Literature DB >> 3859875

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

A H Tashjian, E F Voelkel, M Lazzaro, F R Singer, A B Roberts, R Derynck, M E Winkler, L Levine.   

Abstract

Human alpha and beta transforming growth factors (TGF-alpha and TGF-beta) stimulated the production of prostaglandin E2 (PGE2) and bone resorption in neonatal mouse calvaria in organ culture. Significant stimulation of bone resorption by TGF-alpha was observed with a concentration of 0.2 ng/ml (35 pM) and by TGF-beta with 0.2 ng/ml (8.0 pM). Enhanced production of PGE2 and bone resorption stimulated by either TGF-alpha or TGF-beta were both inhibited by indomethacin. We conclude that TGF-alpha and TGF-beta are potent and powerful stimulators of the resorption of mouse bone by a mechanism that involves the enhanced local production of PGE2.

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Year:  1985        PMID： 3859875      PMCID： PMC391137          DOI： 10.1073/pnas.82.13.4535

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Bone resorption in organ culture: inhibition by the divalent cation ionophores A23187 and X-537A.

Authors:  J L Ivey; D R Wright; A H Tashjian
Journal:  J Clin Invest       Date:  1976-12       Impact factor: 14.808

2.  Growth factors from murine sarcoma virus-transformed cells.

Authors:  J E de Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

3.  Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria.

Authors:  A H Tashjian; L Levine
Journal:  Biochem Biophys Res Commun       Date:  1978-12-14       Impact factor: 3.575

4.  Prostaglandins: stimulation of bone resorption in tissue culture.

Authors:  D C Klein; L G Raisz
Journal:  Endocrinology       Date:  1970-06       Impact factor: 4.736

5.  Specificities of prostaglandins B 1 , F 1 , and F 2 antigen-antibody reactions.

Authors:  L Levine; R M Gjtierrez Cernosek; H Van Vunakis
Journal:  J Biol Chem       Date:  1971-11-25       Impact factor: 5.157

6.  Prostaglandins, calcium metabolism and cancer.

Authors:  A H Tashjian; E F Voelkel; P Goldhaber; L Levine
Journal:  Fed Proc       Date:  1974-01

7.  Arachidonic acid metabolism by cells in culture: analyses of culture fluids for cyclooxygenase products by radioimmunoassay before and after separation by high pressure liquid chromatography.

Authors:  L Levine; I Alam
Journal:  Prostaglandins Med       Date:  1979-11

8.  Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.

Authors:  A B Roberts; L C Lamb; D L Newton; M B Sporn; J E De Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

9.  Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

Authors:  D R Robinson; A H Tashjian; L Levine
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

10.  Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.

Authors:  A H Tashjian; E F Voelkel; L Levine; P Goldhaber
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307
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  49 in total

1.  Expression of epidermal growth factor and transforming growth factor alpha in interfacial membranes retrieved at revision total hip arthroplasty.

Authors:  J W Xu; J Ma; T F Li; E Waris; A Alberty; S Santavirta; Y T Konttinen
Journal:  Ann Rheum Dis       Date:  2000-10       Impact factor: 19.103

2.  Effect of Pasteurella multocida toxin on bone resorption in vitro.

Authors:  R Felix; H Fleisch; P L Frandsen
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

3.  Effects of cyclosporins and transforming growth factor beta 1 on thyroid hormone action in cultured fetal rat limb bones.

Authors:  P Lakatos; P H Stern
Journal:  Calcif Tissue Int       Date:  1992-02       Impact factor: 4.333

Review 4.  Incidence and pathophysiology of hypercalcemia.

Authors:  G R Mundy
Journal:  Calcif Tissue Int       Date:  1990       Impact factor: 4.333

5.  Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.

Authors:  E J Rayhel; D A Prentice; P S Tabor; W H Flurkey; R W Geib; R F Laherty; S B Schnitzer; R Chen; J P Hughes
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

6.  Comparative and combined effects of transforming growth factors alpha and beta, interleukin-1 and interferon-gamma on rheumatoid synovial cell proliferation, glycolysis and prostaglandin E production.

Authors:  D J Taylor; M Feldmann; J M Evanson; D E Woolley
Journal:  Rheumatol Int       Date:  1989       Impact factor: 2.631

7.  Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae.

Authors:  H Kawaguchi; C C Pilbeam; S J Vargas; E E Morse; J A Lorenzo; L G Raisz
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

8.  Parathyroid hormone-related protein: primary osteolytic factor produced by breast tumor cells in vitro?

Authors:  A Tabuenca; S Mohan; C A Garberoglio; P I Borgen; T Rosol; T A Linkhart
Journal:  World J Surg       Date:  1995 Mar-Apr       Impact factor: 3.352

Review 9.  Hypercalcaemia of malignancy.

Authors:  P J Kelly; J A Eisman
Journal:  Cancer Metastasis Rev       Date:  1989-06       Impact factor: 9.264

10.  The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression.

Authors:  A Ayala; D R Meldrum; M M Perrin; I H Chaudry
Journal:  Immunology       Date:  1993-07       Impact factor: 7.397
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