| Literature DB >> 32586993 |
Elena Kuzmin1,2, Benjamin VanderSluis3, Alex N Nguyen Ba4,5, Wen Wang3, Elizabeth N Koch3, Matej Usaj1, Anton Khmelinskii6, Mojca Mattiazzi Usaj1, Jolanda van Leeuwen1, Oren Kraus1,2, Amy Tresenrider7, Michael Pryszlak1,2, Ming-Che Hu1, Brenda Varriano1, Michael Costanzo1, Michael Knop6,8, Alan Moses4,5,9, Chad L Myers10, Brenda J Andrews11,2, Charles Boone11,2.
Abstract
Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: a more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors.Entities:
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Year: 2020 PMID： 32586993 PMCID： PMC7539174 DOI： 10.1126/science.aaz5667
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728