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Literature DB >> 3263647

Stepwise intraclonal maturation of antibody affinity through somatic hypermutation.

Abstract

Using recombinant DNA techniques, we reconstructed a genealogical tree (Sablitzky, F., Wildner, G. & Rajewsky, K. (1985) EMBO J. 4, 345-350) that connects three clonally related B cells producing somatically mutated antibodies to a progenitor cell expressing a germ line-encoded antibody. The somatic mutants had been isolated from an in vivo immune response. The germ line-encoded progenitor antibody bound the antigen with high affinity. Intraclonal affinity maturation occurred stepwise over a 15-fold range.

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Year: 1988 PMID： 3263647 PMCID： PMC282396 DOI： 10.1073/pnas.85.21.8206

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

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Journal: Eur J Immunol Date: 1978-06 Impact factor: 5.532

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Journal: Nature Date: 1970-08-15 Impact factor: 49.962

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Journal: Adv Immunol Date: 1977 Impact factor: 3.543

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Journal: Eur J Immunol Date: 1977-10 Impact factor: 5.532

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Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

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Authors: D Allen; T Simon; F Sablitzky; K Rajewsky; A Cumano
Journal: EMBO J Date: 1988-07 Impact factor: 11.598

10. Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

Authors: M S Neuberger
Journal: EMBO J Date: 1983 Impact factor: 11.598

59 in total

1. Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally.

Authors: G Esposito; G Texido; U A Betz; H Gu; W Müller; U Klein; K Rajewsky
Journal: Proc Natl Acad Sci U S A Date: 2000-02-01 Impact factor: 11.205

2. Primary humoral antibody response to Coxiella burnetii, the causative agent of Q fever.

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Journal: J Clin Microbiol Date: 1992-08 Impact factor: 5.948

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Authors: S G Lebecque; P J Gearhart
Journal: J Exp Med Date: 1990-12-01 Impact factor: 14.307

4. Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis.

Authors: Roshini S Abraham; Michelle K Manske; Neta S Zuckerman; Abhishek Sohni; Hanna Edelman; Gitit Shahaf; Michael M Timm; Angela Dispenzieri; Morie A Gertz; Ramit Mehr
Journal: J Clin Immunol Date: 2006-12-28 Impact factor: 8.317

5. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice.

Authors: Dominik Schenten; Angela Egert; Manolis Pasparakis; Klaus Rajewsky
Journal: Blood Date: 2006-02-21 Impact factor: 22.113

6. Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.

Authors: Mikyung Kim; Likai Song; James Moon; Zhen-Yu J Sun; Anna Bershteyn; Melissa Hanson; Derek Cain; Selasie Goka; Garnett Kelsoe; Gerhard Wagner; Darrell Irvine; Ellis L Reinherz
Journal: J Biol Chem Date: 2013-09-18 Impact factor: 5.157

7. Affinity maturation of an ERBB2-targeted SPECT imaging peptide by in vivo phage display.

Authors: Benjamin M Larimer; William D Thomas; George P Smith; Susan L Deutscher
Journal: Mol Imaging Biol Date: 2014-08 Impact factor: 3.488

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Authors: J Sharon
Journal: Proc Natl Acad Sci U S A Date: 1990-06 Impact factor: 11.205

9. The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.

Authors: Chun Chou; Daniel J Verbaro; Elena Tonc; Melanie Holmgren; Marina Cella; Marco Colonna; Deepta Bhattacharya; Takeshi Egawa
Journal: Immunity Date: 2016-08-23 Impact factor: 31.745

10. Clonal selection in the germinal centre by regulated proliferation and hypermutation.

Authors: Alexander D Gitlin; Ziv Shulman; Michel C Nussenzweig
Journal: Nature Date: 2014-05-04 Impact factor: 49.962