Michael Strupp1, Julia Dlugaiczyk, Birgit Bettina Ertl-Wagner, Dan Rujescu, Martin Westhofen, Marianne Dieterich. 1. Department of Neurology, Ludwig Maximilians University, Munich (LMU); German Center for Dizziness and Balance Disorders, Ludwig Maximilians University, Munich (LMU); Medical Imaging, University of Toronto, Canada; University Clinic and Outpatient Department for Psychiatry, Psychotherapy and Psychosomatics, University of Halle-Wittenberg; Department of Otorhinolaryngology and Plastic Head and Neck Surgery, University Medical Center, RWTH Aachen; Munich Cluster for Systems Neurology (SyNergy), Munich.
Abstract
BACKGROUND: Recent research findings have improved the understanding of the diagnosis, pathophysiology, genetics, etiology, and treatment of peripheral, central, and functional vestibular vertigo syndromes. METHOD: A literature search, with special attention to the current classification, treatment trials, Cochrane analyses, and other meta-analyses. RESULTS: There are internationally accepted diagnostic criteria for benign positional paroxysmal vertigo, Menière's disease, bilateral vestibulopathy, vestibular paroxysmia, and functional dizziness. Whether an acute vestibular syndrome is central or peripheral can usually be determined rapidly on the basis of the history and the clinical examination. "Cere - bellar vertigo" is a clinically important entity. For bilateral vestibulopathy, balance training is an effective treatment. For Menière's disease, preventive treatment with betahistine (48 mg and 144 mg per day) is not superior to placebo. For vestibular paroxysmia, oxcarbazepine has been shown to be effective. Treatments that are probably effective for functional dizziness include vestibular rehabilitation, cognitive behavioral therapy, and serotonin reuptake inhibitors. CONCLUSION: The diagnostic assessment of vestibular syndromes is much easier for clinicians now that it has been internationally standardized. There is still a lack of randomized, controlled trials on the treatment of, for example, Menière's disease, vestibular migraine, and "cerebellar vertigo."
BACKGROUND: Recent research findings have improved the understanding of the diagnosis, pathophysiology, genetics, etiology, and treatment of peripheral, central, and functional vestibular vertigo syndromes. METHOD: A literature search, with special attention to the current classification, treatment trials, Cochrane analyses, and other meta-analyses. RESULTS: There are internationally accepted diagnostic criteria for benign positional paroxysmal vertigo, Menière's disease, bilateral vestibulopathy, vestibular paroxysmia, and functional dizziness. Whether an acute vestibular syndrome is central or peripheral can usually be determined rapidly on the basis of the history and the clinical examination. "Cere - bellar vertigo" is a clinically important entity. For bilateral vestibulopathy, balance training is an effective treatment. For Menière's disease, preventive treatment with betahistine (48 mg and 144 mg per day) is not superior to placebo. For vestibular paroxysmia, oxcarbazepine has been shown to be effective. Treatments that are probably effective for functional dizziness include vestibular rehabilitation, cognitive behavioral therapy, and serotonin reuptake inhibitors. CONCLUSION: The diagnostic assessment of vestibular syndromes is much easier for clinicians now that it has been internationally standardized. There is still a lack of randomized, controlled trials on the treatment of, for example, Menière's disease, vestibular migraine, and "cerebellar vertigo."
Authors: L Frejo; E Martin-Sanz; R Teggi; G Trinidad; A Soto-Varela; S Santos-Perez; R Manrique; N Perez; I Aran; M S Almeida-Branco; A Batuecas-Caletrio; J Fraile; J M Espinosa-Sanchez; V Perez-Guillen; H Perez-Garrigues; M Oliva-Dominguez; O Aleman; J Benitez; P Perez; J A Lopez-Escamez Journal: Clin Otolaryngol Date: 2017-02-26 Impact factor: 2.597
Authors: Nadine Lehnen; Silvy Kellerer; Alexander G Knorr; Cornelia Schlick; Klaus Jahn; Erich Schneider; Maria Heuberger; Cecilia Ramaioli Journal: Front Neurol Date: 2018-07-17 Impact factor: 4.003
Authors: Marc Basil Schmid; David Bächinger; Athina Pangalu; Dominik Straumann; Julia Dlugaiczyk Journal: Front Neurol Date: 2022-07-01 Impact factor: 4.086
Authors: Astros Th Skuladottir; Gyda Bjornsdottir; Muhammad Sulaman Nawaz; Hannes Petersen; Solvi Rognvaldsson; Kristjan Helgi Swerford Moore; Pall I Olafsson; Sigurður H Magnusson; Anna Bjornsdottir; Olafur A Sveinsson; Gudrun R Sigurdardottir; Saedis Saevarsdottir; Erna V Ivarsdottir; Lilja Stefansdottir; Bjarni Gunnarsson; Joseph B Muhlestein; Kirk U Knowlton; David A Jones; Lincoln D Nadauld; Annette M Hartmann; Dan Rujescu; Michael Strupp; G Bragi Walters; Thorgeir E Thorgeirsson; Ingileif Jonsdottir; Hilma Holm; Gudmar Thorleifsson; Daniel F Gudbjartsson; Patrick Sulem; Hreinn Stefansson; Kari Stefansson Journal: Commun Biol Date: 2021-10-07
Authors: Cristina García-Muñoz; María Jesús Casuso-Holgado; Juan Carlos Hernández-Rodríguez; Elena Pinero-Pinto; Rocío Palomo-Carrión; María-Dolores Cortés-Vega Journal: BMJ Open Date: 2021-11-22 Impact factor: 2.692