Li Li1,2, Yang Liu2, Xinxin Li2, Chunguang Qiu1. 1. Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. 2. Department of Emergency Internal Medicine, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, China.
Abstract
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. High mobility group box 1 (HMGB1) has been demonstrated to be involved in AF, but the genetic relationship between them is not clear yet. Here, we investigated the genetic association between functional variants in HMGB1 and AF in a Chinese Han population. METHODS: Two common variants (the promoter one rs1045411T/C and the 3'UTR one rs1412125C/T) in HMGB1 were selected and genotyped in 576 AF patients and 869 control subjects. Traditional risk factors, such as age, gender, the history of smoking, hypertension and diabetes mellitus, were adjusted as covariates using a logistic regression analysis (SPSS, v.21.0). The haplotypic analysis was performed using SPSS (v.21.0, Inc., Chicago, IL, USA). RESULTS: Under the allelic association analysis, neither rs1045411T/C nor rs1412125C/T was associated with AF with all P values >0.05; under the genotypic association analysis, the 3'UTR variant rs1045411T showed a marginally significant association with AF under the recessive model (Padj=0.056, OR =0.42; 95% CI: 0.17-1.02). When divided the studied population by gender, we still found no significant association results between the selected variants and AF with P values more than 0.05; however, when divided the population into subgroups by the age onset of AF, we found that the 3'UTR variant rs1045411T was significantly associated with AF in the late-onset subgroup (Padj=0.009, OR =11.1; 95% CI: 1.82-50.0). CONCLUSIONS: The 3'UTR variant rs1045411T/C of HMGB1 might influence the risk of late-onset AF in the Chinese Han population, which provides an important target factor for the prevention and treatment study of AF. 2020 Cardiovascular Diagnosis and Therapy. All rights reserved.
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. High mobility group box 1 (HMGB1) has been demonstrated to be involved in AF, but the genetic relationship between them is not clear yet. Here, we investigated the genetic association between functional variants in HMGB1 and AF in a Chinese Han population. METHODS: Two common variants (the promoter one rs1045411T/C and the 3'UTR one rs1412125C/T) in HMGB1 were selected and genotyped in 576 AF patients and 869 control subjects. Traditional risk factors, such as age, gender, the history of smoking, hypertension and diabetes mellitus, were adjusted as covariates using a logistic regression analysis (SPSS, v.21.0). The haplotypic analysis was performed using SPSS (v.21.0, Inc., Chicago, IL, USA). RESULTS: Under the allelic association analysis, neither rs1045411T/C nor rs1412125C/T was associated with AF with all P values >0.05; under the genotypic association analysis, the 3'UTR variant rs1045411T showed a marginally significant association with AF under the recessive model (Padj=0.056, OR =0.42; 95% CI: 0.17-1.02). When divided the studied population by gender, we still found no significant association results between the selected variants and AF with P values more than 0.05; however, when divided the population into subgroups by the age onset of AF, we found that the 3'UTR variant rs1045411T was significantly associated with AF in the late-onset subgroup (Padj=0.009, OR =11.1; 95% CI: 1.82-50.0). CONCLUSIONS: The 3'UTR variant rs1045411T/C of HMGB1 might influence the risk of late-onset AF in the Chinese Han population, which provides an important target factor for the prevention and treatment study of AF. 2020 Cardiovascular Diagnosis and Therapy. All rights reserved.
Entities:
Keywords:
Atrial fibrillation (AF); genetic association; high mobility group box 1 (HMGB1)
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