Literature DB >> 3262338

Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.

E J Rayhel1, D A Prentice, P S Tabor, W H Flurkey, R W Geib, R F Laherty, S B Schnitzer, R Chen, J P Hughes.   

Abstract

Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.

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Year:  1988        PMID： 3262338      PMCID： PMC1149290          DOI： 10.1042/bj2530295

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Control of lymphokine secretion by prostaglandins.

Authors:  D Gordon; M A Bray; J Morley
Journal:  Nature       Date:  1976-07-29       Impact factor: 49.962

2.  Receptor-mediated mitogenic action of prolactin in a rat lymphoma cell line.

Authors:  R P Shiu; H P Elsholtz; T Tanaka; H G Friesen; P W Gout; C T Beer; R L Noble
Journal:  Endocrinology       Date:  1983-07       Impact factor: 4.736

3.  Prostaglandin inhibition of T-cell proliferation is mediated at two levels.

Authors:  P E Baker; J V Fahey; A Munck
Journal:  Cell Immunol       Date:  1981-06       Impact factor: 4.868

4.  Production of prostaglandin E2 by bladder tumor cells in tissue culture and a possible mechanism of lymphocyte inhibition.

Authors:  M J Droller; J A Lindgren; H E Claessen; P Perlmann
Journal:  Cell Immunol       Date:  1979-10       Impact factor: 4.868

5.  Thymic origin of the prolactin-dependent Nb2 lymphoma cell line.

Authors:  W H Fleming; N M Pettigrew; R J Matusik; H G Friesen
Journal:  Cancer Res       Date:  1982-08       Impact factor: 12.701

6.  Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

Authors:  A H Tashjian; E F Voelkel; M Lazzaro; F R Singer; A B Roberts; R Derynck; M E Winkler; L Levine
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

7.  Transforming growth factor-beta: biological function and chemical structure.

Authors:  M B Sporn; A B Roberts; L M Wakefield; R K Assoian
Journal:  Science       Date:  1986-08-01       Impact factor: 47.728

8.  A new sensitive and specific bioassay for lactogenic hormones: measurement of prolactin and growth hormone in human serum.

Authors:  T Tanaka; R P Shiu; P W Gout; C T Beer; R L Noble; H G Friesen
Journal:  J Clin Endocrinol Metab       Date:  1980-11       Impact factor: 5.958

9.  Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

Authors:  A H Rook; J H Kehrl; L M Wakefield; A B Roberts; M B Sporn; D B Burlington; H C Lane; A S Fauci
Journal:  J Immunol       Date:  1986-05-15       Impact factor: 5.422

10.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Authors:  J H Kehrl; L M Wakefield; A B Roberts; S Jakowlew; M Alvarez-Mon; R Derynck; M B Sporn; A S Fauci
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
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  1 in total

1.  Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques.

Authors:  C Bole-Feysot; E Perret; P Roustan; B Bouchard; P A Kelly
Journal:  Genome Biol       Date:  2000-10-16       Impact factor: 13.583
  1 in total

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