Keith A Josephs1, Joseph R Duffy2, Edythe A Strand2, Mary M Machulda3, Matthew L Senjem4, Val J Lowe5, Clifford R Jack6, Jennifer L Whitwell6. 1. Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: Josephs.keith@mayo.edu. 2. Division of Speech Pathology, Department of Neurology, Mayo Clinic, Rochester, MN, USA. 3. Division of Neuropsychology, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. 4. Department of Information Technology, Mayo Clinic, Rochester, MN, USA. 5. Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN, USA. 6. Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Abstract
BACKGROUND: Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear. METHODS: One hundred thirty subjects with PPA or progressive speech apraxia underwent APOE genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between APOE ε4 and PiB status, as well as severity and regional distribution of PiB, was assessed. RESULTS: Forty-five subjects had an APOE ε4 allele and 60 subjects were PiB-positive. The odds ratio for a subject with APOE ε4 being PiB-positive compared with a subject without APOE ε4 being PiB-positive was 10.2 (95% confidence interval, 4.4-25.5; P < .0001). The APOE ε4 allele did not influence regional PiB distribution or severity. CONCLUSION: APOE ε4 increases the risk of β-amyloid deposition in PPA and progressive speech apraxia but does not influence regional β-amyloid distribution or severity.
BACKGROUND:Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear. METHODS: One hundred thirty subjects with PPA or progressive speech apraxia underwent APOE genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between APOE ε4 and PiB status, as well as severity and regional distribution of PiB, was assessed. RESULTS: Forty-five subjects had an APOE ε4 allele and 60 subjects were PiB-positive. The odds ratio for a subject with APOE ε4 being PiB-positive compared with a subject without APOE ε4 being PiB-positive was 10.2 (95% confidence interval, 4.4-25.5; P < .0001). The APOE ε4 allele did not influence regional PiB distribution or severity. CONCLUSION:APOE ε4 increases the risk of β-amyloid deposition in PPA and progressive speech apraxia but does not influence regional β-amyloid distribution or severity.
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