Literature DB >> 32693060

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications.

Oscar A Tarazona1, Olivier Pourquié2.   

Abstract

The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the activation of transcriptional programs. PTMs can control the function of transcription factors acting as master regulators of cell fate as well as activation or repression of cell identity genes by regulating chromatin state via histone tail modifications. It now becomes clear that cell metabolism is an integral part of the complex landscape of regulatory mechanisms underlying cell differentiation.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID: 32693060      PMCID: PMC7458154          DOI: 10.1016/j.devcel.2020.06.035

Source DB:  PubMed          Journal:  Dev Cell        ISSN: 1534-5807            Impact factor:   12.270


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