Fang-Fang Zhao1, Hao-Yuan Gao2, Yuan Gao3, Zhuan Zhao4, Juan Li5, Fang-Bo Ning5, Xin-Na Zhang5, Zhi-Gao Wang6, Ai-Ling Yu5, Yan-Yong Guo7, Bao-Liang Sun8. 1. Department of Neurology, Shandong University School of Medicine, Jinan, Shandong, China; Department of Neurology, Tai'an City Central Hospital, Tai'an, Shandong, China; Department of Neurology, Key Laboratory of Cerebral Microcirculation in Universities of Shandong (Taishan Medical University), Affiliated Hospital of Taishan Medical University, Tai'an, Shandong, China. 2. Department of Cardiology, Affiliated Hospital of Taishan Medical University, Tai'an, Shandong, China. 3. Department of Psychiatry, Jining Psychiatric Hospital, Jining, Shandong, China. 4. Department of Clinical Laboratory, Tai'an Second Chinese Medicine Hospital, Tai'an, Shandong, China. 5. Department of Neurology, Tai'an City Central Hospital, Tai'an, Shandong, China. 6. Department of Statistics, East China Normal University, Shanghai, China. 7. Department of Gamma Knife Center, Jining Psychiatric Hospital, Jining, Shandong, China. 8. Department of Neurology, Key Laboratory of Cerebral Microcirculation in Universities of Shandong (Taishan Medical University), Affiliated Hospital of Taishan Medical University, Tai'an, Shandong, China. Electronic address: ziyingwuyu2005@163.com.
Abstract
PURPOSE: This study aimed to investigate the correlation between cerebral microbleeds and carotid atherosclerosis in patients with ischemic stroke. SUBJECTS AND METHODS: Patients with ischemic stroke treated in a hospital in China from 2016 to 2017 were enrolled in the study. Based on the results from susceptibility-weighted imaging, the patients were divided into cerebral microbleed and noncerebral microbleed groups. The degree of carotid atherosclerosis was assessed with carotid intima-media thickness (CIMB) and Crouse score of carotid plaque. The details of patients' demographic information, cerebrovascular disease-related risk factors, carotid atherosclerosis indices, cerebral microbleed distribution, and grading were recorded, compared, and analyzed. RESULTS: Logistic regression analysis of the 198 patients showed that CIMB and Crouse score were significantly correlated with the occurrence of cerebral microbleeds. The CIMB thickening group (P = .03) and the plaque group (P = .01) were more susceptible to cerebral microbleeds. In the distribution of cerebral microbleed sites, Crouse scores were the highest in the mixed group and showed a statistically significant difference (P < .01). As the degree of carotid atherosclerosis increased, the average number of cerebral microbleeds also increased (P < .01). The receiver operating characteristic curve analysis of the carotid atherosclerosis indices showed a statistically significant difference. The CIMB value combined with the Crouse score was the best indicator (P < .01). CONCLUSION: In patients with ischemic stroke, cerebral microbleeds are closely related to carotid atherosclerosis. Active control of carotid atherosclerosis is important to prevent cerebral microbleeds in patients with ischemic stroke.
PURPOSE: This study aimed to investigate the correlation between cerebral microbleeds and carotid atherosclerosis in patients with ischemic stroke. SUBJECTS AND METHODS: Patients with ischemic stroke treated in a hospital in China from 2016 to 2017 were enrolled in the study. Based on the results from susceptibility-weighted imaging, the patients were divided into cerebral microbleed and noncerebral microbleed groups. The degree of carotid atherosclerosis was assessed with carotid intima-media thickness (CIMB) and Crouse score of carotid plaque. The details of patients' demographic information, cerebrovascular disease-related risk factors, carotid atherosclerosis indices, cerebral microbleed distribution, and grading were recorded, compared, and analyzed. RESULTS: Logistic regression analysis of the 198 patients showed that CIMB and Crouse score were significantly correlated with the occurrence of cerebral microbleeds. The CIMB thickening group (P = .03) and the plaque group (P = .01) were more susceptible to cerebral microbleeds. In the distribution of cerebral microbleed sites, Crouse scores were the highest in the mixed group and showed a statistically significant difference (P < .01). As the degree of carotid atherosclerosis increased, the average number of cerebral microbleeds also increased (P < .01). The receiver operating characteristic curve analysis of the carotid atherosclerosis indices showed a statistically significant difference. The CIMB value combined with the Crouse score was the best indicator (P < .01). CONCLUSION: In patients with ischemic stroke, cerebral microbleeds are closely related to carotid atherosclerosis. Active control of carotid atherosclerosis is important to prevent cerebral microbleeds in patients with ischemic stroke.
Authors: Hediyeh Baradaran; Sinead Culleton; Greg Stoddard; Matthew D Alexander; J Rafael Romero; J Rock Hadley; Seong-Eun Kim; Dennis L Parker; J Scott McNally Journal: Neuroradiology Date: 2022-10-24 Impact factor: 2.995