OBJECTIVE: To compare serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers. METHODS: Twenty five endometriosis patients (ASRM stage III-IV) and 13 controls were followed through one menstrual cycle. VEGF, TNF-alpha and CRP concentrations were measured with enzyme-linked immunosorbent assay in each of the four cycle phases (early and late proliferative and early and late secretory). Non-parametric methods and Pearson's correlation coefficients were used for statistical analysis. RESULTS: Increased serum levels of VEGF in secretory phases and of TNF-alpha in all cycle phases were observed. A positive correlation between CRP and VEGF was found in endometriosis patients but not in controls. CONCLUSIONS: Our results suggest that excessive systemic angiogenic activity is a feature of patients with endometriosis.
OBJECTIVE: To compare serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers. METHODS: Twenty five endometriosispatients (ASRM stage III-IV) and 13 controls were followed through one menstrual cycle. VEGF, TNF-alpha and CRP concentrations were measured with enzyme-linked immunosorbent assay in each of the four cycle phases (early and late proliferative and early and late secretory). Non-parametric methods and Pearson's correlation coefficients were used for statistical analysis. RESULTS: Increased serum levels of VEGF in secretory phases and of TNF-alpha in all cycle phases were observed. A positive correlation between CRP and VEGF was found in endometriosispatients but not in controls. CONCLUSIONS: Our results suggest that excessive systemic angiogenic activity is a feature of patients with endometriosis.
Authors: Vicki Nisenblat; Patrick M M Bossuyt; Rabia Shaikh; Cindy Farquhar; Vanessa Jordan; Carola S Scheffers; Ben Willem J Mol; Neil Johnson; M Louise Hull Journal: Cochrane Database Syst Rev Date: 2016-05-01
Authors: Fan Mu; Holly R Harris; Janet W Rich-Edwards; Susan E Hankinson; Eric B Rimm; Donna Spiegelman; Stacey A Missmer Journal: Am J Epidemiol Date: 2018-03-01 Impact factor: 4.897