withdrawal: update and new developments].

1. Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial.

2. Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial.

3. Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician.

4. A meta-analysis of topiramate's effects for individuals with alcohol use disorders.

5. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.

6. Measuring outcome in interventions for alcohol dependence and problem drinking: executive summary of a conference sponsored by the national institute on alcohol abuse and alcoholism.

7. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study.

Review 8. Serotonergic gene variation in substance use pharmacotherapy: a systematic review.

9. Effectiveness of Gabapentin in Reducing Cravings and Withdrawal in Alcohol Use Disorder: A Meta-Analytic Review.

Review 10. Antidepressants for the treatment of people with co-occurring depression and alcohol dependence.

Review 1. [Acceptance and use of web-based interventions for alcohol abstinence].