Literature DB >> 34871885

An automated radiosynthesis of [18F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.

Katelyenn S McCauley1, Justin H Wilde1, Sophia M Bufalino2, Kiel D Neumann3.   

Abstract

[18F]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [18F]DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Automation; F-18; Fluorine-18; Positron emission tomography; Radiochemistry; Radiosynthesis

Year:  2021        PMID： 34871885      PMCID： PMC8858596          DOI： 10.1016/j.apradiso.2021.110032

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  23 in total

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Authors:  Uwe-Karsten Hanisch; Helmut Kettenmann
Journal:  Nat Neurosci       Date:  2007-11       Impact factor: 24.884

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Authors:  Vassilios Papadopoulos; Mario Baraldi; Tomás R Guilarte; Thomas B Knudsen; Jean-Jacques Lacapère; Peter Lindemann; Michael D Norenberg; David Nutt; Abraham Weizman; Ming-Rong Zhang; Moshe Gavish
Journal:  Trends Pharmacol Sci       Date:  2006-07-05       Impact factor: 14.819

3.  Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation.

Authors:  Nicolas Arlicot; Johnny Vercouillie; Maria-João Ribeiro; Clovis Tauber; Yann Venel; Jean-Louis Baulieu; Serge Maia; Philippe Corcia; Michael G Stabin; Aaron Reynolds; Michael Kassiou; Denis Guilloteau
Journal:  Nucl Med Biol       Date:  2011-12-14       Impact factor: 2.408

4.  Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans.

Authors:  Christopher J Endres; Martin G Pomper; Michelle James; Ovsev Uzuner; Dima A Hammoud; Crystal C Watkins; Aaron Reynolds; John Hilton; Robert F Dannals; Michael Kassiou
Journal:  J Nucl Med       Date:  2009-07-17       Impact factor: 10.057

5.  DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization.

Authors:  Michelle L James; Roger R Fulton; Johnny Vercoullie; David J Henderson; Lucette Garreau; Sylvie Chalon; Frederic Dolle; Barbara Costa; Silvia Selleri; Denis Guilloteau; Michael Kassiou
Journal:  J Nucl Med       Date:  2008-04-15       Impact factor: 10.057

6.  Parametric Binding Images of the TSPO Ligand 18F-DPA-714.

Authors:  Sandeep S V Golla; Ronald Boellaard; Vesa Oikonen; Anja Hoffmann; Bart N M van Berckel; Albert D Windhorst; Jere Virta; Erik T Te Beek; Geert Jan Groeneveld; Merja Haaparanta-Solin; Pauliina Luoto; Nina Savisto; Olof Solin; Ray Valencia; Andrea Thiele; Jonas Eriksson; Robert C Schuit; Adriaan A Lammertsma; Juha O Rinne
Journal:  J Nucl Med       Date:  2016-06-03       Impact factor: 10.057

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8.  Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients.

Authors:  Sandeep S V Golla; Ronald Boellaard; Vesa Oikonen; Anja Hoffmann; Bart N M van Berckel; Albert D Windhorst; Jere Virta; Merja Haaparanta-Solin; Pauliina Luoto; Nina Savisto; Olof Solin; Ray Valencia; Andrea Thiele; Jonas Eriksson; Robert C Schuit; Adriaan A Lammertsma; Juha O Rinne
Journal:  J Cereb Blood Flow Metab       Date:  2015-02-04       Impact factor: 6.200

9.  [18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model.

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Journal:  Molecules       Date:  2018-06-07       Impact factor: 4.411

10.  Could (18) F-DPA-714 PET imaging be interesting to use in the early post-stroke period?

Authors:  Maria-Joao Ribeiro; Johnny Vercouillie; Severine Debiais; Jean-Philippe Cottier; Isabelle Bonnaud; Vincent Camus; Samuel Banister; Michael Kassiou; Nicolas Arlicot; Denis Guilloteau
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