Consuelo Rosa1,2, Andrea Delli Pizzi2,3, Antonietta Augurio4, Luciana Caravatta4, Monica DI Tommaso4, Erica Mincuzzi3, Sebastiano Cinalli5, Raffaella Basilico3, Annamaria Porreca6, Marta DI Nicola7, Domenico Genovesi4,2. 1. Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University, Chieti, Italy c.rosa155@gmail.com. 2. Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University, Chieti, Italy. 3. Department of Radiology, SS. Annunziata Hospital, G. D'Annunzio University, Chieti, Italy. 4. Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University, Chieti, Italy. 5. Division of Pathology, SS. Annunziata Hospital, Chieti, Italy. 6. Department of Economy, G. D'Annunzio University, Chieti, Italy. 7. Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, G. D'Annunzio University, Chieti, Italy.
Abstract
AIM: To delineate cervical cancer gross tumor volume (GTV) on T2-magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) maps, assessing volumes and inter-observer agreement between two observers. PATIENTS AND METHODS: A radiologist and a radiation oncologist delineated GTV on T2 (T2GTV) and ADC (ADCGTV) sequences. Dice similarity index (DICE) and Bland-Altman analysis were used to estimated concordance. RESULTS: Mean T2GTV and ADCGTV volumes were 43.84±71.47 cc and 37.28±68.92 cc according to the radiologist, and 43.4±70.44 cc and 36.65±69.21 cc according to the radiation oncologist. ADC led to statistically significantly smaller volumes compared to T2. The mean DICE index was 0.86 for T2GTV and 0.84 for ADCGTV The Bland-Altman plots globally showed concordance. CONCLUSION: GTV delineation was smaller in the ADC maps compared to T2-MRI, reaching an almost perfect agreement between observers. Thanks to this acceptable variability, adding functional imaging might provide more information for tumor delineation, improving reproducibility for image-guided adaptive radiotherapy. Copyright
AIM: To delineate cervical cancer gross tumor volume (GTV) on T2-magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) maps, assessing volumes and inter-observer agreement between two observers. PATIENTS AND METHODS: A radiologist and a radiation oncologist delineated GTV on T2 (T2GTV) and ADC (ADCGTV) sequences. Dice similarity index (DICE) and Bland-Altman analysis were used to estimated concordance. RESULTS: Mean T2GTV and ADCGTV volumes were 43.84±71.47 cc and 37.28±68.92 cc according to the radiologist, and 43.4±70.44 cc and 36.65±69.21 cc according to the radiation oncologist. ADC led to statistically significantly smaller volumes compared to T2. The mean DICE index was 0.86 for T2GTV and 0.84 for ADCGTV The Bland-Altman plots globally showed concordance. CONCLUSION:GTV delineation was smaller in the ADC maps compared to T2-MRI, reaching an almost perfect agreement between observers. Thanks to this acceptable variability, adding functional imaging might provide more information for tumor delineation, improving reproducibility for image-guided adaptive radiotherapy. Copyright
Authors: Christine Haie-Meder; Richard Pötter; Erik Van Limbergen; Edith Briot; Marisol De Brabandere; Johannes Dimopoulos; Isabelle Dumas; Taran Paulsen Hellebust; Christian Kirisits; Stefan Lang; Sabine Muschitz; Juliana Nevinson; An Nulens; Peter Petrow; Natascha Wachter-Gerstner Journal: Radiother Oncol Date: 2005-03 Impact factor: 6.280
Authors: Søren Haack; Erik Morre Pedersen; Sune N Jespersen; Jesper F Kallehauge; Jacob Christian Lindegaard; Kari Tanderup Journal: Acta Oncol Date: 2010-10 Impact factor: 4.089
Authors: Primož Petrič; Robert Hudej; Peter Rogelj; Mateja Blas; Kari Tanderup; Elena Fidarova; Christian Kirisits; Daniel Berger; Johannes Carl Athanasios Dimopoulos; Richard Pötter; Taran Paulsen Hellebust Journal: Radiother Oncol Date: 2013-02-27 Impact factor: 6.280