Literature DB >> 8187450

CD4+ and CD8+ subsets: naive and memory cells in the peripheral blood of patients with systemic sclerosis.

R Gorla1, P Airò, A Malagoli, G Carella, E Prati, D Brugnoni, F Franceschini, R Cattaneo.   

Abstract

Systemic Sclerosis (SSc; scleroderma) is associated with several immunological abnormalities, including altered proportion between lymphocyte subsets. Peripheral blood lymphocyte subsets from 25 patients with SSc were studied by two-colour flow cytometry using monoclonal antibodies against CD45RA and CD29 markers, which allow a dissection of CD4+ and CD8+ populations into 'naive' and 'memory' subsets. A decrease of the percentage of CD8+ (p < 0.05) and of CD8+CD29+ (p < 0.001) cells was observed compared to that in 20 age and sex-matched controls. These abnormalities were not significantly associated with the extension of cutaneous disease or other clinical features of SSc nor with treatment, pattern of autoantibodies or HLA phenotype.

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Year:  1994        PMID： 8187450     DOI： 10.1007/bf02229871

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  31 in total

Review 1.  Genetic factors in scleroderma.

Authors:  D Briggs; C Black; K Welsh
Journal:  Rheum Dis Clin North Am       Date:  1990-02       Impact factor: 2.670

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Authors:  M Grazia Cifone; R Giacomelli; G Famularo; R Paolini; C Danese; T Napolitano; A Procopio; A M Perego; A Santoni; G Tonietti
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3.  Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones.

Authors:  J Koide; E G Engleman
Journal:  J Immunol       Date:  1990-01-01       Impact factor: 5.422

4.  Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

Authors:  H M Serra; J F Krowka; J A Ledbetter; L M Pilarski
Journal:  J Immunol       Date:  1988-03-01       Impact factor: 5.422

5.  The isolation and characterization of the human helper inducer T cell subset.

Authors:  C Morimoto; N L Letvin; A W Boyd; M Hagan; H M Brown; M M Kornacki; S F Schlossman
Journal:  J Immunol       Date:  1985-06       Impact factor: 5.422

6.  Enhanced production of interleukin-2 in patients with progressive systemic sclerosis. Hyperactivity of CD4-positive T cells?

Authors:  H Umehara; S Kumagai; H Ishida; T Suginoshita; M Maeda; H Imura
Journal:  Arthritis Rheum       Date:  1988-03

7.  Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis.

Authors:  G Famularo; A Procopio; R Giacomelli; C Danese; S Sacchetti; M A Perego; A Santoni; G Tonietti
Journal:  Clin Exp Immunol       Date:  1990-09       Impact factor: 4.330

8.  Identification of antibodies to acidic antigens by counterimmunoelectrophoresis.

Authors:  R M Bernstein; C C Bunn; G R Hughes
Journal:  Ann Rheum Dis       Date:  1982-10       Impact factor: 19.103

9.  Phenotype of peripheral blood lymphocytes in patients with progressive systemic sclerosis: activated T lymphocytes and the effect of D-penicillamine therapy.

Authors:  B Freundlich; S A Jimenez
Journal:  Clin Exp Immunol       Date:  1987-08       Impact factor: 4.330

10.  Functional and phenotypic analysis of T lymphocytes cloned from the skin of patients with systemic sclerosis.

Authors:  M Ferrarini; V Steen; T A Medsger; T L Whiteside
Journal:  Clin Exp Immunol       Date:  1990-03       Impact factor: 4.330
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  7 in total

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4.  Response of T-cell subpopulations to superantigen and recall antigen stimulation in systemic sclerosis.

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5.  Cytometric Characterization of Main Immunocompetent Cells in Patients with Systemic Sclerosis: Relationship with Disease Activity and Type of Immunosuppressive Treatment.

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Review 6.  Natural Killer Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases?

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7.  The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.

Authors:  Timothy R D J Radstake; Lenny van Bon; Jasper Broen; Anila Hussiani; Roger Hesselstrand; Dirk M Wuttge; Yanhui Deng; Robbert Simms; Erik Lubberts; Robert Lafyatis
Journal:  PLoS One       Date:  2009-06-17       Impact factor: 3.240
  7 in total

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