Bálint Károly Lakatos1, Yosuke Nabeshima2, Márton Tokodi1, Yasufumi Nagata2, Zoltán Tősér3, Kyoko Otani4, Tetsuji Kitano4, Alexandra Fábián1, Adrienn Ujvári1, András Mihály Boros1, Béla Merkely1, Attila Kovács5, Masaaki Takeuchi4. 1. Semmelweis University, Heart and Vascular Center, Budapest, Hungary. 2. Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. 3. Argus Cognitive, Inc., Lebanon, New Hampshire. 4. Department of Laboratory and Transfusion Medicine, Hospital of University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. 5. Semmelweis University, Heart and Vascular Center, Budapest, Hungary. Electronic address: attila.kovacs@med.semmelweis-univ.hu.
Abstract
BACKGROUND: Global right ventricular (RV) function is determined by the interplay of different motion components related to the myofiber architecture, and the relative importance of these components is still not thoroughly characterized. The aims of this study were to quantify the relative contributions of longitudinal, radial, and anteroposterior motion components to global RV function and to examine their determining factors in a large cohort of healthy volunteers using three-dimensional echocardiography. METHODS: Three hundred healthy adults with a balanced age range and an equal sex distribution were investigated at two centers. A three-dimensional mesh model of the right ventricle was generated, and its motion was decomposed along the three anatomically relevant axes. Multiplicative relative contributions were measured by dividing the ejection fraction (EF) values generated by shortening in the longitudinal, radial, and anteroposterior directions by global RV EF (longitudinal EF index [LEFi], radial EF index [REFi], and anteroposterior EF index, respectively). The circumferential contribution was defined as shortening in the radial and anteroposterior directions, omitting only longitudinal shortening. RESULTS: Circumferential EF index was markedly higher compared with LEFi (79 ± 7% vs 47 ± 9%, P < .001). LEFi (47 ± 9%) and anteroposterior EF index (49 ± 7%) were found to be similar in the pooled population, whereas REFi (44 ± 10%) was lower (P < .001). In younger individuals (20-39 years of age), the relative contribution of longitudinal shortening was significantly higher compared with the radial component; however, in the older age groups, LEFi and REFi were comparable. Age, body surface area, heart rate, and RV end-diastolic volume were independent predictors of LEFi and REFi, but all with opposite effects on the two motion directions. CONCLUSIONS: In contrast to the traditional viewpoint, the contributions of the radial and anteroposterior motion directions may be of comparable significance with that of longitudinal shortening in determining global RV function. Standard parameters referring only to longitudinal shortening of the right ventricle may be inadequate to characterize RV function thoroughly.
BACKGROUND: Global right ventricular (RV) function is determined by the interplay of different motion components related to the myofiber architecture, and the relative importance of these components is still not thoroughly characterized. The aims of this study were to quantify the relative contributions of longitudinal, radial, and anteroposterior motion components to global RV function and to examine their determining factors in a large cohort of healthy volunteers using three-dimensional echocardiography. METHODS: Three hundred healthy adults with a balanced age range and an equal sex distribution were investigated at two centers. A three-dimensional mesh model of the right ventricle was generated, and its motion was decomposed along the three anatomically relevant axes. Multiplicative relative contributions were measured by dividing the ejection fraction (EF) values generated by shortening in the longitudinal, radial, and anteroposterior directions by global RV EF (longitudinal EF index [LEFi], radial EF index [REFi], and anteroposterior EF index, respectively). The circumferential contribution was defined as shortening in the radial and anteroposterior directions, omitting only longitudinal shortening. RESULTS: Circumferential EF index was markedly higher compared with LEFi (79 ± 7% vs 47 ± 9%, P < .001). LEFi (47 ± 9%) and anteroposterior EF index (49 ± 7%) were found to be similar in the pooled population, whereas REFi (44 ± 10%) was lower (P < .001). In younger individuals (20-39 years of age), the relative contribution of longitudinal shortening was significantly higher compared with the radial component; however, in the older age groups, LEFi and REFi were comparable. Age, body surface area, heart rate, and RV end-diastolic volume were independent predictors of LEFi and REFi, but all with opposite effects on the two motion directions. CONCLUSIONS: In contrast to the traditional viewpoint, the contributions of the radial and anteroposterior motion directions may be of comparable significance with that of longitudinal shortening in determining global RV function. Standard parameters referring only to longitudinal shortening of the right ventricle may be inadequate to characterize RV function thoroughly.
Authors: Patrick T Hussey; Gregory von Mering; Navin C Nanda; Mustafa I Ahmed; Dylan R Addis Journal: Echocardiography Date: 2022-01-07 Impact factor: 1.874
Authors: Anna Réka Kiss; Zsófia Gregor; Adrián Popovics; Kinga Grebur; Liliána Erzsébet Szabó; Zsófia Dohy; Attila Kovács; Bálint Károly Lakatos; Béla Merkely; Hajnalka Vágó; Andrea Szũcs Journal: Front Cardiovasc Med Date: 2022-04-12
Authors: Zuzanna Lewicka-Potocka; Anna Maria Kaleta-Duss; Ewa Lewicka; Marcin Kubik; Anna Faran; Paweł Szymeczko; Rafał Gała Ska; Grzegorz Raczak; Alicja Da Browska-Kugacka Journal: Front Physiol Date: 2022-01-10 Impact factor: 4.566
Authors: Elena Surkova; Attila Kovács; Márton Tokodi; Bálint Károly Lakatos; Béla Merkely; Denisa Muraru; Alessandro Ruocco; Gianfranco Parati; Luigi P Badano Journal: Circ Cardiovasc Imaging Date: 2021-09-30 Impact factor: 7.792