BACKGROUND/AIM: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection. PATIENTS AND METHODS: Fifty-three patients who underwent surgical resection for GBC between January 2008 and September 2019 were enrolled. We retrospectively investigated the relation between preoperative CAR and overall and disease-free survival. RESULTS: The optimal cut-off CAR was 0.07. Multivariate analysis showed that i) R1 or R2 resection (p=0.033), ii) advanced tumor stage (p=0.047), iii) CAR≥0.07 (p=0.011), and iv) postoperative complications (p=0.028) were significant independent predictors of overall survival; moreover, higher carbohydrate antigen levels (p=0.036) and R1 or R2 resection (p<0.001) were significant independent predictors of disease-free survival. CONCLUSION: Preoperative CAR may be a significant independent predictor of long-term outcomes after GBC resection. Copyright
BACKGROUND/AIM: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection. PATIENTS AND METHODS: Fifty-three patients who underwent surgical resection for GBC between January 2008 and September 2019 were enrolled. We retrospectively investigated the relation between preoperative CAR and overall and disease-free survival. RESULTS: The optimal cut-off CAR was 0.07. Multivariate analysis showed that i) R1 or R2 resection (p=0.033), ii) advanced tumor stage (p=0.047), iii) CAR≥0.07 (p=0.011), and iv) postoperative complications (p=0.028) were significant independent predictors of overall survival; moreover, higher carbohydrate antigen levels (p=0.036) and R1 or R2 resection (p<0.001) were significant independent predictors of disease-free survival. CONCLUSION: Preoperative CAR may be a significant independent predictor of long-term outcomes after GBC resection. Copyright
Authors: Katharina Cziupka; Lars Ivo Partecke; Lutz Mirow; Claus-Dieter Heidecke; Christian Emde; Wolfgang Hoffmann; Ulrike Siewert; Neeltje van den Berg; Wolfram von Bernstorff; Albrecht Stier Journal: Langenbecks Arch Surg Date: 2012-03-28 Impact factor: 3.445
Authors: Otavio T Ranzani; Fernando Godinho Zampieri; Daniel Neves Forte; Luciano Cesar Pontes Azevedo; Marcelo Park Journal: PLoS One Date: 2013-03-12 Impact factor: 3.240