Roberto I Mota1,2,3, Samuel E Morgan1,2, Edward M Bahnson1,2,3,4. 1. Department of Surgery, Division of Vascular Surgery; University of North Carolina at Chapel Hill, NC 27599. 2. Center for Nanotechnology in Drug Delivery; University of North Carolina at Chapel Hill, NC 27599. 3. McAllister Heart Institute, University of North Carolina at Chapel Hill, NC 27599. 4. Department of Cell Biology and Physiology. University of North Carolina at Chapel Hill, NC 27599.
Abstract
PURPOSE OF REVIEW: Diabetes is a common and prevalent medical condition as it affects many lives around the globe. Specifically, type-2 Diabetes (T2D) is characterized by chronic systemic inflammation alongside hyperglycemia and insulin resistance in the body, which can result in atherosclerotic legion formation in the arteries and thus progression of related conditions called diabetic vasculopathies. T2D patients are especially at risk for vascular injury; adjunct in many of these patients heir cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of their vascular system. RECENT FINDINGS: Microvascular and macrovascular vasculopathies as complications of diabetes can accentuate the onset of organ illnesses, thus it is imperative that research efforts help identify more effective methods for prevention and diagnosis of early vascular injuries. Current research into vasculopathy identification/treatment will aid in the amelioration of diabetes-related symptoms and thus reduce the large number of deaths that this disease accounts annually. SUMMARY: This review aims to showcase the evolution and effects of diabetic vasculopathy from development to clinical disease as macrovascular and microvascular complications with a concerted reference to sex-specific disease progression as well.
PURPOSE OF REVIEW: Diabetes is a common and prevalent medical condition as it affects many lives around the globe. Specifically, type-2 Diabetes (T2D) is characterized by chronic systemic inflammation alongside hyperglycemia and insulin resistance in the body, which can result in atherosclerotic legion formation in the arteries and thus progression of related conditions called diabetic vasculopathies. T2D patients are especially at risk for vascular injury; adjunct in many of these patients heir cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of their vascular system. RECENT FINDINGS: Microvascular and macrovascular vasculopathies as complications of diabetes can accentuate the onset of organ illnesses, thus it is imperative that research efforts help identify more effective methods for prevention and diagnosis of early vascular injuries. Current research into vasculopathy identification/treatment will aid in the amelioration of diabetes-related symptoms and thus reduce the large number of deaths that this disease accounts annually. SUMMARY: This review aims to showcase the evolution and effects of diabetic vasculopathy from development to clinical disease as macrovascular and microvascular complications with a concerted reference to sex-specific disease progression as well.
Authors: Jan H von der Thüsen; Keren S Borensztajn; Silvia Moimas; Sandra van Heiningen; Peter Teeling; Theo J C van Berkel; Erik A L Biessen Journal: Am J Pathol Date: 2011-02 Impact factor: 4.307
Authors: Thomas M Bashore; Stephen Balter; Ana Barac; John G Byrne; Jeffrey J Cavendish; Charles E Chambers; James Bernard Hermiller; Scott Kinlay; Joel S Landzberg; Warren K Laskey; Charles R McKay; Julie M Miller; David J Moliterno; John W M Moore; Sandra M Oliver-McNeil; Jeffrey J Popma; Carl L Tommaso Journal: J Am Coll Cardiol Date: 2012-05-08 Impact factor: 24.094
Authors: Ema E Herrera-Lopez; Osvaldo D Castelan-Martinez; Fernando Suarez-Sanchez; Jaime H Gomez-Zamudio; Jose J Peralta-Romero; Miguel Cruz; Adan Valladares-Salgado Journal: Diabetes Metab Syndr Date: 2018-04-12
Authors: Daniel C Pimenta; Benedito C Prezoto; Katsuhiro Konno; Robson L Melo; Maria F Furtado; Antonio C M Camargo; Solange M T Serrano Journal: Rapid Commun Mass Spectrom Date: 2007 Impact factor: 2.419
Authors: Carmel M McVicar; Ross Hamilton; Liza M Colhoun; Tom A Gardiner; Michael Brines; Anthony Cerami; Alan W Stitt Journal: Diabetes Date: 2011-09-12 Impact factor: 9.461
Authors: Lama A Ammar; Mohamad I Nahlawi; Nizar W Shayya; Hilda E Ghadieh; Nadim S Azar; Frédéric Harb; Assaad A Eid Journal: Front Cardiovasc Med Date: 2021-01-28