Literature DB >> 32672090

Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia.

Samuel Boes1,2, Hugo Botha1, Mary Machulda3, Val Lowe4, Jonathan Graff-Radford1, Jennifer L Whitwell4, Rene L Utianski1, Joseph R Duffy1, Keith A Josephs1.   

Abstract

We report a patient presenting with clinical features of logopenic variant primary progressive aphasia (lvPPA) who was later diagnosed with probable dementia with Lewy bodies. LvPPA is a neurodegenerative disease that is characterized by anomia, word-finding difficulty, impaired comprehension, and phonological errors. The most common underlying pathology for lvPPA is Alzheimer's disease. However, our patient with clinical features of logopenic progressive aphasia was later diagnosed with probable dementia with Lewy bodies. This case demonstrates that lvPPA can also be an initial manifestation of a phenotype of dementia with Lewy bodies.

Entities:  

Keywords:  Logopenic progressive aphasia; alzheimer disease; beta-amyloid (Aβ); dementia with Lewy bodies

Year:  2020        PMID: 32672090      PMCID: PMC7530001          DOI: 10.1080/13554794.2020.1795204

Source DB:  PubMed          Journal:  Neurocase        ISSN: 1355-4794            Impact factor:   0.881


  22 in total

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7.  Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

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Review 10.  Primary progressive aphasia: a clinical approach.

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  1 in total

1.  Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype.

Authors:  Marina Buciuc; Jennifer L Whitwell; Koji Kasanuki; Jonathan Graff-Radford; Mary M Machulda; Joseph R Duffy; Edythe A Strand; Val J Lowe; Neill R Graff-Radford; Beth K Rush; Malgorzata B Franczak; Margaret E Flanagan; Matthew C Baker; Rosa Rademakers; Owen A Ross; Bernardino F Ghetti; Joseph E Parisi; Aditya Raghunathan; R Ross Reichard; Eileen H Bigio; Dennis W Dickson; Keith A Josephs
Journal:  Ann Neurol       Date:  2020-12-17       Impact factor: 10.422

  1 in total

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