Literature DB >> 32695639

Use of cardiac magnetic resonance to detect changes in metabolism in heart failure.

William D Watson1, Jack J J Miller1,2,3, Andrew Lewis1, Stefan Neubauer1, Damian Tyler1,2, Oliver J Rider1, Ladislav Valkovič1,4.   

Abstract

The heart has a massive adenosine triphosphate (ATP) requirement, produced from the oxidation of metabolic substrates such as fat and glucose. Magnetic resonance spectroscopy offers a unique opportunity to probe this biochemistry: 31Phosphorus spectroscopy can demonstrate the production of ATP and quantify levels of the transport molecule phosphocreatine while 13Carbon spectroscopy can demonstrate the metabolic fates of glucose in real time. These techniques allow the metabolic deficits in heart failure to be interrogated and can be a potential future clinical tool. 2020 Cardiovascular Diagnosis and Therapy. All rights reserved.

Entities:  

Keywords:  Metabolism; cardiomyopathy; heart failure; magnetic resonance

Year:  2020        PMID： 32695639      PMCID： PMC7369287          DOI： 10.21037/cdt.2019.12.13

Source DB:  PubMed          Journal:  Cardiovasc Diagn Ther        ISSN： 2223-3652


  98 in total

1.  Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts.

Authors:  Glenn A Hirsch; Paul A Bottomley; Gary Gerstenblith; Robert G Weiss
Journal:  J Am Coll Cardiol       Date:  2012-02-28       Impact factor: 24.094

2.  Human myocardial ATP content and in vivo contractile function.

Authors:  R C Starling; D F Hammer; R A Altschuld
Journal:  Mol Cell Biochem       Date:  1998-03       Impact factor: 3.396

Review 3.  MR spectroscopy of the human heart: the status and the challenges.

Authors:  P A Bottomley
Journal:  Radiology       Date:  1994-06       Impact factor: 11.105

4.  Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study.

Authors:  Ronald Ouwerkerk; Paul A Bottomley; Meiyappan Solaiyappan; Amy E Spooner; Gordon F Tomaselli; Katherine C Wu; Robert G Weiss
Journal:  Radiology       Date:  2008-07       Impact factor: 11.105

5.  The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function.

Authors:  Rutger W van der Meer; Luuk J Rijzewijk; Michaela Diamant; Sebastiaan Hammer; Michael Schär; Jeroen J Bax; Johannes W A Smit; Johannes A Romijn; Albert de Roos; Hildo J Lamb
Journal:  Eur Heart J       Date:  2008-05-19       Impact factor: 29.983

6.  Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus.

Authors:  Luuk J Rijzewijk; Rutger W van der Meer; Johannes W A Smit; Michaela Diamant; Jeroen J Bax; Sebastiaan Hammer; Johannes A Romijn; Albert de Roos; Hildo J Lamb
Journal:  J Am Coll Cardiol       Date:  2008-11-25       Impact factor: 24.094

7.  In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy.

Authors:  Anne-Marie L Seymour; Lucia Giles; Vicky Ball; Jack J Miller; Kieran Clarke; Carolyn A Carr; Damian J Tyler
Journal:  Cardiovasc Res       Date:  2015-03-05       Impact factor: 10.787

8.  OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB.

Authors:  Lucian A B Purvis; William T Clarke; Luca Biasiolli; Ladislav Valkovič; Matthew D Robson; Christopher T Rodgers
Journal:  PLoS One       Date:  2017-09-22       Impact factor: 3.240

9.  Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.

Authors:  Marie A Schroeder; Angus Z Lau; Albert P Chen; Yiping Gu; Jeevan Nagendran; Jennifer Barry; Xudong Hu; Jason R B Dyck; Damian J Tyler; Kieran Clarke; Kim A Connelly; Graham A Wright; Charles H Cunningham
Journal:  Eur J Heart Fail       Date:  2012-12-19       Impact factor: 15.534

10.  Hyperpolarized ketone body metabolism in the rat heart.

Authors:  Jack J Miller; Daniel R Ball; Angus Z Lau; Damian J Tyler
Journal:  NMR Biomed       Date:  2018-04-10       Impact factor: 4.044
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  3 in total

1.  Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility.

Authors:  Matthew K Burrage; Andrew J Lewis; Jack J J Miller
Journal:  Cardiovasc Drugs Ther       Date:  2022-07-26       Impact factor: 3.947

2.  Increased cardiac Pi/PCr in the diabetic heart observed using phosphorus magnetic resonance spectroscopy at 7T.

Authors:  Ladislav Valkovič; Andrew Apps; Jane Ellis; Stefan Neubauer; Damian J Tyler; Albrecht Ingo Schmid; Oliver J Rider; Christopher T Rodgers
Journal:  PLoS One       Date:  2022-06-16       Impact factor: 3.752

Review 3.  In Vivo Magnetic Resonance Spectroscopy Methods for Investigating Cardiac Metabolism.

Authors:  Morteza Esmaeili; Riyas Vettukattil
Journal:  Metabolites       Date:  2022-02-18
  3 in total

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