Literature DB >> 32676930

Utilization of clinical genetic counseling among childhood and young adult cancer survivors in a registry trial.

Nassim Anderson1, Arash Delavar1,2, Danielle Novetsky Friedman1, Vijai Joseph1, Nidha Mubdi1, Kevin C Oeffinger3, Charles A Sklar1, Kenneth Offit1,4, Matthew Matasar1,4, Nirupa Raghunathan1,4, Zoltan Antal1, David Straus1,4, Michael Walsh1, Alicia Latham1,4, Emily S Tonorezos5,6,7.   

Abstract

We describe utilization of clinical genetic services among survivors of childhood and young adult cancer after participation in a genetic registry. Clinical genetic counselors flagged 162 out of 1069 pedigrees (15.2%) as suggestive of inheritable cancer susceptibility, resulting in 126 (11.8%) referral letters. Following delivery of the referral letters, 19 (15.1%) participants completed clinical genetic counseling, 16 (12.7%) received testing, and four (3.2%) were found to have actionable results. Our results suggest a discordance between reported willingness to undergo genetic counseling and real-world utilization.

Entities:  

Keywords:  Cancer survivor; Childhood cancer; Genetic testing; Young adult cancer

Year:  2020        PMID： 32676930      PMCID： PMC7475134          DOI： 10.1007/s12687-020-00478-0

Source DB:  PubMed          Journal:  J Community Genet        ISSN： 1868-310X


  17 in total

Review 1.  Risk communication strategies: state of the art and effectiveness in the context of cancer genetic services.

Authors:  Claire Julian-Reynier; Myriam Welkenhuysen; Lea Hagoel; Marleen Decruyenaere; Penelope Hopwood
Journal:  Eur J Hum Genet       Date:  2003-10       Impact factor: 4.246

2.  Referral to cancer genetic counseling: are there stages of readiness?

Authors:  Suzanne M O'Neill; June A Peters; Victor G Vogel; Eleanor Feingold; Wendy S Rubinstein
Journal:  Am J Med Genet C Semin Med Genet       Date:  2006-11-15       Impact factor: 3.908

3.  A model for patient-direct screening and referral for familial cancer risk.

Authors:  Kristin B Niendorf; Melissa A Geller; Rachel Isaksson Vogel; Timothy R Church; Anna Leininger; Angela Bakke; Robert D Madoff
Journal:  Fam Cancer       Date:  2016-10       Impact factor: 2.375

4.  Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

Authors:  Zhaoming Wang; Carmen L Wilson; John Easton; Andrew Thrasher; Heather Mulder; Qi Liu; Dale J Hedges; Shuoguo Wang; Michael C Rusch; Michael N Edmonson; Shawn Levy; Jennifer Q Lanctot; Eric Caron; Kyla Shelton; Kelsey Currie; Matthew Lear; Aman Patel; Celeste Rosencrance; Ying Shao; Bhavin Vadodaria; Donald Yergeau; Yadav Sapkota; Russell J Brooke; Wonjong Moon; Evadnie Rampersaud; Xiaotu Ma; Ti-Cheng Chang; Stephen V Rice; Cynthia Pepper; Xin Zhou; Xiang Chen; Wenan Chen; Angela Jones; Braden Boone; Matthew J Ehrhardt; Matthew J Krasin; Rebecca M Howell; Nicholas S Phillips; Courtney Lewis; Deokumar Srivastava; Ching-Hon Pui; Chimene A Kesserwan; Gang Wu; Kim E Nichols; James R Downing; Melissa M Hudson; Yutaka Yasui; Leslie L Robison; Jinghui Zhang
Journal:  J Clin Oncol       Date:  2018-05-30       Impact factor: 44.544

5.  Hereditary cancer risk assessment in a pediatric oncology follow-up clinic.

Authors:  Sara Knapke; Rajaram Nagarajan; Judy Correll; Debra Kent; Karen Burns
Journal:  Pediatr Blood Cancer       Date:  2011-08-17       Impact factor: 3.167

6.  Genomic testing in cancer: patient knowledge, attitudes, and expectations.

Authors:  Phillip S Blanchette; Anna Spreafico; Fiona A Miller; Kelvin Chan; Jessica Bytautas; Steve Kang; Philippe L Bedard; Andrea Eisen; Larissa Potanina; Jack Holland; Suzanne Kamel-Reid; John D McPherson; Albiruni R Razak; Lillian L Siu
Journal:  Cancer       Date:  2014-06-24       Impact factor: 6.860

7.  Recall of and reactions to a surgeon referral letter for BRCA genetic counseling among high-risk breast cancer patients.

Authors:  Susan T Vadaparampil; Gwendolyn P Quinn; Cheryl A Miree; Jennifer Brzosowicz; Bradford Carter; Christine Laronga
Journal:  Ann Surg Oncol       Date:  2009-04-30       Impact factor: 5.344

8.  Awareness of cancer susceptibility genetic testing: the 2000, 2005, and 2010 National Health Interview Surveys.

Authors:  Phuong L Mai; Susan Thomas Vadaparampil; Nancy Breen; Timothy S McNeel; Louise Wideroff; Barry I Graubard
Journal:  Am J Prev Med       Date:  2014-05       Impact factor: 5.043

9.  Genetic testing for the risk of developing late effects among survivors of childhood cancer: Consumer understanding, acceptance, and willingness to pay.

Authors:  Gabrielle Georgiou; Claire E Wakefield; Brittany C McGill; Joanna E Fardell; Christina Signorelli; Lucy Hanlon; Kathy Tucker; Andrea F Patenaude; Richard J Cohn
Journal:  Cancer       Date:  2016-06-03       Impact factor: 6.860

10.  A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

Authors:  Heather Hampel; Robin L Bennett; Adam Buchanan; Rachel Pearlman; Georgia L Wiesner
Journal:  Genet Med       Date:  2014-11-13       Impact factor: 8.822
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