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Literature DB >> 32620705

Neuroinflammation PET Imaging: Current Opinion and Future Directions.

Poorva Jain¹, Aisling M Chaney¹, Mackenzie L Carlson^1,2, Isaac M Jackson¹, Anoushka Rao¹, Michelle L James^3,4.

Abstract

Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant biomarkers. This review analyzes the clinical potential of available and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting future directions for the field.

Entities: Disease Gene

Keywords: biomarker validation; clinical imaging; molecular imaging; neuroinflammation; positron emission tomography

Mesh：

Substances：
Biomarkers

Year: 2020 PMID： 32620705 PMCID： PMC7413228 DOI： 10.2967/jnumed.119.229443

Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057

37 in total

1. Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

Authors: Travis T Wager; Xinjun Hou; Patrick R Verhoest; Anabella Villalobos
Journal: ACS Chem Neurosci Date: 2010-03-25 Impact factor: 4.418

Review 2. Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia.

Authors: William C Kreisl; Ioline D Henter; Robert B Innis
Journal: Adv Pharmacol Date: 2017-11-10

3. Exploratory human PET study of the effectiveness of (11)C-ketoprofen methyl ester, a potential biomarker of neuroinflammatory processes in Alzheimer's disease.

Authors: Akihito Ohnishi; Michio Senda; Tomohiko Yamane; Tomoko Mikami; Hiroyuki Nishida; Tomoyuki Nishio; Go Akamatsu; Yasuhiko Ikari; Shogo Kimoto; Kazuki Aita; Masahiro Sasaki; Hiroko Shinkawa; Yasuji Yamamoto; Miho Shukuri; Aya Mawatari; Hisashi Doi; Yasuyoshi Watanabe; Hirotaka Onoe
Journal: Nucl Med Biol Date: 2016-04-28 Impact factor: 2.408

4. Preclinical ImmunoPET Imaging of Glioblastoma-Infiltrating Myeloid Cells Using Zirconium-89 Labeled Anti-CD11b Antibody.

Authors: Shubhanchi Nigam; Lauren McCarl; Rajeev Kumar; Robert S Edinger; Brenda F Kurland; Carolyn J Anderson; Ashok Panigrahy; Gary Kohanbash; W Barry Edwards
Journal: Mol Imaging Biol Date: 2020-06 Impact factor: 3.488

5. TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study.

Authors: Donatienne Van Weehaeghe; Evelien Van Schoor; Joke De Vocht; Michel Koole; Bala Attili; Sofie Celen; Lieven Declercq; Dietmar R Thal; Philip Van Damme; Guy Bormans; Koen Van Laere
Journal: J Nucl Med Date: 2019-09-27 Impact factor: 11.082

6. Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.

Authors: Alena V Savonenko; Tatiana Melnikova; Yuchuan Wang; Hayden Ravert; Yongjun Gao; Jeremy Koppel; Deidre Lee; Olga Pletnikova; Eugenia Cho; Nuzhat Sayyida; Andrew Hiatt; Juan Troncoso; Peter Davies; Robert F Dannals; Martin G Pomper; Andrew G Horti
Journal: PLoS One Date: 2015-06-18 Impact factor: 3.240

7. ¹¹C-DPA-713 Versus ¹⁸F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke.

Authors: Aisling Chaney; Haley C Cropper; Emily M Johnson; Kendra J Lechtenberg; Todd C Peterson; Marc Y Stevens; Marion S Buckwalter; Michelle L James
Journal: J Nucl Med Date: 2018-07-05 Impact factor: 10.057

Review 8. Therapies for multiple sclerosis targeting B cells.

Authors: Ron Milo
Journal: Croat Med J Date: 2019-04-30 Impact factor: 1.351

9. Synthesis and Initial In Vivo Evaluation of [¹¹C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R).

Authors: Sean S Tanzey; Xia Shao; Jenelle Stauff; Janna Arteaga; Phillip Sherman; Peter J H Scott; Andrew V Mossine
Journal: Pharmaceuticals (Basel) Date: 2018-12-13

Review 10. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

Authors: Vidya Narayanaswami; Kenneth Dahl; Vadim Bernard-Gauthier; Lee Josephson; Paul Cumming; Neil Vasdev
Journal: Mol Imaging Date: 2018 Jan-Dec Impact factor: 4.488

20 in total

1. Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method.

Authors: Yu-Hua Dean Fang; Jonathan E McConathy; Talene A Yacoubian; Yue Zhang; Richard E Kennedy; David G Standaert
Journal: Diagnostics (Basel) Date: 2022-05-07

2. In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI.

Authors: Ruiqing Ni; Adrienne Müller Herde; Ahmed Haider; Claudia Keller; Georgios Louloudis; Markus Vaas; Roger Schibli; Simon M Ametamey; Jan Klohs; Linjing Mu
Journal: Mol Imaging Biol Date: 2021-10-12 Impact factor: 3.484

Neuroinflammation PET Imaging: Current Opinion and Future Directions.

1. Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

Review 2. Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia.

3. Exploratory human PET study of the effectiveness of (11)C-ketoprofen methyl ester, a potential biomarker of neuroinflammatory processes in Alzheimer's disease.

4. Preclinical ImmunoPET Imaging of Glioblastoma-Infiltrating Myeloid Cells Using Zirconium-89 Labeled Anti-CD11b Antibody.

5. TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study.

6. Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.

7. ¹¹C-DPA-713 Versus ¹⁸F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke.

Review 8. Therapies for multiple sclerosis targeting B cells.

9. Synthesis and Initial In Vivo Evaluation of [¹¹C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R).

Review 10. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

1. Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method.

2. In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI.

Review 3. An automated radiosynthesis of [¹⁸F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.

4. In Vitro Evaluation of [³H]CPPC as a Tool Radioligand for CSF-1R.

5. Flortaucipir (tau) PET in LGI1 antibody encephalitis.

Review 6. Modeling Complex Orthopedic Trauma in Rodents: Bone, Muscle and Nerve Injury and Healing.

Review 7. Positron Emission Tomography in Animal Models of Tauopathies.

Review 8. Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders.

9. Synthesis and Evaluation of a ¹⁸F-Labeled Ligand for PET Imaging of Colony-Stimulating Factor 1 Receptor.

Review 10. Imaging Biomarkers for Monitoring the Inflammatory Redox Landscape in the Brain.

Review 2. Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia.

Review 8. Therapies for multiple sclerosis targeting B cells.

Review 10. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

Review 3. An automated radiosynthesis of [18F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.

Review 6. Modeling Complex Orthopedic Trauma in Rodents: Bone, Muscle and Nerve Injury and Healing.

Review 7. Positron Emission Tomography in Animal Models of Tauopathies.

Review 8. Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders.

Review 10. Imaging Biomarkers for Monitoring the Inflammatory Redox Landscape in the Brain.

Review 3. An automated radiosynthesis of [¹⁸F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.