Literature DB >> 32513802

Sequential Time-Kill, a Simple Experimental Trick To Discriminate between Pharmacokinetics/Pharmacodynamics Models with Distinct Heterogeneous Subpopulations versus Homogenous Population with Adaptive Resistance.

A Chauzy1, H Ih1,2, M Jacobs1, S Marchand1,3, N Grégoire1,3, W Couet4,3, J M Buyck1.   

Abstract

Experiments were conducted with polymyxin B and two Klebsiella pneumonia isogenic strains (the wild type, KP_WT, and its transconjugant carrying the mobile colistin resistance gene, KP_MCR-1) to demonstrate that conducting two consecutive time-kill experiments (sequential TK) represents a simple approach to discriminate between pharmacokinetics/pharmacodynamics models with two heterogeneous subpopulations or adaptive resistance.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Klebsiella pneumoniae; PK/PD model; antibiotic resistance; pharmacodynamics; polymyxin B; sequential time-kill

Mesh：

Substances：

Year:  2020        PMID： 32513802      PMCID： PMC7526804          DOI： 10.1128/AAC.00788-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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7.  Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.

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8.  Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model.

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  2 in total

Review 1.  Pharmacodynamic Parameters of Pharmacokinetic/Pharmacodynamic (PK/PD) Integration Models.

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2.  Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves.

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Journal:  Antimicrob Agents Chemother       Date:  2022-08-30       Impact factor: 5.938
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