Literature DB >> 3258747

Enhanced production of interleukin-2 in patients with progressive systemic sclerosis. Hyperactivity of CD4-positive T cells?

H Umehara1, S Kumagai, H Ishida, T Suginoshita, M Maeda, H Imura.   

Abstract

A significant enhancement of interleukin-2 production was observed in phytohemagglutinin-stimulated peripheral lymphocytes from patients with progressive systemic sclerosis (PSS). Their Leu-3a:Leu-2a ratio was also significantly higher than normal. Moreover, Leu-3a+ cells freshly purified from PSS patients' blood produced much more interleukin-2 than did cells from normal subjects. These results suggest that T cell hyperactivity, especially among Leu-3a+ T cells, occurs in patients with PSS.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3258747     DOI： 10.1002/art.1780310312

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  13 in total

1.  Imbalance of CD4+ lymphocyte subsets in patients with mixed connective tissue disease.

Authors:  H Becker; A Langrock; K Federlin
Journal:  Clin Exp Immunol       Date:  1992-04       Impact factor: 4.330

2.  Increased concentrations of soluble interleukin-2 receptor in the serum of patients with systemic sclerosis.

Authors:  P Airò; M Bettinzioli; R Gorla; R Cattaneo
Journal:  Ann Rheum Dis       Date:  1991-04       Impact factor: 19.103

3.  Abnormalities of T lymphocyte subsets in systemic sclerosis demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies.

Authors:  A Kahan; A Kahan; F Picard; C J Menkès; B Amor
Journal:  Ann Rheum Dis       Date:  1991-06       Impact factor: 19.103

Review 4.  The endothelium: its role in scleroderma.

Authors:  J D Pearson
Journal:  Ann Rheum Dis       Date:  1991-11       Impact factor: 19.103

5.  Detection of circulating Fc epsilon R2/CD23+ monocytes in patients with rheumatic diseases.

Authors:  H Becker; P Potyka; C Weber; K Federlin
Journal:  Clin Exp Immunol       Date:  1991-07       Impact factor: 4.330

6.  Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis.

Authors:  G Famularo; A Procopio; R Giacomelli; C Danese; S Sacchetti; M A Perego; A Santoni; G Tonietti
Journal:  Clin Exp Immunol       Date:  1990-09       Impact factor: 4.330

7.  CD4+ and CD8+ subsets: naive and memory cells in the peripheral blood of patients with systemic sclerosis.

Authors:  R Gorla; P Airò; A Malagoli; G Carella; E Prati; D Brugnoni; F Franceschini; R Cattaneo
Journal:  Clin Rheumatol       Date:  1994-03       Impact factor: 2.980

8.  Early phenotypic activation of circulating helper memory T cells in scleroderma: correlation with disease activity.

Authors:  U Fiocco; M Rosada; L Cozzi; C Ortolani; G De Silvestro; A Ruffatti; E Cozzi; C Gallo; S Todesco
Journal:  Ann Rheum Dis       Date:  1993-04       Impact factor: 19.103

9.  Enhanced production of transforming growth factor-beta (TGF-beta) during autologous mixed lymphocyte reaction of systemic sclerosis patients.

Authors:  H Ota; S Kumagai; A Morinobu; H Yanagida; K Nakao
Journal:  Clin Exp Immunol       Date:  1995-04       Impact factor: 4.330

10.  Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma.

Authors:  H Ihn; S Sato; M Fujimoto; K Kikuchi; K Takehara
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.