| Literature DB >> 19597491 |
Daniel F Gudbjartsson1, Hilma Holm, Solveig Gretarsdottir, Gudmar Thorleifsson, G Bragi Walters, Gudmundur Thorgeirsson, Jeffrey Gulcher, Ellisiv B Mathiesen, Inger Njølstad, Audhild Nyrnes, Tom Wilsgaard, Erin M Hald, Kristian Hveem, Camilla Stoltenberg, Gayle Kucera, Tanya Stubblefield, Shannon Carter, Dan Roden, Maggie C Y Ng, Larry Baum, Wing Yee So, Ka Sing Wong, Juliana C N Chan, Christian Gieger, H-Erich Wichmann, Andreas Gschwendtner, Martin Dichgans, Gregor Kuhlenbäumer, Klaus Berger, E Bernd Ringelstein, Steve Bevan, Hugh S Markus, Konstantinos Kostulas, Jan Hillert, Sigurlaug Sveinbjörnsdóttir, Einar M Valdimarsson, Maja-Lisa Løchen, Ronald C W Ma, Dawood Darbar, Augustine Kong, David O Arnar, Unnur Thorsteinsdottir, Kari Stefansson.
Abstract
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.Entities:
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Year: 2009 PMID： 19597491 PMCID： PMC2740741 DOI： 10.1038/ng.417
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330