Literature DB >> 3259095

Effect of propofol on cerebral blood flow and metabolism in man.

A Vandesteene1, V Trempont, E Engelman, T Deloof, M Focroul, A Schoutens, M de Rood.   

Abstract

Cerebral blood flow, cerebral oxygen consumption, lactate and glucose metabolism were measured in 13 patients during anaesthesia with nitrous oxide, oxygen and enflurane 0.5% and after 30 minutes infusion of propofol. The mean blood concentration of propofol was 4.06 micrograms/ml. Cerebral blood flow decreased by 27.6% and cerebral vascular resistance by 51%. There were no changes in lactate and glucose metabolism. Cerebral oxygen consumption decreased by 18.25%. Changes in the electro-encephalograph were related to the blood levels of propofol.

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Year:  1988        PMID： 3259095     DOI： 10.1111/j.1365-2044.1988.tb09067.x

Source DB:  PubMed          Journal:  Anaesthesia        ISSN： 0003-2409            Impact factor:   6.955


  22 in total

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