Literature DB >> 1711833

Abnormalities of T lymphocyte subsets in systemic sclerosis demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies.

A Kahan1, A Kahan1, F Picard, C J Menkès, B Amor.   

Abstract

T cell subpopulations were assessed by two colour flow cytometry with phycoerythrin conjugated anti-CD45RA and anti-CD29 and fluorescein conjugated anti-CD4 and anti-CD8 monoclonal antibodies, on peripheral blood lymphocytes from 12 patients with systemic sclerosis and from nine control subjects. The percentage of CD4+CD29+ cells was significantly higher in patients with systemic sclerosis than in controls (mean (SEM) 68.8 (3.1) v 47.9 (4.1) respectively). CD4+CD45RA+ cells were not significantly different in patients and controls. CD8+CD29+ and CD8+CD45RA+ subpopulations were significantly higher in patients with systemic sclerosis than in controls (83.0 (3.2) v 58.7 (6.8) and 80.2 (3.0) v 66.9 (3.2) respectively). The increase in the percentage of CD29+ cells suggests an activation of memory cells in patients with systemic sclerosis, which may play an important part in the pathogenesis of the disease.

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Year:  1991        PMID： 1711833      PMCID： PMC1004435          DOI： 10.1136/ard.50.6.354

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  25 in total

1.  Increased proto-oncogene expression in peripheral blood T lymphocytes from patients with systemic sclerosis.

Authors:  A Kahan; J Gerfaux; A Kahan; A M Joret; C J Menkès; B Amor
Journal:  Arthritis Rheum       Date:  1989-04

2.  Enhanced production of interleukin-2 in patients with progressive systemic sclerosis. Hyperactivity of CD4-positive T cells?

Authors:  H Umehara; S Kumagai; H Ishida; T Suginoshita; M Maeda; H Imura
Journal:  Arthritis Rheum       Date:  1988-03

3.  The T4 molecule differentially regulating the activation of subpopulations of T4+ cells.

Authors:  T Takeuchi; S F Schlossman; C Morimoto
Journal:  J Immunol       Date:  1987-08-01       Impact factor: 5.422

4.  Functional heterogeneity of CD4+ T lymphocytes: two subpopulations with counteracting immunoregulatory functions identified with the monoclonal antibodies WR16 and WR19.

Authors:  K Moore; A M Nesbitt
Journal:  Immunology       Date:  1987-06       Impact factor: 7.397

5.  Suppressor cell function and T lymphocyte subpopulations in peripheral blood of patients with progressive systemic sclerosis.

Authors:  T L Whiteside; Y Kumagai; A D Roumm; R Almendinger; G P Rodnan
Journal:  Arthritis Rheum       Date:  1983-07

6.  The isolation and characterization of the human suppressor inducer T cell subset.

Authors:  C Morimoto; N L Letvin; J A Distaso; W R Aldrich; S F Schlossman
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

7.  Phenotype of peripheral blood lymphocytes in patients with progressive systemic sclerosis: activated T lymphocytes and the effect of D-penicillamine therapy.

Authors:  B Freundlich; S A Jimenez
Journal:  Clin Exp Immunol       Date:  1987-08       Impact factor: 4.330

8.  Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint.

Authors:  C Pitzalis; G Kingsley; J Murphy; G Panayi
Journal:  Clin Immunol Immunopathol       Date:  1987-11

9.  Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population.

Authors:  P De Paoli; S Battistin; G F Santini
Journal:  Clin Immunol Immunopathol       Date:  1988-09

10.  Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

Authors:  M E Sanders; M W Makgoba; S O Sharrow; D Stephany; T A Springer; H A Young; S Shaw
Journal:  J Immunol       Date:  1988-03-01       Impact factor: 5.422
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  6 in total

1.  CD4+ and CD8+ subsets: naive and memory cells in the peripheral blood of patients with systemic sclerosis.

Authors:  R Gorla; P Airò; A Malagoli; G Carella; E Prati; D Brugnoni; F Franceschini; R Cattaneo
Journal:  Clin Rheumatol       Date:  1994-03       Impact factor: 2.980

2.  Early phenotypic activation of circulating helper memory T cells in scleroderma: correlation with disease activity.

Authors:  U Fiocco; M Rosada; L Cozzi; C Ortolani; G De Silvestro; A Ruffatti; E Cozzi; C Gallo; S Todesco
Journal:  Ann Rheum Dis       Date:  1993-04       Impact factor: 19.103

3.  Increased frequency of in vivo hprt gene-mutated T cells in the peripheral blood of patients with systemic sclerosis.

Authors:  P P Sfikakis; J Tesar; S Theocharis; G L Klipple; G C Tsokos
Journal:  Ann Rheum Dis       Date:  1994-02       Impact factor: 19.103

Review 4.  T and NK Cell Phenotypic Abnormalities in Systemic Sclerosis: a Cohort Study and a Comprehensive Literature Review.

Authors:  Isabel Almeida; Sara Vieira Silva; Ana Raquel Fonseca; Ivone Silva; Carlos Vasconcelos; Margarida Lima
Journal:  Clin Rev Allergy Immunol       Date:  2015-12       Impact factor: 8.667

5.  Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis.

Authors:  Thilo Gambichler; C Tigges; B Burkert; S Höxtermann; P Altmeyer; A Kreuter
Journal:  Eur J Med Res       Date:  2010-01-29       Impact factor: 2.175

6.  Cytometric Characterization of Main Immunocompetent Cells in Patients with Systemic Sclerosis: Relationship with Disease Activity and Type of Immunosuppressive Treatment.

Authors:  Olga Gumkowska-Sroka; Krystyna Jagoda; Aleksander Owczarek; Grzegorz Helbig; Joanna Giemza-Stokłosa; Przemysław J Kotyla
Journal:  J Clin Med       Date:  2019-05-08       Impact factor: 4.241
  6 in total

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